ISSN:
1365-3083
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
T-cell recognition requires direct cell-cell interactions mediated by major histocompatibility complex (MHC)-restricted α-β heterodimeric receptors (Ti) in association with a constant protein complex termed T3 (TcR, Ti-T3). Interleukin 2 (IL-2) promotes growth and maturation of T cells upon binding to high affinity receptors (IL2-R). They are expressed after the recognition of antigen on accessory cells through the TcR [44]. Furthermore, current hypotheses propose that T-cell interactions are also mediated by a group of T-cell antigens, particularly T4/L3T4 and T8/Lyt 2 [35], and perhaps Tγ [15]. All their encoding genes are rearranged and/or expressed sequentially during thymocyte differentiation [5, 8, 40, 41, 46, 51, 52]. Thus, developmental analyses of T-cell function are essential to gain insight into the mechanisms for selection of available repertoires, one of the central problems in immunology.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-3083.1986.tb02182.x
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