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  • 1
    Electronic Resource
    Electronic Resource
    Recovery of the rabbit retina after light damage (preliminary observations) (1980)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 212 (1980), S. 271-283 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The retinae of anaesthetised Dutch rabbits were exposed to one of two intensities of white light for a period of 1 h. After exposure the animals were allowed to recover for various periods up to 4 weeks. The animals were then killed, and retinal and choroidal tissue was taken for investigation by both light and electron microscopy. Exposure to the lower intensity produced disruption of the visual cell outer segments and distension of the pigment epithelium. Recovery from this insult was rapid although disturbances in rod disc stacking and a loss of cone cell outer segments were evident 4 weeks after exposure. Exposure to the higher intensity resulted in necrosis of visual cells and pigment epithelial cells. Non-native phagocytic cells were active in the removal of cellular debris. Recovery from this insult was not observed. Four weeks after exposure much of the previously illuminated retina was reduced to disorganised Müller cells and occasional macrophages.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410521
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Extensive subretinal pigment epithelial deposit in two brothers suffering from dominant retinitis pigmentosa (1986)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 224 (1986), S. 299-309 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The eyes of two brothers with retinitis pigmentosa were removed after death and examined by a variety of techniques, including conventional histology, fluorescence microscopy and both scanning and transmission electron microscopy. Their condition was considered to be of an autosomal dominant type but with some atypical clinical features. The outstanding histological feature in both pairs of eyes was a predominantly acellular deposit of amorphous material situated between the retinal pigment epithelium and Bruch's membrane. This material extended from the disc to beyond the ora serrata. In some regions of the retinae of both brothers, there was a cellular infiltrate into the deposit and this included multinucleate cells. In one brother the deposit was lined externally by a fibrovascular membrane in some few locations. All retinae were degenerate, but all showed preservation of abnormally short and sparse photoreceptor cells in both the peripheral and macular areas. There was only patchy loss of the choriocapillaris, which could have been age-dependent rather than disease-dependent, and the remaining choroidal vessels were patent in all cases. The widespread distribution of the deposit is unusual and suggests that it arises from disordered metabolism of the retinal pigment epithelium. We could not determine whether it was a primary disease process or if it arose as a secondary phenomenon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02143075
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Short-term organ culture of the retinal pigment epithelium in microtitration plates: Ultrastructural studies (1986)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 224 (1986), S. 401-406 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Microtitration plates were used to culture simultaneously multiple, small (6 mm diameter) explants of bovine retinal pigment epithelium (RPE). Evaluation of tissue by light microscopy and by scanning and transmission electron microscopy after various incubation periods up to 6 h showed that RPE maintained in this system retains near normal morphology. Initially, the explanted RPE lacks apical microvilli, but during the first 2–3 h in culture recovery of apical microvilli occurs. The results suggest that the system is suitable for short-term maintenance of RPE for experimental purposes. Moreover, the ability to culture up to 16 explants from one bovine eye aids statistical evaluation of RPE behaviour under varying experimental conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02173353
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Light damage to the retina (1977)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 203 (1977), S. 283-292 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The retinae of anaesthetised Dutch rabbits were exposed to light of various known intensities for a period of 1 h. After this period the animals were sacrificed and tissue taken for investigation by light and electron microscopy. Changes were apparent in the visual cells and retinal pigment epithelium only at the highest intensities employed. The retinal pigment epithelium and the outer nuclear layer exhibited mild oedematous changes. The major components to be affected were the visual cell outer segments. Marked disruption and vesiculation were features of the cone outer segments, which was in distinct contrast to the focal damage observed in the rod outer segments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00409834
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Some aspects of radiant energy damage to the retina (1978)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 208 (1978), S. 109-124 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The retinae of anaesthetised Dutch rabbits were exposed to white light of various intensities* (* 67–235 mW/cm2 measured at 2.5 cms from the end plate of the light guide) for a period of one h. After this period the animals were killed and tissue taken for investigation by light and electron microscopy. The higher intensities produced marked disruption of the visual cell outer and inner segments as well as a variety of morphological changes in the pigment epithelium. The highest intensity produced severe disruption of the visual cells and pigment epithelium in addition to a general disruption of the other retinal layers. Accompanying the retinal damage there was an inflammatory response in the choroid of the experimental eyes and surprisingly, at some intensities, a similar inflammatory response in the choroid of the control eye.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406986
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Qualitative observations on the variation of light induced damage to the rabbit retina (1981)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 215 (1981), S. 305-325 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The retinae of anaesthetised Dutch rabbits were exposed to light of various known intensities for one hour. Immediately after exposure the animals were killed and retinal and choroidal tissues were taken for investigation by electron microscopy from selected sites within the previously illuminated area. Initial qualitative observations suggested that a considerable variation in the degree of cellular damage had occurred even within retinal and choroidal tissues taken from the same eye. This variability of damage appeared to be related to intensity of illumination and patency of the choroidal vasculature. The mechanisms which could be underlying this variation of damage and possible methods of quantification are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00407669
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    Paper (German National Licenses)
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