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  • 1
    Electronic Resource
    Electronic Resource
    Factor analysis of the psychosocial items of the EORTC QLQ-C30 in metastatic breast cancer patients participating in a psychosocial intervention study (1999)
    Springer
    Quality of life research 8 (1999), S. 311-317 
    Details
    ISSN: 1573-2649
    Keywords: Breast cancer ; Quality of life ; Questionnaire ; Validation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The underlying factor structure of a subset of 12 items, which comprise the psychosocial subscales of the EORTC QLQ-C30 was explored in a group of women, all with metastatic breast cancer who were participating in a psychosocial intervention study. Two main factors were identified in this exploratory factor analysis, representing “emotional distress” and “functional ability” dimensions. A preliminary assessment of the external validity of the two factor structure was undertaken. The results support the validity of a summative “emotional distress” and “functional ability” score in this sample of patients. The “functional ability” score discriminated well for subgroups defined by clinical status indicators (e.g., performance status, pain, chemotherapy treatment, fatigue). The “emotional distress” subscale discriminated with respect to suffering, fatigue and sleep disturbance. Both subscales converged with related concepts measured by independent instruments, providing support for convergent validity. Summative index scores may be advantageous for application in particular research situations; applying quality adjustments in health policy analyses; for screening purposes; to monitor populations and make comparisons across broad groups and as stratification variables in clinical trials. Further research to confirm the 2 factor structure is required in other samples before the interpretation can be accepted with confidence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008939818096
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Male breast cancer: An 11 year review of 66 patients (1996)
    Springer
    Breast cancer research and treatment 40 (1996), S. 225-230 
    Details
    ISSN: 1573-7217
    Keywords: breast cancer ; male ; case series
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A review was conducted of 66 men with carcinoma of the breast seen at this institution between 1981 and 1992. The results of the study suggest that there are many similarities between breast cancer in men and women. The most common clinical presentation was a lump in the breast. The majority of tumors were T1 or T2, and infiltrating ductal carcinoma was the predominant histological type. Axillary nodal status and histological grade were predictive of survival. The pattern of recurrence and survival rates were similar to those seen in women. Some differences, however, were evident. Tumors were centrally located in the majority of patients and there was a high frequency of nipple involvement. The hormone receptor positivity rate was high and the median age at presentation was older. In comparison to a previous report of the same disease from this institution 10 years ago, fewer patients underwent radical surgical procedures and more patients received adjuvant systemic therapy. These approaches are justified since there are many biological similarities between breast cancer in men and women.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01806810
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Third line chemotherapy in patients with metastatic breast cancer: an evaluation of quality of life and cost (1999)
    Springer
    Breast cancer research and treatment 54 (1999), S. 213-223 
    Details
    ISSN: 1573-7217
    Keywords: costs ; metastatic breast cancer ; quality of life
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Many patients with metastatic breast cancer receive several types of chemotherapy, although it is recognized that there is a declining probability of response. A major problem confronts oncologists in deciding when to recommend to patients that no further chemotherapy should be given. To address this problem we have assessed prospectively, health‐related quality of life (HRQL) and costs of health care for 35 patients with metastatic breast cancer receiving third line chemotherapy in a representative clinical situation. HRQL and utilities were measured longitudinally using the EORTC QLQ‐C30 questionnaire and the time trade‐off method. Patients received a median of 2 cycles of chemotherapy and lived a median of 4.3 months. Twelve patients (34%) had substantial (〉 10 points) improvement in the Global QL subscale and more than 30% of patients had similar changes in emotional and social function. The median baseline utility score was 0.9 and utilities correlated poorly with HRQL subscale. Eighteen patients had measurable disease and one patients experienced a partial response. Grade 3/4 toxicity occurred in 30% of patients. The average cost of management from study entry to death was CDN$ 17,260 (~US$ 12,000). Sixteen percent of this cost was associated directly with chemotherapy while hospital admissions and outpatient visits accounted for 50% and 14% of the total cost respectively. We conclude that: (a) many patients receiving third line chemotherapy maintain or improve indices of HRQL despite short survival and a low response rate: this might be due to chemotherapy, paclebo effect, or a shift in frame of reference for HRQl; (b) patients were unwilling to trade quantity for quality of life; and (c) response rates and survival may be overestimated in patients selected for clinical trials.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006123721205
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    Paper (German National Licenses)
    Fulltext
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