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  • 1
    Electronic Resource
    Electronic Resource
    Effects of trypanosome inferction and postpartum liveweight change on resumption of reproduction activity in N'Dama cows
    Amsterdam : Elsevier
    Theriogenology 39 (1993), S. 985-995 
    Details
    ISSN: 0093-691X
    Keywords: N'Dama cattle ; calving interval ; trypanosome ; weight change
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0093-691X(93)90435-8
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  • 2
    Electronic Resource
    Electronic Resource
    Preoperative operant circling training facilitates recovery following unilateral substantia nigra lesion in rats
    Amsterdam : Elsevier
    Behavioral and Neural Biology 58 (1992), S. 37-44 
    Details
    ISSN: 0163-1047
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Psychology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0163-1047(92)90877-7
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  • 3
    Electronic Resource
    Electronic Resource
    The role of chlorpheniramine in inhibitory avoidance in Danio vevio (2002)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 60 (2002), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The action of chlorpheniramine in learning and memory in Danio rerio suggested that 1 mg kg−1 produced an amnesiac effect in inhibitory avoidance in this species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.2002.tb01728.x
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  • 4
    Electronic Resource
    Electronic Resource
    A phase II study of Tomudex alternated with methotrexate, 5-fluorouracil, leucovorin in first-line chemotherapy of metastatic colorectal cancer (1999)
    Springer
    Annals of oncology 10 (1999), S. 985-987 
    Details
    ISSN: 1569-8041
    Keywords: alternating regimens ; colorectal cancer ; methotrexate/5-fluorouracil combination ; Tomudex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: This multicenter phase II study was designed to assess the efficacy of the alternating schedule of tomudex with methotrexate (MTX)/5-fluorouracil (5-FU)/leucovorin (LV) in first-line chemotherapy for metastatic colorectal cancer. Patients and methods: Patients with histologically proven metastatic colorectal cancer and at least one bidimensionally measurable lesion, aged 18–70, with performance status ≤2, normal baseline biological values, and no prior chemotherapy, were selected. Treatment was tomudex 3 mg/m2 and, after two weeks, MTX, 200 mg/m2 by 30′ infusion after hydration with 1500 ml saline solution, followed on day 2 by 5-FU, 600 mg/m2 and leucovorin, orally, 15 mg for six times every 6 hours, beginning 24 hours after MTX. Cycles were repeated every four weeks. Tumor response assessment was performed after three cycles. Results: Thirty-four patients were enrolled in this study, of whom twenty-four had liver metastases, nine local relapse, five lymph node involvement, four lung metastases, and three peritoneal carcinomatosis. Four patients achieved objective responses (one complete and three partial), for an overall response rate of 12% (95% CI: 0%–22%). Twelve patients had stable disease and 18 progressed on therapy. Median survival for all patients was 13 months. Two patients experienced grade 3 WHO neutropenia while hepatotoxicity was reported in 13 patients (6 grade 1, 3 grade 2, 3 grade 3, 1 grade 4), suggesting that this combination could increase hepatic toxicity in comparison to tomudex or MTX/5-FU alone. Conclusions: Our results suggest that this regimen does not warrant further investigation in advanced colorectal cancer patients, at least not with this schedule and doses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008373817826
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  • 5
    Electronic Resource
    Electronic Resource
    African horse sickness and equine infectious anaemia serology in The Gambia (1992)
    Springer
    Tropical animal health and production 24 (1992), S. 207-208 
    Details
    ISSN: 1573-7438
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02356746
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  • 6
    Electronic Resource
    Electronic Resource
    Susceptibility to different tick genera in Gambian N'Dama and Gobra zebu cattle exposed to naturally occurring tick infestations (1995)
    Springer
    Tropical animal health and production 27 (1995), S. 95-105 
    Details
    ISSN: 1573-7438
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les tiques ont été collectées chaque semaine pendant un an sur un côté du corps, et sur la totalité de la queue, sur 11 bovins Ndama (Bos taurus) et sur 11 zébus Gobra (Bos indicus) afin de déterminer la sensibilité inhérente à la race dans les conditions d'infestation naturelles. Un test ELISA a également été réalisé pour rechercher la prévalence sérologique de l'antigène d'Anaplasma marginale et de l'anticorps deBabesia bigemina. L'hématocrite (PRC) a été mesuré et le gain des poids enregistré. Les comptages d'Amblyomma variegatum et deHyalomma spp ont été significativement plus élevés sur les Gobra que sur les Ndama avec respectivement p 〈 0,002 et p 〉 0,001. La prévalence sérologique de l'antigène d'Amblyomma marginale était significativement plus faible pour la race Ndama, alors qu'aucune différence n'a été trouvée dans celle des anticorps deB. bigemina entre les deux races. L'hématocrite a été négativement affecté par l'infection àA. marginale dans les deux races, mais à un moindre degré chez les Ndama. Le gain de poids était significativement plus élevé (pour p 〈 0,003) chez les Ndama, comparé à celui du bétail Gobra pendant la péroide oùA. variegatum etHyalomma spp se rencontraient en abondance à l'état adulte. La charge significativement plus basse d'A. variegatum et deHyalomma spp sur le bétail Ndama gambien comparée à celle du bétail Gobra confirme les précédentes découvertes. Elle révèle également que le rôle des tiques et des maladies transmises par les tiques sur la production et la santé animale est plus pernicieux chez le Gobra que chez le Ndama. La présence d'un facteur “résistance aux tiques” chez le bétail Ndama est suggérée.
