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Comparative bioavailability and pharmacokinetics of noscapine hydrogen embonate and noscapine hydrochloride (1986)

Haikala, V. ; Sothmann, A. ; Marvola, M.

Springer

European journal of clinical pharmacology 31 (1986), S. 367-369

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ISSN: 1432-1041

Keywords: noscapine hydrochloride ; noscapine hydrogen embonate ; pharmacokinetics ; bioavailability

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The relative bioavailability and pharmacokinetics of two orally administered aqueous suspensions of noscapine hydrogen embonate were compared with those of noscapine hydrochloride solution. Noscapine hydrochloride showed faster absorption and gave a higher peak concentration than the embonate. The average bioavailability of the embonates was 71% of that of the noscapine solution (p〈0.05). No significant difference was observed when the embonate was administered with water, polyvidone and flavouring agents.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00981140

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