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  • 1
    ISSN: 1530-0358
    Keywords: Laparoscopy ; Colon surgery ; Colon cancer ; Laparoscopic colon resections for cancer ; Outcomes of laparoscopic colon surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Laparoscopy for colonic diseases began in 1990 and has established a role in benign disease. Early observations and experiences demonstrated feasibility of laparoscopic surgery for a variety of colonic disease processes, but the applicability to colonic carcinoma was unclear. METHODS: In 1990, we began a comparative study of open (OCR) vs. laparoscopic (LCR) approach to colon cancer. The study progressed 65 months, with 224 patients in OCR group and 191 patients in LCR group. Parameters studied are stage, location, length of specimen, number of lymph nodes resected, margins, postoperative course, wound complications, recurrence rates, and immediate and long-term survival. OCR were standardized by one group, and LCR were standardized by a second group. All patients undergoing LCR were given freedom to choose either OCR or LCR, and informed consent was obtained. RESULTS: Equal or greater lymph node retrieval, resections, and distal margins were evident with LCR. Benefits with LCR were shown with shorter hospitalization (5.7 vs. 9.7 days), less blood loss, less wound problems (1 vs. 14), and quicker return of bowel function. Survival, recurrence, and death rates were essentially the same. There were no trocar implants in the LCR group. CONCLUSION: After five years, this study shows that laparoscopy does no harm to the patient, offers comparable oncologic resections, and seems to be patient-friendly, with less pain, quicker return of bowel functions, shortened hospitalization, and quicker return to full activity.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of mammary gland biology and neoplasia 5 (2000), S. 393-407 
    ISSN: 1573-7039
    Keywords: Preneoplasia ; hyperplastic alveolar nodule ; ductal hyperplasia ; biological phenotype ; molecular phenotype
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Preneoplastic lesions in murine mammary tumorigenesis have been extensively investigated over the past 50 years. The two general types of lesion that have malignant potential are the alveolar hyperplasias represented by the classical hyperplastic alveolar nodule and the ductal hyperplasias. The former type of lesion is induced by viral, chemical and hormonal agents; the latter by chemical agents and specific genetic alterations. Individual animal models have been utilized to elucidate the basic biological properties of the lesions and some of the basic molecular alterations. The biological phenotype of the two types of lesions include immortalization and epithelial hyperplasia. The ductal hyperplasias are distinguished from the alveolar hyperplasias by their pattern of epithelial hyperplasia and their extent of aneuploidy. The molecular alterations underlying epithelial hyperplasia are numerous and dependent on the particular animal model. An important issue for future studies is how faithfully any of these models mimic human premalignant progression. A minimal set of criteria is proposed that includes morphological progression, hormone dependence and genetic instability. It is likely that hyperplasias from a specific mouse model will represent a subset of the lesions found in human disease. Analogous hyperplasias from several defined genetic models, adequately characterized at the biological and molecular levels, would provide appropriate models for testing chemopreventive agents.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of mammary gland biology and neoplasia 5 (2000), S. 339-340 
    ISSN: 1573-7039
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of mammary gland biology and neoplasia 1 (1996), S. 135-136 
    ISSN: 1573-7039
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of mammary gland biology and neoplasia 1 (1996), S. 3-4 
    ISSN: 1573-7039
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of mammary gland biology and neoplasia 1 (1996), S. 5-19 
    ISSN: 1573-7039
    Keywords: Mammary gland ; development ; transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The microanatomy and development of the mammary gland are unique and a reflection of its function to synthesize and deliver milk to the newborn offspring. The uniqueness of the mammary gland resides in several factors. First, the mammary parenchyma undergoes the vast majority of its growth postpubertally, thus enabling experiments on development to be performed in the juvenile or adult and presenting opportunities for experimental manipulation of the gland not available with other organs. On the basis of this characteristic, the fat pad transplantation method was developed, which resulted in the elaboration of important concepts in senescence, immortalization, and preneoplasia. Second, the accessibility of the gland and the ductal organization allows delivery and localization of specific molecules to mammary parenchyma cells, the cells which are the site of origin of neoplastic development. Third, the organ is the target of viral, chemical, and physical carcinogens, allowing development of unique and complex models for neoplastic development. Finally, the complexity of hormone and growth factor regulation of mammary gland function allows a sophisticated approach to the study of hormone action. The purpose of this review is to illustrate some unique properties of the gland which provide the basis for specialized approaches to developmental, neoplastic, and functional problems.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-7217
    Keywords: steroid receptor coactivators ; mammary gland ; mammary tumorigenesis ; E6-AP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Steroid receptor coactivator and corepressor proteins are important mediators of steroid receptor function. Changes in the expression or activity of these limiting cofactors can contribute to the etiology of steroidal cancers. Using a mouse mammary model of multistage tumorigenesis we have examined whether the expression of select steroid receptor coactivators is altered. The 10 kb transcript of the novel dual function steroid receptor coactivator/ubiquitin protein-ligase integrator E6-AP is overexpressed 2.5–4.5 fold in the mammary tumors but not in the precursor steps of tumorigenesis; that is, immortal ductal and alveolar hyperplastic outgrowths. The over expression is striking because the 10 kb transcript is expressed to variable levels in other wild type tissues like the uterus, ovary, testis, kidney and brain but is undetectable in normal virgin mammary gland and the prostate gland. The E6-AP overexpression in the mammary tumors is substantiated by western blot analysis and immunohistochemical analysis. Absence of ER and PR in these tumors in the presence of high levels of E6-AP could contribute to steroid receptor-independent function and tumorigenesis. There is no obvious correlation between p53 (a well-characterized substrate of E6-AP) status (wt vs. mutant) and levels of E6-AP in the mouse mammary tumors.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Journal of mammary gland biology and neoplasia 3 (1998), S. 109-116 
    ISSN: 1573-7039
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The mammary fat pad is essential for developmentof the mammary epithelium, providing signals thatmediate ductal morphogenesis and, probably, alveolardifferentiation. The “cleared” fat pad is often used as a transplantation site.Considering the crucial role of the fat pad, itsproperties have received relatively little attentionfrom researchers in the field. Some of the questionswhose investigation is pertinent to understanding both normalmammary development and carcinogenesis are outlined inthis commentary in the spirit of stimulating enquiryinto this important subject. It is clear from a brief perusal of the available literature that untilstudies are specifically designed to clearlydifferentiate between functional effects of the fibrousand the adipose stroma, more substantive informationabout their differential effects on mammarydevelopment and tumorigenesis will not beforthcoming.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of mammary gland biology and neoplasia 3 (1998), S. 363-364 
    ISSN: 1573-7039
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 26 (1988), S. 2319-2330 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The use of the boundary-element method (BEM) for three-dimensional potential flow problems is described herein. The specific application for which the program is designed is the flow in fractured porous media. There are several enhancements to the usual boundary-element calculations. The method uses linear elements to approximate better the boundary conditions and the solution on the surfaces as compared to constant elements; accurate integration over high-aspect-ratio triangles is achieved by computing all the integrals in closed form, as opposed to numerical cubature or mixed exact-numerical integration schemes; and the zoning for inhomogeneous regions uses an efficient method which reduces the size of the problem and avoids difficulties with singularities.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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