    Abstract: Resumen A lo largo de un año, se recolectaron garrapatas de la mitad del cuerpo y del total de la cola, una vez a la semana, en 11 animales N'dama (Bos taurus) y en 11 animales cebú Gobra (Bos indicus), para averiguar la susceptibilidad de raza a garrapatas adquirida de forma natural. Se utilizó la prueba ELISA para averiguar la prevalencia serológica frente al antígeno deAnaplasma marginale y frente al anticuerpo deBabesia bigemina. También se determinó el volumen corpuscular celular y se anotaron las ganancias de peso vivo. Se encontraron números significativamente mas altos deAmblyomma variegatum (p 〈 0·002) eHyalomma spp. (p 〈 0·001) en el ganado cebú Gobra que en animales N'dama. La prevalencia serológica del antígeno frente aA. marginale fue significantivamente menor en ganado N'dama, no encontrándose diferencia en la prevalencia serológica de anticuerpos frente aBabesia bigemina entre ambas razas. La infección afectó negativamente al volumen corpuscular celular en ambas razas, dicho descenso siendo menor en el ganado N'dama. La ganancia de peso vivo fue significativamente mayor (p 〈 0·003) en el ganado N'dama que en el Gobra durante el período de abundancia de adultos deA. variegatum eHyalomma spp. El hecho de que la carga de las garrapatasA. variegatum eHyalomma spp. fuera significativamente menor en el ganado N'dama que en el cebú Gobra en Gambia viene a confirmar los resultados anteriores. También se demuestra que el efecto de las garrapatas y las enfermedades transmitidas por garrapatas en la producción y salud animal es más perjudicial en el ganado cebú Gobra que en el N'dama. Se puede sugerir la existencia de un factor de resistencia a garrapatas en el ganado N'dama.
    Notes: Summary Tick collection on one side of the body and whole tail was performed weekly over one year on 11 Gambian N'Dama(Bos taurus) and 11 Gobra zebu(Bos indicus) cattle to assess breed susceptibility to naturally occurring ticks. Enzyme-linked immunosorbant assay was also performed to assess the serological prevalence ofAnaplasma marginale antigen andBabesia bigemina antibody. Packed red cell volume was measured and liveweight gain was recorded. Significantly higher numbers ofAmblyomma variegatum (P〈0·002) andHyalomma spp.(P〈0·001) were found on Gobra zebu than on N'Dama cattle. The serological prevalence ofA. marginale antigen was significantly(P〈0·001) lower in N'Dama breed, whilst no difference in the serological prevalence ofB. bigemina antibody was found between N'Dama and Gobra cattle. Packed red cell volume was negatively affected byA. marginale infection in both breeds, but to a lesser extent in N'Dama cattle. Liveweight gain was significantly(P〈0·003) higher in N'Dama in comparison with Gobra cattle during the period of abundance ofA. variegatum andHyalomma spp. adults. The significantly lower burdens ofA. variegatum andHyalomma spp. ticks in Gambian N'Dama in comparison with Gobra zebu cattle confirms previous findings. It also shows a more deleterious effect of ticks and tick-borne diseases on animal production and health in Gobra zebu than in N'Dama cattle. The presence of a tick resistant trait in N'Dama cattle is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02236320
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  • 7
    Electronic Resource
    Electronic Resource
    Comparison of characteristics of life cycle in female ticks collected on n'dama and zebu cattle (1995)
    Springer
    Tropical animal health and production 27 (1995), S. 150-154 
    Details
    ISSN: 1573-7438
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les auteurs ont étudié en laboratoire les caractéristiques du cycle vital des tiques femelles (Amblyomma variegatum, Hyalomma truncatum etBoophilus geigyi) nourries de la période d'oviposition jusqu'au stade du développement larvaire, sur du bétail de race Ndama et Zebu. Le pourcentage d'oeufs éclos d'Amblyomma variegatum et le poids des femelles gorgées deHyalomma truncatum étaient plus faibles chez les tiques récoltées sur le bétail Ndama que sur les Zebus. Les résultats au laboratoire ont confirmé les observations de terrain sur le caractère lié à l'espèce de la résistance spécifique aux tiques de la race Ndama.
