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  • 1
    Digitale Medien
    Digitale Medien
    CD44 isoform expression in synovial sarcoma correlates with epitheliogenesis but not prognosis (2000)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 37 (2000), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Aims: We immunohistochemically determined the expression of CD44 standard and splice variant isoforms in a series of synovial sarcomas and sought correlations with histological subtype and clinical parameters including outcome. Methods  and results: From 39 patients, a total of 56 formalin-fixed and paraffin-embedded tumour samples (including initial, recurrent and metastatic tumours) were used to immunohistochemically evaluate the expression of epitopes encoded by CD44s and the CD44 splice variants CD44v3–v10. Significance of proposed prognostic indicators was evaluated in relation to the survival, time to local recurrence and time to metastases using log-rank analysis. Sixty-four percent of synovial sarcomas expressed CD44s and 46% expressed CD44v3–v10 (var). Synovial sarcomas with epithelial or epithelioid areas preferentially expressed CD44s in these areas when compared with the spindle cell element. There were no correlations with clinical parameters or outcome. Conclusions: The expression of CD44 was not found to correlate with survival, local recurrence or metastatic ability. In synovial sarcoma, CD44 and variant isoform expression appears to be associated with the degree of epithelial differentiation. CD44 expression in synovial sarcoma shows interesting similarities to CD44 expression in embryological epitheliogenesis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2559.2000.00953.x
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  • 2
    Digitale Medien
    Digitale Medien
    A novel immunohistochemical detection system using mirror image complementary antibodies (MICA) (1999)
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Histopathology 35 (1999), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: To describe and illustrate a novel and highly sensitive peroxidase-based immunohistochemical detection system which employs mutually attractive, mirror image complementary antibodies (MICA).〈section xml:id="abs1-2"〉〈title type="main"〉Methods and resultsTo demonstrate the sensitivity of the MICA system alongside the avidin–biotin complex (ABC) method, we selected a range of mouse monoclonal and rabbit polyclonal primary antibodies against antigens that are generally regarded as relatively difficult or impossible to detect on formalin-fixed, paraffin-embedded lymphoid tissue. Compared with the ABC method, the MICA immunodetection method enabled us to dilute primary antibodies up to 200-fold with equivalent or superior immunostaining results and, usually, considerably shortened primary antibody incubation times.〈section xml:id="abs1-3"〉〈title type="main"〉ConclusionsWe have described and illustrated a novel immunohistochemical detection system and demonstrated greatly increased sensitivity over the commonly used ABC system. An additional advantage of the MICA system is that it is avidin-free and so avoids non-specific staining due to endogenous tissue biotin.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2559.1999.00701.x
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  • 3
    Digitale Medien
    Digitale Medien
    Mucosal mast cells in reflux gastritis and chronic (type B) gastritis (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 15 (1989), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The histological features that characterize alkaline reflux gastritis are typical of the histamine-mediated response to tissue injury. We have investigated this in nine patients with symptomatic reflux gastritis following partial gastrectomy for duodenal ulcer by determining the gastric mucosal mast cell count before and after Roux-en-Y biliary diversion. Following diversion, the histological picture changed from that of reflux gastritis to type B chronic gastritis in all cases. The mean mucosal mast cell count in all patients was 47.57/mm2 before diversion and 123.33/mm2 after diversion (P 〉 0.05). Analysis of the paired data, in which eight out of nine patients showed a rise in mucosal mast cell numbers following bile diversion, also showed a significant difference before and after surgery (P 〈 0.01).The gastric mucosal mast cell count is significantly less in reflux gastritis than in type B chronic gastritis. This is most likely to be due to increased degranulation, which would explain why striking vascular changes occur in the absence of inflammatory cell infiltration in reflux gastritis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2559.1989.tb01613.x
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  • 4
    Digitale Medien
    Digitale Medien
    Sclerotome distribution of melorheostosis and multicentric fibromatosis (1998)
    Springer
    Skeletal radiology 27 (1998), S. 633-636 
    Details
    ISSN: 1432-2161
    Schlagwort(e): Key words Melorheostosis ; Multicentric fibromatosis ; C7 sclerotome
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  A case of melorheostosis affecting the C7 sclerotome is described, in association with synchronous multicentric fibromatosis. The foci of fibromatosis also affected the C7 sclerotome, suggesting a similar underlying pathogenesis for both diseases.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002560050449
