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  • 1
    Electronic Resource
    Electronic Resource
    Development and reacquisition of tolerance to ethanol administered pre- and post-trial to rats (1981)
    Springer
    Psychopharmacology 73 (1981), S. 165-167 
    Details
    ISSN: 1432-2072
    Keywords: Ethanol ; Tolerance ; Loss of tolerance ; Reacquisition of tolerance ; Behaviorally augmented tolerance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The development of tolerance to the disruptive effects of ethanol on bar-pressing behavior was studied in rats by exposing them to four cycles of drug administration intercalated by 34-day drug-free periods. A negative correlation was obtained between the successive cycles and the number of sessions required for the rats to reach the criterion of tolerance. Also studied was the possible difference in the rate of development of tolerance in the four cycles when ethanol was administered before or after the task. One group of rats was required to perform the response under the influence of ethanol, while other group received the drug 90 min after the bar-pressing sessions. At the first cycle the group which performed under drug action developed tolerance more rapidly than the group which received ethanol after the task.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429210
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Genetic selection of winner and loser rats in a competitive situation (1974)
    [s.l.] : Nature Publishing Group
    Nature 249 (1974), S. 284-284 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The apparatus is described in detail elsewhere5. Briefly, it consisted of a straight wood runway 100 cm long, connected at the extremities with two identical open-topped chambers; a guillotine door bisected the runway. The animals had food withheld for 20-22 h and were trained individually every 48 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/249284a0
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  • 3
    Electronic Resource
    Electronic Resource
    Response variability of ethanol-induced locomotor activation in mice (1988)
    Springer
    Psychopharmacology 96 (1988), S. 547-550 
    Details
    ISSN: 1432-2072
    Keywords: Ethanol stimulation ; Activity ; Chronic ethanol ; Amphetamine and ethanol ; Ethanol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mice from a randomly bred strain were divided into two groups according to their locomotor responses to ethanol (0.8–3.0 g/kg): in two thirds of the tested animals ethanol increased locomotor activity (ethanol activated — EA), whereas in the remaining one third it did not (ethanol non-activated — ENA). Both groups did not differ in their locomotor activity after saline administration. Furthermore, EA and ENA mice presented a similar increase in locomotor activity after challenge with 1.0 and 2.0 mg/kgd-amphetamine. Chronic exposure to ethanol increased the ethanol-induced locomotor activation in both EA and ENA groups. The possibility that the lack of responsiveness of ENA mice to ethanol's acute activating effect could be due to a higher sensitivity to the depressant effect of ethanol is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02180038
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  • 4
    Electronic Resource
    Electronic Resource
    The behavior of worker and non-worker rats under the influence of (−) δ9-trans-tetrahydrocannabinol, chlorpromazine and amylobarbitone (1972)
    Springer
    Psychopharmacology 25 (1972), S. 57-68 
    Details
    ISSN: 1432-2072
    Keywords: Cannabis ; Chlorpromazine ; Amylobarbitone ; Rats' Social Behavior
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of Δ 9-THC, chlorpromazine and amylobarbitone on the labor division achieved by rats were studied. While the first two drugs in the doses of, respectively, 5.0 and 3.0 mg/kg, induced an inversion in the social pattern, amylobarbitone was ineffective at doses of 10.0 and 20.0 mg/kg; labor division of rats trained under a CRF was more sensitive to the drugs effects than that of animals under a VI schedule of reinforcement. Results were discussed in terms of a drug induced deconditioning effect without loss of motivation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422617
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  • 5
    Electronic Resource
    Electronic Resource
    Influence of (−) Δ9-trans-tetrahydrocannabinol and mescaline on the behavior of rats submitted to food competition situations (1971)
    Springer
    Psychopharmacology 22 (1971), S. 187-194 
    Details
    ISSN: 1432-2072
    Keywords: Δ 9-THC ; Marihuana ; Mescaline ; Hallucinogenic Drugs ; Competitive Behavior
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of laggy-tetrahydrocannabinol (Lagman-THC) on rat interaction were studied using two different food competition situations. With one of the methods the drug increased “winning” behavior while with the other an opposite result was obtained. Mescaline increased “winning” behavior although it has been previously reported as able to inhibit “dominance” in rats. These data suggest that methodology is an important variable when the effects of drugs on rat interaction is being studied. The results obtained with Δ 9-THC are tentatively explained in terms of a drug-induced distortion in perception.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403627
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of acute and chronic administration of cannabis sativa and (−)Δ9-trans-tetrahydrocannabinol on the behavior of rats in an open-field arena (1971)
    Springer
    Psychopharmacology 19 (1971), S. 388-397 
    Details
    ISSN: 1432-2072
    Keywords: Marihuana ; Δ 9-Tetrahydrocannabinol ; Emotional Behavior ; Habituation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of acute and chronic administration of Δ 9-THC, cannabis extract and control solution on the behavior of rats repeatedly exposed to an open-field arena have been studied. After the first dose both Δ 9-THC and cannabis extract significantly decreased defecation, grooming and rearing; ambulation was not affected. After 20 injections of both marihuana compounds the rats showed values for defecation, grooming and rearing near to those obtained during the predrug phase; control rats, however, showed a significant decrease in these parameters indicating habituation to the open-field. The results are discussed in terms of effects of marihuana on emotional behavior of rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404383
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  • 7
    Electronic Resource
    Electronic Resource
    Failure of chlorpromazine to protect rats against the effects of shock administration during the second month of life (1973)
    Springer
    Psychopharmacology 28 (1973), S. 301-307 
    Details
    ISSN: 1432-2072
    Keywords: Chlorpromazine ; Shock ; Infancy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The administration of shock during 45–55 days after birth had a long lasting influence on the behavior of adult rats, as measured by three different tests. Shocked rats behaved more fearfully even 4 months after the infantile treatment. Chlorpromazine had no protective effect; on the contrary, it had by itself a deleterious influence on later behavior. These data suggest that the second month of life is a susceptible period, for inducing behavioral changes in adult life not only through aversive stimuli but also by the administration of pharmacological agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429310
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