    Abstract: Resumen Se estudiaron en el laboratoria las características del ciclo de vida de garrapatas hembras (Amblyomma variegatum, Hyalomma truncatum yBoophilus geigyi), alimentadas en ganado N'dama y cebú desde el período de oviposición hasta el desarrollo de la larva. El porcentaje de los huevos deA. variegatum eclosionados y el peso de las garrapatas adultas ingurgitadas de H. truncatum fueron inferiores en las garrapatas recolectadas en ganado N'dama que en cebú. Los resultados de laboratorio confirmaron las observaciones de campo sobre la existencia de una resistencia a las garrapatas especifica de especie en el ganado N'dama.
    Notes: Summary Characteristics of the life cycle of female ticks (Amblyomma variegatum, Hyalomma truncatum andBoophilus geigyi) fed on N'Dama and zebu cattle were studied in the laboratory from pre-oviposition period to larval development. Percentage ofA. variegatum eggs hatched and engorgement weight ofH. truncatum were lower in ticks collected on N'Dama than on zebu cattle. Laboratory results confirmed field observations of species specific tick resistance in the N'Dama breed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02248959
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  • 8
    Electronic Resource
    Electronic Resource
    Frequency of trypanosomosis and gastrointestinal parasites in draught donkeys in the Gambia in relation to animal husbandry (1994)
    Springer
    Tropical animal health and production 26 (1994), S. 102-108 
    Details
    ISSN: 1573-7438
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé La prévalence de la trypanosomose, des strongles gastrointestinaux et la quantité d'oeufs de strongles émis ont été étudiées en relation avec les pratiques d'élevage dans une population d'ânes de trait en Gambie. Le régime alimentaire, le nombre d'heures de travail par jour et la mise en enclos des ânes la nuit ont eu une influence significative (P〈0,05) sur le taux d'oeufs de strongles émis, mais non sur la prévalence de la trypanosomose (P〉0,05). La trypanosomose et la strongylose ont réduit de façon significative l'hématocrite (P〈0,001). Les animaux atteints de strongylose seulement n'ont pas présenté un hématocrite significativement plus bas (P〉0,05) que ceux indemnes. Des pratiques d'élevage destinées à améliorer la situation sont recommandées.
    Abstract: Resumen Se estudió la prevalencia de tripanosomosis, estróngilus gastrointestinales y su nivel de ovipostura, en relación con el manejo, en una población de burros de trabajo en Gambia. El régimen alimentario, el número de horas de trabajo por día y las prácticas de estabulación nocturnas, afectaron significativamente (P〈0·05) el nivel de ovipostura de parásites estrongilus, pero no la prevalencia de tripanosomosis (P〉0·05). Las infecciones duales de tripanosomas y estróngilus, redujeron significativamente el volumen corpuscular celular (VCC) (P〈0·001). Los animales positivos únicamentea estróngilus gastrointestinales, no presentaron reducciones significativas (P〉0·05) del VCC, comparados con aquellos encontrados negativos. Se recomiendan prácticas de manejo para mejorar la situación.
    Notes: Summary Prevalence of trypanosomosis, gastrointestinal strongyles and level of strongyle egg outputs were studied in relation to husbandry practices in the draught donkey population in The Gambia. Feeding regime, number of working hours per day and overnight penning practices of donkeys affected significantly (P〈0·05) the level of gastrointestinal strongyle egg output, but not (P〉0·05) trypanosomosis prevalence. Dual trypanosome and gastrointestinal strongyle infection significantly reduced the PCV (P〈0·001). Animals positive for gastrointestinal strongyles alone did not show a significantly (P〉0·05) lower PCV than those found negative. Husbandry practices to improve the situation are recommended.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02239909
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