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  • 1
    Electronic Resource
    Electronic Resource
    Iron and inflammatory bowel disease (2001)
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 15 (2001), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Both anaemia of iron deficiency and anaemia of chronic disease are frequently encountered in inflammatory bowel disease. Anaemia of iron deficiency is mostly due to inadequate intake or loss of iron. Anaemia of chronic disease probably results from decreased erythropoiesis, secondary to increased levels of proinflammatory cytokines, reactive oxygen metabolites and nitric oxide.Assessment of the iron status in a condition associated with inflammation, such as inflammatory bowel disease, is difficult. The combination of serum transferrin receptor with ferritin concentrations, however, allows a reliable assessment of the iron deficit.The best treatment for anaemia of chronic disease is the cure of the underlying disease. Erythropoietin reportedly may increase haemoglobin levels in some of these patients. The anaemia of iron deficiency is usually treated with oral iron supplements. Iron supplementation may lead to an increased inflammatory activity through the generation of reactive oxygen species. To date, data from studies in animal models of inflammatory bowel disease support the theoretical disadvantage of iron supplementation in this respect. The results, however, cannot easily be extrapolated to the human situation, because the amount of supplemented iron in these experiments was much higher than the dose used in patients with iron deficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2001.00930.x
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of Nontransferrin-bound Iron on the Aggregation and Adhesion of Polymorphonuclear Granulocytes (PMN) (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 526 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb55529.x
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  • 3
    Electronic Resource
    Electronic Resource
    Localization of Iron in the Hepatic Acini and in Bile Duct Epithelium as a Tool for Estimation of Liver Iron Overload (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 526 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb55528.x
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  • 4
    Electronic Resource
    Electronic Resource
    Evaluation of the Role of Fcγ and Complement Receptors in the Decreased Phagocytosis of Hereditary Haemochromatosis Patients (1997)
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 46 (1997), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Hereditary haemochromatosis (HH) monocytes have a decreased antibody mediated phagocytosis of rabbit erythrocytes and Staphylococcus aureus compared to control monocytes. In order to investigate whether this decrease could be attributed to a different level of expression of Fcγ receptors (FcγR) or complement receptors (CR), which cooperate even in the absence of complement, the surface expression of these receptors was determined on monocyte-enriched suspensions. In contrast to what was expected, HH monocytes displayed a significantly higher level of FcγRI and FcγRIIa as compared to healthy donor monocytes, but these differences were very small. The expression of the other receptors studied were similar for both groups. The heat-inactivated mouse serum used for opsonizing the erythrocytes mainly contained mouse IgG1. Two genetically different forms of FcγRIIa are known, each with a different affinity for mouse IgG1 antibodies. Therefore, the FcγRIIa polymorphism in monocytes (MN) of both groups was also investigated. A similar distribution was found for patients and healthy donors. In addition, the extent of erythrophagocytosis of both donors and patients was independent of FcγRIIa allotype. Our results indicate that the altered phagocytosis by HH monocytes cannot be attributed to a different level of expression of receptors involved in phagocytosis or to FcγRIIa polymorphism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.1997.d01-137.x
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  • 5
    Electronic Resource
    Electronic Resource
    Phase I study using desferrioxamine and iron sorbitol citrate in an attempt to modulate the iron status of tumor cells to enhance doxorubicin activity (1993)
    Springer
    Cancer chemotherapy and pharmacology 31 (1993), S. 357-362 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary a novel approach to enhance the activity of doxorubicin is to increase the availability of cellular “chelatable” iron to participate in doxorubicin-mediated free-radical generation. To achieve this, we designed a regimen consisting of desferrioxamine (DFO, 50 mg/kg daily given as an i. v. infusion over 72 h) to increase cellular iron uptake. Thereafter, the combination of iron sorbitol citrate (ISC) and doxorubicin (as a single agent or as part of the CHOP regimen) was given. In a phase I study we investigated the toxicity of this regimen in nine patients with refractory malignant disease. Severe but reversible ocular toxicity (i. e., acute maculopathy) was observed in two patients. As these patients were the only ones who were pretreated with cisplatin, we caution against the use of DFO in cisplatin-pretreated patients. Severe phlebitis was encountered in five of nine patients. A partial remission was observed in two of four patients with refractory Non-Hodgkin's lymphoma who were treated with DFO, ISC, and doxorubicin as part of the CHOP regimen. We conclude that pretreatment with DFO and iron sorbitol citrate may be of benefit in the treatment of malignancies with doxorubicin-containing regimens, but ocular toxicity and severe phlebitis limits the use of DFO in this approach. The attachment of DFO to biocompatible polymers may be a method of overcoming the observed toxicity and warrants further study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686148
