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  • 1
    Electronic Resource
    Electronic Resource
    Many an error by the same example
    Amsterdam : Elsevier
    Trends in Biochemical Sciences 19 (1994), S. 359 
    Details
    ISSN: 0968-0004
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0968-0004(94)90110-4
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of insulinomimetic agents on protein degradation in H35 hepatoma cells (1986)
    Springer
    Molecular and cellular biochemistry 71 (1986), S. 159-166 
    Details
    ISSN: 1573-4919
    Keywords: protein degradation ; insulin ; insulin mechanism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract A wide variety of agents are shown to mimic insulin action and inhibit rates of intracellular protein degradation in H35 hepatoma cells. For oxidizing agents such as NaNO2, H2O2 and oxidized glutathione, inhibition of protein breakdown is reversed by adding catalase. Phenylhydrazine behaves like an oxidant and mimics insulin action in a manner potentiated by superoxide dismutase and reversed by catalase. Similarly the effect of insulin itself is increased by superoxide dismutase and reduced by catalase. Sulfhydryl reagents also mimic insulin action: inhibition of protein breakdown is seen following addition of 2-mercaptoethanol or a brief pre-treatment with N-ethylmaleimide or iodoacetate. Mild pre-treatment with trypsin also inhibits subsequent rates of protein breakdown. A model is proposed suggesting that these insulinomimetic actions involve a common mechanism which links the generation of active oxygen species through the redox potential of the cell to the activation of a proteinase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00214775
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Enhancement of phenotypic expression in cultured malignant liver epithelial cells by a complex medium (1976)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 87 (1976), S. 79-87 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The ability of two media identically supplemented with serum to maintain functional and structural differentiated properties of cultured malignant liver epithelial cells was compared. Reuber H35 hepatoma cells grown in a complex medium, Medium E, possessed the gluconeogenic enzyme phosphoenolpyruvate carboxykinase and bile canaliculi. When grown in Eagle's Minimal Essential Medium, the activity of phosphoenolpyruvate carboxykinase was reduced and bile canaliculi were not formed. This decrease in properties was restored when cells maintained in Minimal Essential Medium were returned to Medium E. It was concluded that the enhanced phenotypic expression was probably due to enrichment of the nutrient environment.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040870111
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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