ISSN:
0025-116X
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Physics
Notes:
Chlorides of carboxylic acids were grafted on telomers of vinyl alcohol. The yields of grafting were improved by increasing the temperature and the concentration of the reactants. In the range investigated, they do not depend on the DPn of the telomers, nor on the stoichiometric rates of the reactants. Therefore, the grafting rates are directly related to the initial conditions of the reaction. Modification of the telomers by treatment with ethylene oxide provides more soluble substances, but it does not affect the behaviour of the telomers in grafting reactions. Grafting of 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolacetic acid (9) (indomethacin), an antiinflammatory drug, leads to potentially pharmacologically active telomers.
Additional Material:
12 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/macp.1981.021821204
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