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  • 1
    Electronic Resource
    Electronic Resource
    USE OF SILICONE RUBBER MEMBRANE ENCLOSURES FOR PREPARATION OF ERYTHROPOIETIN ASSAY MICE (1968)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 149 (1968), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1968.tb15132.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    DISCUSSION (1968)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 149 (1968), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1968.tb15175.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Regulation of Megakaryocytopoiesis by Thrombopoietin (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 509 (1987), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1987.tb30978.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Thrombopoietin from human embryonic kidney cells causes increased thrombocytopoiesis and decreased erythropoiesis in mice (1994)
    Springer
    Comparative clinical pathology 4 (1994), S. 63-69 
    Details
    ISSN: 1433-2981
    Keywords: Anaemia ; Megakaryocytes ; Stem-cell competition ; Thrombocytopoiesis ; Thrombopoietin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recent studies have shown that large doses of erythropoietin (EPO) administered daily over a 7-day period elevate erythropoiesis and lead to marked thrombocytopenia. Conversely, anaemia was found in mice following stimulation of thrombocytopoiesis by an acute thrombocytopenic episode. Although erythropoiesis and thrombocytopoiesis have been studied in mice after treatment with either hypoxia or EPO injection, only the effects of endogenous thrombopoietin (released after an acute episode of thrombocytopenia caused by an injection of antiplatelet serum) on erythropoiesis have been investigated. Therefore, we injected mice with a potent source of thrombopoietin and evaluated both thrombocytopoiesis and erythropoiesis at 3 and 5 days after treatment. The data show that thrombopoietin elevated thrombocytopoiesis with a concomitant reduction in erythropoiesis. We found significantly elevated percentage 35S incorporation into platelets, platelet sizes, and total circulating platelet masses following thrombopoietin injections at both 3 and 5 days; haematocrits, reticulocyte counts, and total circulating red blood cell masses were reduced significantly in these same mice. Compared to controls treated with human serum albumin, megakaryocyte size was increased on day 3, and megakaryocyte numbers were elevated on day 5 in mice treated with thrombopoietin. Thrombopoietin did not change the blood volume of mice, but did cause an increase in splenic weight. However, splenic sequestration of red blood cells was not the cause of anaemia in mice treated with thrombopoietin, since splenectomised mice also showed increased thrombocytopoiesis with decreased erythropoiesis. These data agree with previous studies showing an inverse relation between erythropoiesis and thrombocytopoiesis, and are consistent with the hypothesis that the erythrocytic and megakaryocytic cell lines are in competition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00368271
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    Paper (German National Licenses)
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