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  • 1
    Digitale Medien
    Digitale Medien
    Multicomponent dye adsorption onto carbon using a solid diffusion mass-transfer model (1991)
    s.l. : American Chemical Society
    Industrial & engineering chemistry research 30 (1991), S. 385-395 
    Details
    ISSN: 1520-5045
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/ie00050a016
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  • 2
    Digitale Medien
    Digitale Medien
    Solution to homogeneous diffusion mass transport equation (1984)
    s.l. : American Chemical Society
    Industrial and engineering chemistry 23 (1984), S. 181-182 
    Details
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/i200024a031
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  • 3
    Digitale Medien
    Digitale Medien
    External mass transfer and homogeneous solid-phase diffusion effects during the adsorption of dyestuffs (1984)
    s.l. : American Chemical Society
    Industrial and engineering chemistry 23 (1984), S. 221-226 
    Details
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/i200025a005
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  • 4
    Digitale Medien
    Digitale Medien
    Adsorption Kinetics and Diffusional Mass Transfer Processes during Color Removal from Effluent Using Silica (1978)
    s.l. : American Chemical Society
    Industrial and engineering chemistry 17 (1978), S. 406-410 
    Details
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/i260068a005
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  • 5
    Digitale Medien
    Digitale Medien
    Fluidization Characteristics of Cuboids (1980)
    s.l. : American Chemical Society
    Industrial and engineering chemistry 19 (1980), S. 712-715 
    Details
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/i260076a034
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  • 6
    Digitale Medien
    Digitale Medien
    Application of Surface Diffusion Model to the Adsorption of Dyes on Bagasse Pith (1998)
    Springer
    Adsorption 4 (1998), S. 361-372 
    Details
    ISSN: 1572-8757
    Schlagwort(e): dyestuffs ; modeling ; HSDM ; equilibeium ; film diffusion
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Physik , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Abstract A homogeneous solid phase diffusion model (HSDM) has been developed using a computer to predict the performance of a batch adsorber. The computer program utilises a semi-analytical solution for a two resistance model based on external mass transfer and homogeneous solid phase diffusion. The model has been successfully applied to four adsorption systems, namely, the adsorption of AB25, AR114, BB69 and BR22 onto pith. The method produces excellent correlations between experimental and theoretical concentration decay curves in batch adsorbers. The model developed presents a solution using a single solid diffusion coefficient and a single external mass transfer coefficient which are sufficient to characterise the system within a range of initial dye concentration, 25–300 mg · dm3 and solid/liquid ratios (w/v) 0.25–2.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1008854304933
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  • 7
    Digitale Medien
    Digitale Medien
    A pharmacokinetic study of trifluoperazine in two ethnic populations (1988)
    Springer
    Psychopharmacology 95 (1988), S. 333-338 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Trifluoperazine ; Pharmacokinetics ; Population ; Kurtosis ; Skewness ; Blacks (negro) ; Whites (caucasian)
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The single dose pharmacokinetics of trifluoperazine (5 mg, Stelazine) were investigated in black (n=25) and white (n=32) healthy male subjects. Plasma samples were harvested over 24 h and analysed by a GLC-MS method. There were wide intersubject variations in all pharmacokinetic parameters examined, including C max, AUC, apparent oral volume of distribution at steady state, and elimination half-life. For each of these parameters the distribution was positively skewed in both blacks and whites and the geometric mean gave a better estimate of central tendency than the corresponding arithmetic mean. In all pharmacokinetic parameters examined there was no significant difference detected between black and white subjects or between smokers and non-smokers.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00181943
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  • 8
    Digitale Medien
    Digitale Medien
    Variation in the single dose pharmacokinetics of fluphenazine in psychiatric patients (1988)
    Springer
    Psychopharmacology 96 (1988), S. 206-211 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Fluphenazine ; Pharmacokinetics ; Interpatient variation ; Kurtosis ; Skewness ; Blacks (negro) ; Whites (caucasian) ; Biliary recycling ; Fluphenazine conjugates
