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  • 1
    Electronic Resource
    Electronic Resource
    Influence of Candida albicans glycoprotein on 3-methylcholanthrene induced malignancy in newborn rodents (1971)
    Springer
    Mycopathologia 44 (1971), S. 95-100 
    Details
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In the experimental conditions reportedCandida albicans glycoprotein has a stimulating effect on the course of 3-methylcholanthrene carcinogenesis in newborn rodents. Stimulation of 3-methylcholanthrene carcinogenesis in newborn rats was found following injections of 9.5 µg/g and 18.5 µg/g ofCandida albicans glycoprotein. Subcutaneous tumors occurred in the experimental animals earlier, with higher frequency and attained larger dimensions than in the control animals. Similar effects were observed in mice. In the experimental mice there was also a significantly higher number of thymomas. From the evidence presentedCandida albicans glycoprotein appears to act as a cocarcinogenic substance to 3-methylcholanthrene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02051876
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  • 2
    Electronic Resource
    Electronic Resource
    Occurrence of malignancy, collagen diseases and myasthenia gravis in the course of experimental infections with Candida albicans (1963)
    Springer
    Mycopathologia 19 (1963), S. 1-20 
    Details
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02049009
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  • 3
    Electronic Resource
    Electronic Resource
    Blood changes and fertility derangements following the injection of Candida albicans into the spleen of the experimental animals (occurrence of hypersplenism) (1966)
    Springer
    Mycopathologia 30 (1966), S. 59-71 
    Details
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The injection ofCandida albicans (under experimental conditions used here) into the spleens of Wistar rats and Swiss mice produces profound hematological changes which are similar in rats and mice. After injection of the organisms there was steady lowering of the white cells and of the platelets in mice and in rats. Following splenectomy there was a sharp rise of both platelets and white cells in mice and rats. Mild normocytic, normochromic anemia was observed during the experiment. Following the splenectomy the level of hemoglobin returned to normal in fourteen weeks in the rats and in thirteen weeks in the mice. An increased level of reticulocytes and siderocytes was observed during the experiment. The mean value of the spleen weights in the experimental animals was higher than in the controls. Hyperplasia was the constant histological feature of these spleens. Bone marrow was either normal or hyperplastic. plastic. These changes correspond to the picture known in human pathology as hypersplenism. The injected organisms could still be cultured from the spleen about 4–6 months after operation. Attempts to isolate the injected organisms after 6 months were unsuccessful. The experimental mice showed derangement of fertility. Of the forty females mated with normal males only seven became pregnant. The litters were normal, 7–12 babies. Thirty percent of the young died before one month. Many of them showed growth retardation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02051710
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  • 4
    Electronic Resource
    Electronic Resource
    Increased carbohydrate content in the thymus and spleen in mice receiving Candida albicans orally (occurence of lymphomas) (1972)
    Springer
    Mycopathologia 47 (1972), S. 189-206 
    Details
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Following oral administration ofCancida albicans to non — inbred albino mice in the experimental conditions reported, an increased level of carbohydrate was found in the spleen and thymus. Significant increase of carbohydrate content in these organs was found to occur in the third month of the experiment and remained so, during the ten months of its duration with the exception of the fourth and fifth month. The carbohydrate content in other essential organs was in a similar range in the control and experimental animals. No significant differences in protein level in the control and experimental animals were found. This was regarded as an indication that the incresaed carbohydrate level in the thymus and spleen of experimental animals represents their reaction to the pathological influences of metabolic products ofCandida albicans. Appearance of lymphomas was observed between the seventh and tenth month. Three lymphomas were found in sixty four animals which were autopsied. Previously reported occurrence of lymphomas in mice which received injection ofCandida albicans to the spleen, provides circumstantial support that the observed increase of carbohydrate level as reported here in the spleen and thymus represents the pathological reaction towards metabolic products ofCandida albicans and forms the basis of a collapse of the defense system of the experimental animals. Thymus and spleen appear to act synergically in the reported experimental conditions and as a part of “enterodefense system”. The possibility of relevance of observed pathology to humans is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02051658
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  • 5
    Electronic Resource
    Electronic Resource
    The pathological activity of metabolic products of candida albicans on newborn mice (1962)
    Springer
    Mycopathologia 17 (1962), S. 165-175 
    Details
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Concentrated filtrates ofCandida albicans have an inhibiting effect on the growth of newborn mice. Occasionally, this inhibition of growth is very distinct and the clinical picture corresponds to human progeria. Increased dosages of subcutaneous injections of filtrates did not increase the frequency of appearance of distinctly retarded growth in mice, but the mice showed a great area of baldness. In the number of mice, which did not show progeria, there were degenerative changes in liver and kidneys morphologically suggesting glycogenosis. The same type of changes were also observed when contents of disruptedC. albicans cells were injected into newborn mice. In the later case there was positive histochemical staining for the deposits of glycogen. The induction of pathological changes through fungus filtrates is a newly described biological phenomenon, which may play a greater role in pathology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02076151
