Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Clinical and experimental pharmacology and physiology
12 (1985), S. 0
ISSN:
1440-1681
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
1. In rat isolated perfused tail arteries, dose-response curves were established for the vasopressor effects of phenylephrine (α1-adrenoceptor agonist), clonidine (α1- and α2-adrenoceptor agonist), clonidine in the presence of 10-7 mol/l prazosin (α2-agonist), and BHT-920 (α2-agonist).2. The ED50 values were: phenylephrine 1.85 × 10-10 mol; clonidine 6.3 × 10-10 mol; clonidine + prazosin 3.2 × 10-6 mol; BHT-920 6.1 × 10-6 mol.3. The arterial reactivity to BHT-920 was stable only after 4–5 h of perfusion.4. Responses to BHT-920 were not antagonized by yohimbine (α2-adrenoceptor antagonist) but were antagonized by low concentrations of prazosin (α1-adrenoceptor antagonist).5. These data constitute conflicting evidence regarding the existence of α2-adrenoceptors in rat tail arteries.6. The data are consistent with the proposal that there are two recognition sites on α1-adrenoceptors; phenylephrine and BHT-920 may stimulate different sites on α1-adrenoceptors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1440-1681.1985.tb02637.x
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