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  • 5
    Digitale Medien
    Digitale Medien
    SAPHO syndrome: 20-year follow-up (1999)
    Springer
    Skeletal radiology 28 (1999), S. 159-162 
    Details
    ISSN: 1432-2161
    Schlagwort(e): Key words SAPHO syndrome ; CT ; Parosteal osteosarcoma ; Sternoclavicular joints
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Considerable attention has been paid in the past 10 years to the radiological spectrum of disease entities belonging to the SAPHO syndrome. We report an unusual case presenting with an extra-axial (femoral) lesion, prior to description of this syndrome, which was radiologically and histologically mistaken for a parosteal osteosarcoma. Nineteen years later, a further lesion developed in the scapula together with the typical sternoclavicular manifestations, at which stage the correct diagnosis of SAPHO syndrome was established.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002560050493
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  • 6
    Digitale Medien
    Digitale Medien
    Scintigraphically negative skip metastasis in osteosarcoma (1997)
    Springer
    European radiology 7 (1997), S. 1446-1448 
    Details
    ISSN: 1432-1084
    Schlagwort(e): Key words: Osteosarcoma ; Bone scintigraphy ; MRI ; Skip metastasis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. The accurate pre-operative evaluation of the intramedullary extent of osteosarcoma is essential, as it determines the level of bone resection. Radiographs, isotope bone and MR imaging scans have been considered as reliable in detecting skeletal metastasis and skip lesions. We report a case of osteosarcoma of the distal femur with a large skip lesion proximally which was not visualized by either routine radiography or bone scintigraphy, and was not included within the scan field on the initial MR imaging scan. The implications on patient management and possible reasons for failure of imaging to reveal the skip metastasis are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s003300050314
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  • 7
    Digitale Medien
    Digitale Medien
    Parosteal osteosarcoma of a metatarsal with intramedullary invasion (1999)
    Springer
    Skeletal radiology 28 (1999), S. 111-115 
    Details
    ISSN: 1432-2161
    Schlagwort(e): Key words Bone neoplasms ; Osteosarcoma ; Parosteal osteosarcoma ; Metatarsal ; MRI
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  A 70-year-old man presented with increasing swelling of 2 years’ duration, on the dorsal aspect of the forefoot. Imaging studies revealed a heavily calcified surface lesion of bone with early invasion of the underlying second metatarsal. Both imaging findings and the subsequent resection histology were consistent with a parosteal osteosarcoma, which is particularly rare at this site and at this age. The differential diagnosis of a mineralizing surface lesion of bone arising in the foot is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002560050485
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  • 8
    Digitale Medien
    Digitale Medien
    Fluid-fluid level in an intraosseous ganglion (1997)
    Springer
    Skeletal radiology 26 (1997), S. 667-670 
    Details
    ISSN: 1432-2161
    Schlagwort(e): Key words Intraosseous ganglia ; Juxta-articular bone cysts ; Fluid-fluid levels ; MRI
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  A case of an intraosseous ganglion with a fluid-fluid level visualised on MR imaging is presented. We discuss its possible pathogenesis and review other lesions that may exhibit this sign.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002560050308
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  • 9
    Digitale Medien
    Digitale Medien
    Ewing’s sarcoma presenting as a solitary bone cyst (1997)
    Springer
    Skeletal radiology 26 (1997), S. 722-724 
    Details
    ISSN: 1432-2161
    Schlagwort(e): Key words Ewing’s sarcoma ; Solitary bone cyst ; Malignancy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  This report describes a rare case of Ewing’s sarcoma presenting as a cystic lesion in the proximal humeral metaphysis. The clinical, pathological and radiological findings are described and discussed, with emphasis on the radiological appearances.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002560050318
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  • 10
    Digitale Medien
    Digitale Medien
    Synovial sarcoma arising in association with a popliteal cyst (2000)
    Springer
    Skeletal radiology 29 (2000), S. 713-716 
    Details
    ISSN: 1432-2161
    Schlagwort(e): Keywords Synovial sarcoma ; Popliteal cyst ; MR imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Synovial sarcoma is a relatively common soft tissue sarcoma particularly in the adolescent and young adult. We report an unusual case of a synovial sarcoma arising within a popliteal cyst in a 13-year-old female presenting with bilateral popliteal cysts. MR imaging demonstrated the cyst with evidence of subacute haemorrhage and a discrete nodule of tumour.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002560000281
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