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The single dose pharmacokinetics of fluphenazine (2 × 5 mg tablets, Prolixin) were studied in 21 drug free male psychiatric patients (12 black, 9 white). Plasma samples were harvested over a period of 48 h while the patients were on a strictly controlled diet. The results showed wide interpatient variations in all pharmacokinetic parameters including Cmax, AUC, apparent oral clearance, and elimination half-life. It was determined for each of these parameters that the geometric mean gave a better estimate of central tendency than the corresponding arithmetic mean and the distribution was skewed and leptokurtotic. There was no significant difference between blacks and whites in any pharmacokinetic parameter examined. Considerable variations and marked undulations in the elimination portion of the plasma concentration versus time profiles were evident, possibly indicating biliary recycling of the drug. These undulations made it difficult to determine elimination rate constants for several of the patients. Hydrolysis or plasma samples from one patient demonstrated that the conjugate(s) of fluphenazine was present in three to four times the concentration of the unchanged drug.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00177561
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  • 9
    Digitale Medien
    Digitale Medien
    Fluphenazine plasma levels in patients receiving low and conventional doses of fluphenazine decanoate (1986)
    Springer
    Psychopharmacology 88 (1986), S. 480-483 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Schizophrenia ; Neuroleptic ; Fluphenazine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Plasma fluphenazine concentrations (FLU) were measured in 45 patients with schizophrenic disorders who participated in a double-blind comparison of 5 and 25 mg fluphenazine decanoate (FD). The rise in plasma level of FLU 24 h after a “test dose” was significantly correlated with steady state FLU concentration at 12 weeks (for 5 mg patients, r=0.45, P=0.04; for 25 mg, r=0.78, P=0.005). Patients who had low FLU at baseline required nearly 6 months to reach a steady state when they received 25 mg. Patients who received 5 mg and had low FLU at baseline continued to demonstrate relatively low plasma levels for the entire 1st year. Although the mean FLU at 6 months was lower for patients who relapsed during the subsequent 18 months (0.57 ng/ml for relapsers vs 1.01 ng/ml for nonrelapsers), this difference was not statistically significant. When plasma levels from both dosage groups were combined, FLU at 12 weeks correlated significantly with factor scores for akinesia (r=0.52, P=0.002) and BPRS cluster scores for retardation (r=0.52, P=0.002). These results indicate that the measurement of fluphenazine plasma levels may be useful in determining when patients treated with FD are receiving drug doses which are likely to cause discomforting side effects.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00178510
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  • 10
    Digitale Medien
    Digitale Medien
    The sulfoxidation of fluphenazine in schizophrenic patients maintained on fluphenazine decanoate (1987)
    Springer
    Psychopharmacology 93 (1987), S. 369-373 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Schizophrenia ; Fluphenazine decanoate ; Metabolic sulfoxidation ; Fluphenazine sulfoxide
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Highly sensitive radioimmunoassays were applied to study the sulfoxidation of fluphenazine in 30 schizophrenic patients maintained on either 5 mg or 25 mg fluphenazine decanoate by intramuscular injection every 14 days over a period of 6 months. The presence of the sulfoxide metabolite was detected in all but one of the patients, such that 97% of the 340 plasma samples analysed contained the metabolite. Interpatient variations in plasma levels of fluphenazine, fluphenazine sulfoxide, and in drug to metabolite plasma level ratios were several fold higher than the corresponding intrapatient variations at both dosages. There were statistically significant tendencies for mean plasma fluphenazine levels to rise and mean plasma sulfoxide levels to fall over the 6-month period of study among patients on the high dose, consistent with our previously reported observation that it takes 3–6 months to establish a steady state of fluphenazine with this dosage regimen. By contrast, there were no statistically significant changes in mean plasma levels of either fluphenazine or its sulfoxide in patients on the low dose. Nevertheless, there was a significant rise in fluphenazine to fluphenazine sulfoxide mean plasma level ratios in both dosage groups. It is difficult to assess the significance of the changes in the drug to metabolite ratios with time, since there are no kinetic data on the phase II metabolism (conjugation) of fluphenazine or fluphenazine sulfoxide. This study shows that sulfoxidation is an important major pathway in the metabolism of intramuscularly-administered fluphenazine, and implies that metabolic sites other than gut wall are also involved in the process.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00187259
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