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  • 1
    Electronic Resource
    Electronic Resource
    Gastrointestinal Hormones (1978)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Medicine 29 (1978), S. 307-318 
    Details
    ISSN: 0066-4219
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.me.29.020178.001515
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  • 2
    Electronic Resource
    Electronic Resource
    Role of Gastrin in Hypersecretory Disorders in Man (1974)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Medicine 25 (1974), S. 233-249 
    Details
    ISSN: 0066-4219
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.me.25.020174.001313
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Review article: diagnosis and management of night-time reflux (2004)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 20 (2004), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Symptoms of gastro-oesophageal reflux disease (GERD) range from mild to severe and, when they occur during night-time hours, can interfere with sleep patterns and reduce overall quality of life. The clinical presentation of GERD is characterized by oesophageal as well as supra-oesophageal symptoms, including otolaryngologic and pulmonary complications. However, GERD may be overlooked as the cause of a patient's supra-oesophageal symptoms because these complaints can occur in the absence of oesophageal symptoms or endoscopic changes. The role of available tools used for GERD diagnosis, including endoscopy, oesophageal pH monitoring and an empirical course of proton pump inhibitor therapy, is discussed. Interventions available to achieve the therapeutic goals of symptom relief and prevention include specific lifestyle modifications and over-the-counter as well as prescription pharmacological agents. Patient-initiated, as-needed treatment may not be the best choice for managing persistent night-time reflux because it requires patient arousal from sleep. Proton pump inhibitor therapy remains the treatment of choice for patients with more severe symptoms and those with erosive oesophagitis. Few studies have specifically evaluated the role of pharmacological agents in the management of night-time reflux and comparisons are difficult due to the variability in study design and endpoints assessed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2004.02241.x
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  • 4
    Electronic Resource
    Electronic Resource
    Immunochemical differentiation between gastrin and related peptide hormones through a novel conjugation of peptides to proteins (1971)
    Springer
    Cellular and molecular life sciences 27 (1971), S. 514-515 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Nachweis, dass mit Hilfe von 2,4-Dichlor-6-methoxy-1,3,5-triazin Tyrosinreste von Peptiden und Lysinreste von Proteinen miteinander verknüpft werden können. Auf dieser Basis wurde ein immunologischer Test für die Sequenz 1–13 von menschlichem Gastrin entwickelt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02147570
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  • 5
    Electronic Resource
    Electronic Resource
    Functional and anatomical relationships between antral gastrin cells and gastrin-releasing peptide neurons (1985)
    Springer
    Histochemistry and cell biology 82 (1985), S. 463-467 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The present studies were directed to examine the effect of gastrin-releasing peptide (GRP) on β-adrenergic stimulated gastrin release by cultured rat antral mucosa and to assess the anatomical relationship between gastrin cells and GRP nerves in rat and human antrum. Peptide-containing cells were identified by application of an avidinbiotin-peroxidase immunocytochemical double staining method utilizing antibodies to GRP and gastrin prepared in rabbits. Rat antral mucosa was cultured for 60 min and gastrin released into the culture medium was measured by radioimmunoassay. Inclusion of antibodies to GRP in culture medium did not affect carbachol-stimulated gastrin release, whereas isoproterenol-stimulated gastrin release into the medium was inhibited significantly by addition of GRP antiserum to the culture medium. GRP-containing neurons and axonal fibers were stained immunocytochemically with diaminobenzidine (reddish-brown specific staining) and were located in the lamina propria adjacent to and surrounding the main lobules of antral glands. After double staining utilizing 4-Cl-1-Naphthol as substrate, blue stained gastrin-containing cells were identified in the middle and deeper regions of antral glands in close proximity to GRP neuronal elements. These studies suggest that β-adrenergic, but not cholinergic, stimulation of gastrin release is mediated, at least in part, through GRP. They also demonstrate intimate anatomical, as well as functional, relationships between gastrin cells and GRP-containing neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02450481
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of human gastrin infusion on gastric potential difference in man (1980)
    Springer
    Digestive diseases and sciences 25 (1980), S. 865-868 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Human gastrin I heptadecapeptide, infused intravenously to healthy volunteers in a dose of 0.5 μg/kg/hr, caused a prompt, significant reduction in gastric potential difference (decrease of mucosal negativity), with the peak change at 6 min. This decline in potential difference occurred at a time when the serum gastrin level was between 24 and 83 pg/ml; at the same time, scanning electron microscopic examination of fractographs of parietal cells demonstrated marked increase in canalicular membrane area. This study shows that the decrease in potential difference after gastrin occurs with serum gastrin levels which are in the physiologic range.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01338529
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  • 7
    Electronic Resource
    Electronic Resource
    Serum gastrin concentrations following oral bethanechol with and without a meal (1978)
    Springer
    Digestive diseases and sciences 23 (1978), S. 225-228 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present study was performed to test the effect of oral bethanechol (B) on endogenous gastrin release, both basally and in association with the physiologic stimulus of a protein meal. Serum gastrin levels were obtained from 10 normal subjects following: (1) an oral placebo; (2) an oral dose of 25 mg of B; (3) a 100-g protein meal plus placebo; and (4) a 100-g protein meal plus 25 mg of B. Following B or placebo there were no significant changes in basal serum gastrin levels of 98.7±29.3 (±se) pg/ml and 82.4±12.3 pg/ml, respectively. Significant increases of serum gastrin occurred after the protein meal (P〈0.01) and after the protein meal combined with B. The gastrin levels thus obtained were significantly greater than basal values but not different from each other. It is proposed that LES pressure increases following B are not due to the release of endogenous gastrin as shown by the absence of increases in basal serum gastrin levels and failure to augment the gastrin release of a physiologic stimulus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01072322
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  • 8
    Electronic Resource
    Electronic Resource
    A study of antibody production for the radioimmunoassay of gastrin (1977)
    Springer
    Digestive diseases and sciences 22 (1977), S. 902-908 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Gastrin conjugated to bovine serum albumin was administered to New Zealand white rabbits by repeated injections at a standard immunizing dose of 2 mg BSA-gastrin conjugate, as well as at 0.2 mg (10%) and 0.02 (1%) of BSA-gastrin conjugate. The intermediate dose of immunogen (0.2 mg) was also given by multiple simultaneous intradermal injections, with one later booster immunization. Resultant antisera from footpad injected rabbits were found to be of comparable high affinity, which was uninfluenced by the size of the administered dose of antigen conjugate. Antibody binding sites concentrations in these antisera, however, were found to be proportional to immunizing dose. Antibodies to gastrin produced after intradermal injection, although of comparable serum antibody concentrations, were of significantly lower affinity than after footpad immunization. It is concluded that high affinity antisera suitable for use in radioimmunoassay of gastrin can be produced by footpad immunization utilizing a small fraction of the standard immunizing dose of gastrin-bovine serum albumin conjugate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01076167
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