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  • 6
    Electronic Resource
    Electronic Resource
    The occurrence of liver portal cirrhosis and atrophy of the islet cells of the pancreas in the course of experimental candida albicans infection (1964)
    Springer
    Mycopathologia 22 (1964), S. 271-284 
    Details
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02049061
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  • 7
    Electronic Resource
    Electronic Resource
    Occurrence of lymphomas and lupus erythematosus-like syndrome in the course of experimental Candida albicans infection in mice (1972)
    Springer
    Mycopathologia 47 (1972), S. 167-182 
    Details
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Occurrence of four lymphomas was seen following injection of 1.4×103 Candida albicans cells to the spleen of eighty non - inbred albine mice. These neoplastic changes occurred in three to seven months of the duration of the experiment. Extensive invasion of the subcutaneous tissue by the tumor was found in one animal. Two of the animals with lymphoma also had changes in the kidneys compatible with lupus erythematosus and presence of LE cells in the blood. In other animals most frequent and extensive pathological changes were found in the kidneys and in order of frequency were as follows: thickening of the basement membrane, fibrinoid degeneration, presence of hematoxylin bodies, wireloop formation. In total, the presence of positive LE cells in blood was found in seven instances and suggestive LE cells was observed in eight animals. Finding of perisplenitis, exudative pleuritis and pericarditis gave additional support to the resemblance of observed pathological changes with human lupus erythematosus. The fact that occurrence of lymphomas and lupus erythematosus together has been reported in humans provides additional interest to the results reported. Results presented here and previously suggest that there may be more extensive interrelationship among variety of pathological changes observed than is accepted until now. Better understanding of host — parasite relationship ofCandida albicans, and possible other fungi, could advance out knowledge of pathogenesis of these diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02126164
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  • 8
    Electronic Resource
    Electronic Resource
    Occurrence of brain calcifications, iron deposits, and tonic-clonic convulsions following experimental infections with Candida albicans (1964)
    Springer
    Mycopathologia 23 (1964), S. 141-149 
    Details
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary During the prolonged presence ofCandida albicans in the spleen of Wistar rats, two cases of calcium deposits in the brain were observed. In one case there was one big calcium deposit at some distance from the cortex. In this case, thickening in a limited area of the leptomeninges was found. The animal had generalized tonicclonic convulsions which lead to death. In the second case, calcium deposits formed two separate agglomerations in the posterior part of the thalamus. Serial sections made at six micron intervals showed the presence of calcium deposits to a depth of forty-eight microns. At twenty-four microns other calcium deposits were observed in the thalamus symmetrically located to those described above. Small iron deposits were found in the anterior part of the thalamus and other iron deposits were found in the temporal lobe of the brain. They were arranged in a straight line along the capillary vessels and most of them were seen in the macrophages in the vicinity of the vessels. Since calcium deposits in the brain occurred in the same experimental conditions as reported cases of calcinosis, it is probable that the same mechanism is involved in all these pathological calcium deposits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02049271
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  • 9
    Electronic Resource
    Electronic Resource
    Seizure induction by pentylenetetrazol in animals experimentally infected with Candida albicans (1968)
    Springer
    Mycopathologia 34 (1968), S. 108-112 
    Details
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The prolonged presence ofCandida albicans in the spleen of experimental rats and mice predisposes them to pentylenetetrazol induced seizures. The seizure threshold of the experimental animals is lowered. This becomes statistically significant at ten months after the operation. In the experimental animals the latent period was sometimes reduced. The convulsions in experimental rats and mice were prolonged, sometimes repeated, and on three occasions (2 rats and 1 mouse) ended in death. Electroencephalographic studies confirmed the increased proneness to seizures in the animals to whichCandida albicans was introduced to the spleen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02051418
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  • 10
    Electronic Resource
    Electronic Resource
    Production of glycoprotein by Candida albicans in a synthetic medium and its influence on the growth of newborn mice (1968)
    Springer
    Mycopathologia 34 (1968), S. 113-118 
    Details
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Growth ofCandida albicans on a synthetic medium for a period of 6 weeks produces glycoprotein substance in the approximate amount of 150 mg per liter. The polysaccharide component is formed by glucose and mannose in the approximate ratio 3:1. The protein component is composed of at least 15 different amino acids. Half percent of glucosamine was also found. The glycoprotein substance is water soluble and toxic to Swiss mice. LD50 is 0.75 mg/g of body weight when injected intravenously. Subcutaneous injection to newborn Swiss mice produced inhibition of growth. The degree of inhibition varied with the dosage. On one occasion when using a small amount of compound, stimulation of growth was also seen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02051419
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