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  • 6
    Electronic Resource
    Electronic Resource
    Muscosal uptake, mucosal transfer and retention of a therapeutic dose of iron (1982)
    Springer
    European journal of clinical pharmacology 23 (1982), S. 335-338 
    Details
    ISSN: 1432-1041
    Keywords: ferrous ascorbate ; iron absorption ; iron deficiency ; mucosal transfer ; mucosal uptake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The absorption of a pharmacological dose of iron was assessed by determination of mucosal uptake, mucosal transfer and retention of 33 mg Fe(II) as ferrous sulphate and ferrous ascorbate. 20 subjects were studied in a cross-over trial, 11 with normal iron stores and 9 with iron deficiency according to the serum ferritin concentration. The activity of59Fe and51Cr (administered as a non-absorbable indicator) was measured by whole-body counting. There was no difference in absorption between the two iron compounds in normal subjects. Absorption of ferrous ascorbate averaged 52% higher than ferrous sulphate in subjects with iron deficiency. The difference was the result of higher mucosal uptake, probably because oxidation of Fe(II) in the alkaline milieu of the intestine, which leads to formation of non-absorbable Fe(III) complexes, was prevented. The mucosal transfer fraction of both compounds was identical.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00613616
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  • 7
    Electronic Resource
    Electronic Resource
    Defects of phagocytic cells in patients with iron overload (1982)
    Springer
    Antonie van Leeuwenhoek 48 (1982), S. 192-194 
    Details
    ISSN: 1572-9699
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00405205
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  • 8
    Electronic Resource
    Electronic Resource
    Inhibition of bacterial multiplication by the iron chelator deferoxamine: Potentiating effect of ascorbic acid (1983)
    Springer
    European journal of clinical microbiology & infectious diseases 2 (1983), S. 426-431 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Since iron is essential for the multiplication of microorganisms, the effect of the iron chelator deferoxamine, with or without ascorbic acid, on the growth of 43 strains ofStaphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Alcaligenes faecalis, Neisseria meningitidis and species ofSalmonella, Enterobacter, Pseudomonas andProvidencia, was investigated with the use of an automated turbidimeter. Addition of deferoxamine (25–400Μg/ml) to the incubation medium was inhibitory in a dose-dependent fashion. At concentrations between 200–400 Μg/ml, growth was about 25 % lower than control values. However, when ascorbic acid (100Μg/ml) was added to the culture medium, this antimicrobial activity of deferoxamine was significantly increased to on average 75 % of the control value (p〈0.05). Ascorbic acid alone had no bacteriostatic properties. Growth in the presence of 200Μg/ml deferoxamine combined with 100Μg/ml ascorbic acid was significantly lower than that in control media without additions (p〈0.001). Addition of ferric citrate to the culture medium at a concentration sufficient to saturate all of the deferoxamine with iron, abolished the growth inhibiting effect of deferoxamine. The results provide evidence that deferoxamine is bacteriostatic due to its capacity to deplete iron which would otherwise be used for bacterial multiplication, and that ascorbic acid enhances this antibacterial property of deferoxamine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02013899
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  • 9
    Electronic Resource
    Electronic Resource
    Mucosal uptake, mucosal transfer and retention of iron in veal calves (1993)
    Springer
    Veterinary research communications 17 (1993), S. 209-217 
    Details
    ISSN: 1573-7446
    Keywords: calves ; haematology ; iron absorption ; iron deficiency ; iron retention ; radio-tracer ; veal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A method for studying iron absorption in humans was adapted to veal calves. Three 10-week-old calves with moderate (calves 1 and 2) or severe (calf 3) iron deficiency were given an abomasal injection of59Fe and51Cr and all their faeces were collected over 15 days in order to measure mucosal uptake, mucosal transfer and retention of iron. The mucosal uptake was 62.2, 53.4 and 71.8% in calves 1, 2 and 3, respectively. The iron retention measured 14 days after administration of the test dose was 57.4, 52.3 and 56.4% in calves 1, 2 and 3, respectively. Maximal plasma activity was found in all three calves between 1 1/2 and 2 h after injection of the test dose. The plasma activity decreased rapidly, with a slight increase between the 5th and the 10th hour. After 21 h, less than 0.25% of the injected dose was still present in 1 litre of plasma. Not all the51Cr was recovered in the faeces. No59Fe was found in the urine but some51Cr could be detected. The results of this study show that the method described is useful for measuring the different steps of iron absorption in iron-deficient veal calves.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01839169
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