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  • 1
    Electronic Resource
    Electronic Resource
    Renal biopsy findings in long-term cyclosporin treatment of psoriasis (1997)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 136 (1997), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Renal biopsies were performed in 30 psoriatics during long-term low-dose cyclosporin (CsA) therapy (range 2·5–6 mg/kg per day) of from 6 months to 8 years. The study included pretreatment biopsies in 25 of the patients. After 2 years all biopsies shared features consistent with CsA nephropathy despite completely normal pretreatment morphology in 17 of the 25 patients. The severity of the findings which consisted of arteriolar hyalinosis, focal interstitial fibrosis and sclerotic glomeruli increased with length of therapy. Mild renal lesions were seen durhig the first 2 years. After 4 years all but one had arteriolar hyalinosis. with interstitial fibrosis pronounced in live and moderate in six of 11 patients. At the same time glomerular sclerosis had become significant. A decrease in glomerular filtration rate (GFR) correlated with severity of structural lesions. The data from our study together with experiences from cardiac-transplanted patients treated with CsA indicate that patients with psoriasis after 2 years therapy with CsA should be rotated to other treatments or be followed carefully by GFR and sequential renal biopsies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1997.6101586.x
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  • 2
    Electronic Resource
    Electronic Resource
    Adenomatoid tumour of the uterus (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 13 (1988), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Two adenomatoid tumours of the uterus were examined immunohistochemically using antibodies to keratin, Factor VIII related antigen, EMA, CEA and a specific protein isolated from mesothelioma cells. The tumour cells gave positive staining for keratin and for the specific mesothelial marker. The results strongly support a mesothelial origin for adenomatoid tumours and this panel of antibodies may be used to solve diagnostic problems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1988.tb02086.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A quantitative immunohistochemical study of the expression of mesangial α-smooth muscle actin and the proliferation marker Ki-67 in glomerulonephritis in man (1997)
    Springer
    Virchows Archiv 431 (1997), S. 345-350 
    Details
    ISSN: 1432-2307
    Keywords: Key words Mesangial actin ; Glomerulonephritis ; Proliferation marker Ki-67 ; Quantitative immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Using a specific marker 1A4 (DAKO), a quantitative evaluation of α-smooth muscle actin (ASMA) in glomeruli has been performed on human renal biopsies from patients suffering from acute, postinfectious, endocapillary glomerulonephritis (GN; 9 biopsies), IgA nephropathy (11 biopsies) and membranoproliferative GN (11 biopsies) and appropriate controls expressing a very weak ASMA reactivity. A significantly increased expression was found in all categories of GN. The glomeruli from IgA nephropathy showed variation of ASMA expression (range 0.1–27.7%) and a pattern of ASMA staining that was mesangial, global and diffuse. This pattern was also seen in cases of IgA nephropathy with focal, segmental, proliferative GN. In all biopsies, the glomerular cell number and proliferation index was determined. All the categories of GN showed significantly increased glomerular cellularity and proliferation index. Among the three types of GN, the glomerular cellularity and proliferation was lowest in IgA nephropathy. The mean number of Ki-67-positive intraglomerular nuclei and the proliferation index were both significantly correlated with the mean number of glomerular cell nuclei. Morphometric estimates demonstrate increased ASMA expression in types of GN with different prognosis. This finding and the lack of correlation with proliferation markers together indicate that the role of ASMA in GN is complex. This method of ASMA estimation may be useful in further studies of its role in disease activity and prognosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050109
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  • 4
    Electronic Resource
    Electronic Resource
    The distal nephron is preferentially infiltrated by inflammatory cells in acute interstitial nephritis (1992)
    Springer
    Virchows Archiv 420 (1992), S. 37-42 
    Details
    ISSN: 1432-2307
    Keywords: Acute interstitial nephritis ; Proximal tubules ; Distal nephron ; Tubular markers ; Tubulitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In acute interstitial nephritis (AIN), mononuclear cells invade the tubules (tubulitis). The segmental localization of tubulitis is not precisely known. To clarify this question, formalin-fixed kidney biopsy specimens from 13 patients with AIN were studied stereologically by identifying cortical tubules with segment-specific markers. The periodic acid-Schiff reaction, peanut lectin, and antibodies against Tamm-Horsfall protein and epidermal cytokeratins all applied to the same section were used to identify the proximal tubules (PTs), distal convoluted tubules, distal straight tubules, and the cortical collecting system (connecting tubules and cortical collecting ducts), respectively. Morphometrically, an estimate of the relative volume of the inflammatory cell infiltrates within each category of tubular segments was obtained. Inflammatory cells were infrequently found in PTs (1.2%) but were frequently localized in distal tubules and the cortical collecting system (7.6%). There was no difference in the amount of the inflammatory cell infiltrate within these segments. Re-examination of an electron microscopic study of AIN carried out in this laboratory revealed that mononuclear cells were rarely seen in convoluted PTs but were frequently observed in straight PTs and all segments distal to them. The observations indicate that it is the distal nephron which is primarily affected by inflammatory cell infiltration in AIN.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01605982
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    Paper (German National Licenses)
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