ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
N-Nitroacetyl derivatives of L-proline, L-valine, and L-phenylalanine esters were prepared in two steps under mild conditions (Scheme 2). Regiospecific mono- and bis-allylation of these nitroacetyl derivatives were accomplished in presence of a Pd(0) catalyst. The bis-allyl derivatives 7-9 were obtained in 40-75% yield. The tertiary NO2 group in these compounds could be transformed into an acetylamino group by Zn/AcOH/Ac2O. The final products 11-13 are dipeptides in which the N-terminal glycine residue bears two α-allyl substituents.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19910740516
Permalink