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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European radiology 2 (1992), S. 148-153 
    ISSN: 1432-1084
    Keywords: Brainstem, MR studies ; Brainstem, abnormalities ; Nervous system, MR studies ; Nervous system, abnormalities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract One thousand consecutive cranial MR exams were scrutinized for the neurovascular relationships of the vertebrobasilar arteries to the brainstem. Patients with indentations of the brainstem adjacent to vessels were evaluated for deficits of cranial nerves and long tracts by clinical and electrophysiological investigations unless an underlying neurologic disorder was present. The total incidence of neurovascular grooves was 8.3% with increasing frequency from the upper pons to the lower medulla and a higher rate in the older age and in males. Three different types of cross-sectional morphology could be identified. Two out of three were left-sided and mainly due to anterolateral contact of the left vertebral artery. No correlation between (sub)clinical neurological deficiencies and the grooves could be found, irrespective of their grade. Vascular grooves at the brainstem adjacent to the vertebrobasilar arteries are not too rare a finding, especially in the elderly, but even large indentations are unlikely to cause neurological deficits alone.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 152 (1993), S. 271-271 
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1076
    Keywords: Complex I deficiency ; Polyvitamin therapy ; Dichloroacetate therapy ; Polyneuropathy ; Thiamine administration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A therapeutic trial with polyvitamins and dichloroacetate (DCA) in combination with thiamine in a 13-year-old girl with complex I deficiency is reported. The polyvitamin therapy included thiamine, riboflavin, ascorbate, coenzyme Q 10 and carnitine. This therapeutic regine was used over a period of 17 months without any effect. Although DCA lowered the lactate concentration in blood and CNS — measured by magnetic resonance spectroscopy — no clinical benefit was achieved. After 20 weeks of DCA therapy a distal polyneuropathy with areflexia developed although 100 mg thiamine daily as comedication was given from the beginning of DCA therapy. Nerve conduction velocity of the peroneal nerve was not detectable, sensible evoked potentials of the tibialis posterious nerve were normal. This side-effect resolved completely within 6 months after omission of DCA. Our observation suggests a direct toxic effect of DCA only on the peripheral nervous system in our patient since several cerebral MRI and magnetic resonance spectroscopy studies showed no abnormalities. Conclusion DCA lowers the lactate concentration in children with complex I deficiency of the respiratory chain in a dose of 100 mg/kg body weight without clinical benefit. Reversible peripheral polyneuropathy may develop under DCA therapy despite thiamine medication.
    Type of Medium: Electronic Resource
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