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  • 1
    Electronic Resource
    Electronic Resource
    Simultaneous occurrence of Hodgkin’s disease, nodal Langerhans’ cell histiocytosis and multiple myeloma IgA(κ) (1999)
    Springer
    Virchows Archiv 434 (1999), S. 259-262 
    Details
    ISSN: 1432-2307
    Keywords: Key words Hodgkin’s disease ; Myeloma ; Langerhans’ cell histiocytosis ; Discordant lymphoma ; Lymph node
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A 35-year-old man suffered simultaneously from nodular sclerosis Hodgkin’s disease (HD), Langerhans’ cell histiocytosis and multiple myeloma (MM). There was no prior history of irradiation or chemotherapy, and clinically the lymphoma was confined to cervical lymph nodes. Immunohistochemically, neoplastic lymphoma cells reacted with CD15 and CD30 markers. The patient’s bone marrow exhibited a diffuse infiltration by rather atypical plasma cells showing κ immunoglobulin light-chain restriction. At 14 months after the diagnosis, after autologous bone marrow transplantation, the clinical evolution is favourable with complete remission of the diseases. This is the first time that the coexistence of these three haematological disorders has been discussed, and only the fourth documented case of simultaneous HD and MM. Speculations about the significance of this finding are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050338
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Granular cell basal cell carcinoma. Light microscopy, immunohistochemical and ultrastructural study (1993)
    Springer
    Virchows Archiv 422 (1993), S. 173-177 
    Details
    ISSN: 1432-2307
    Keywords: Basal cell carcinoma ; Skin tumours ; Granular cell tumours ; Granular cell basal cell carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Granular cell basal cell carcinoma (BCC) is a rare histological variant of BCC. In this, the fifth reported case, a 67-year-old male with BCC located on the nose, light microscopy examination showed a tumour with the classical configuration of nodular BCC, in which most cells had finely granular eosinophilic cytoplasm. Ultrastructural observation showed numerous lysosome-like granules filling the cytoplasm of tumour cells, along with numerous well-formed pentalaminate desmosomes. Immunohistochemical profile (including positivity for keratins C 5.2 and AE 1 and for Leu-M1), together with the presence of cytoplasmic tonofilament bundles and desmosomes, are consistent with the proposed epithelial origin of granular cells in this tumour.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01607170
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Gastrointestinal autonomic nerve tumours and their separation from other gastrointestinal stromal tumours: an ultrastructural and immunohistochemical study of seven cases (1995)
    Springer
    Virchows Archiv 426 (1995), S. 27-35 
    Details
    ISSN: 1432-2307
    Keywords: Gastrointestinal autonomic nerve tumours ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Gastrointestinal stromal tumours (GIST) represent a heterogeneous group whose classification frequently requires ultrastructural and immunohistochemical studies. In a retrospective study of the ultrastructural findings of 24 gastrointestinal stromal tumours, whose light microscopic study has yielded ambiguous results and in which accurate diagnosis had required ultrastructural support, seven were found to have the characteristics of gastrointestinal autonomic nerve (GAN) tumours. In all of them the diagnosis was based on the presence of dendritic processes with dense neuroendocrine granules. Immunohistochemically, the seven tumours were negative for smooth-muscle markers. All stained positively for vimentin. NSE, chromogranin, and synaptophysin were positive in most of them, while S-100 protein was positive only in two cases. We present the ultrastructural and immunohistochemical features of seven GANT against the background of the GISTs of our series. We conclude that GAN tumours cannot be diagnosed by light microscopy alone but this tumour group displays characteristic electron microscopic and immunohistochemical features and appears to represent a distinct type of GIST.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00194695
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Human triploid embryo (1977)
    Springer
    Human genetics 〈Berlin〉 39 (1977), S. 251-256 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A cytogenetic and anatomopathologic study of an embryo of 24 mm crown-rump length showing pure triploidy (69,XXY) is reported. Anomalies such as unilateral genitourinary agenesia, aortic alterations, defects in cerebral development, and anomalies of the chorionic villi were detected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00287021
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    Paper (German National Licenses)
    Fulltext
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