ISSN:
1573-4919
Keywords:
rat erythrocytes
;
menadione
;
dibutyryl-cyclic AMP
;
isobutylmethylxanthine
;
D-[2-3H]glucose metabolism
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract When rat erythrocytes are exposed to both dibutyryl-cyclic AMP and isobutylmethylxanthine, the rates of D-glucose phosphorylation and glycolysis are both markedly increased. On the contrary, menadione by increasing the flow rate through the pentose phosphate pathway, decreases the generation rate of triose phosphates from exogenous D-glucose. Yet, both procedures lead to a decrease in the production of3HOH from D-[2-3H]glucose relative to its phosphorylation rate. It is proposed, therefore, that such a radioactive measurement should no more be considered as a reliable index of D-glucose phosphorylation, at variance with current practice.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00928694
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