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  • 1
    Electronic Resource
    Electronic Resource
    HLA-DR4-DQw8, but not DR4-DQw7 haplotypes occur in Indian patients with rheumatoid arthritis (1992)
    Springer
    Rheumatology international 11 (1992), S. 251-255 
    Details
    ISSN: 1437-160X
    Keywords: Rheumatoid arthritis ; HLA DR/DQ antigens ; DR4 subtypes ; HLA haplotypes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The distribution of HLA class II antigens in the Asian Indian patients with rheumatoid arthritis (RA) was studied in the present investigation. The results demonstrated that DR4 was significantly increased in both northern (χ2=36.9, P〈0.00001) as well as southern Indian (χ2=17.3, P〈0.0001) patients. HLA haplotype analysis revealed the presence of B17-DR4 among southern Indians. Amongst northern Indians, four DR4 haplotypes occurred significantly: A1,B17,DR4; A19,B7, DR4; A30,B13,DR4; and A33,B44,DR4. An analysis of TA10 and DQ'Wa' specificities revealed that all the DR4-DQw3 positive northern Indian RA patients were DQw8 positive association observed between DR4-DQw7 and RA in some western Caucasian populations was not present in this series. A group of three DR4 positive RA patients were found to be DQw3 negative and DQ'Wa' or DQw4 positive. These results indicated that susceptibility to RA may be controlled by genes in the DR locus independent of any DQ associations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00301502
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  • 2
    Electronic Resource
    Electronic Resource
    Reiter's disease in northern India (1983)
    Springer
    Rheumatology international 3 (1983), S. 101-104 
    Details
    ISSN: 1437-160X
    Keywords: Reiter's disease ; Sacroiliitis ; Histocompatibility antigens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirty-six patients fulfilling the criteria for Reiter's disease were studied (29 men and 7 women; 4:1). The mean age of onset was 23.8 years; in 75% of patients the onet was in the second and third decades. Clinical manifestations included low back pain and stiffness (69%), non specific urethritis (53%), heel pain (44%), radiographic sacroiliitis (42%), conjunctivitis (39%), dysentery and diarrhoea (33%), mucosal ulcerations (17%) kidney disease (14%), anterior uveitis (19%), and keratoderma blennorrhagicum (8%). Peripheral arthritis was mono or oligoarthritis in 58% of patients, mainly affecting the large joints of lower extremities, and it was often asymmetric (mean degree of asymmetry=0.37). HLA-B27 antigen was detected in 83% of 36 patients compared with 5.9% of 118 controls (relative risk 79, corrected Fisher's P=7.719E-18).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541187
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  • 3
    Electronic Resource
    Electronic Resource
    Clinical and immunogenetic studies in rheumatoid arthritis from northern India (1983)
    Springer
    Rheumatology international 3 (1983), S. 105-108 
    Details
    ISSN: 1437-160X
    Keywords: Rheumatoid arthritis ; Immunogenetics ; HLA-DR ; IgG rheumatoid factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A total of 258 patients with classic rheumatoid arthritis seen over a 7-year period were included in this study. The majority of the patients had relatively mild disease at the time of presentation. The incidence of extra-articular manifestations such as subcutaneous nodules, vasculitis, amyloidosis and pulmonary involvement was low although one or two pulmonary function test parameters were abnormal in some. Seventy patients were tested for all three subclasses of rheumatoid factors — IgM, IgG and IgA. Of these, 23 patients had all three whilst four had only IgG. The 62 patients who had most typical and severe manifestations were typed for four major HLA loci A, B, C and DR. Of these 42 (67.7%) had DR4 antigen while DR3 antigen was detected in 14 (22.6%).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541188
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  • 4
    Electronic Resource
    Electronic Resource
    Autoimmunity in type I (insulin-dependent) diabetes mellitus in North India (1981)
    Springer
    Journal of clinical immunology 1 (1981), S. 169-173 
    Details
    ISSN: 1573-2592
    Keywords: Insulin-dependent diabetes mellitus ; islet cell antibody ; organ-specific autoantibody ; HLA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pancreatic islet cell, thyroid, gastric parietal cell, and adrenal autoantibodies were studied in 110 young insulin-dependent diabetics (Type I; IDDM), 12 non-insulin-dependent diabetics (NIDDM), 26 patients with pancreatic diabetes, and 123 age- and sex-matched healthy controls. All the patients were aged 30 years or under at the onset of diabetes. Islet cell antibody was found in 31% of the patients with IDDM, but in only one patient with NIDDM, one patient with pancreatic diabetes, and one healthy control subject. Thyroid, parietal cell, and/or adrenal antibodies were present in 26% of the IDDM patients, 17% of the NIDDM patients, 12% of the patients with pancreatic diabetes, and 19% of the control subjects. There was no association between the presence of islet cell antibody and other organ-specific autoantibodies and any particular HLA phenotype. Data from the North Indian study have been compared with those from other populations of the world, similarities and differences have been brought out, and their significance has been discussed. The relative contribution of the autoimmune component in the etiopathogenesis of different forms of diabetes mellitus varies among the different populations of the world, accounting to some extent for the observed differences in incidence and clinical profiles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00922759
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  • 5
    Electronic Resource
    Electronic Resource
    Evaluation of quantitative sacroiliac scintigraphy for the early detection of sacroiliitis (1983)
    Springer
    European journal of nuclear medicine 8 (1983), S. 531-534 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Quantitative sacroiliac scintigraphy (QSS) was evaluated for the detection of sacroiliac (SI) joint disease before the appearance of radiographic/changes. QSS with fractional quantitation was done in 13 age- and sexmatched controls and 28 patients with different grades of radiographic sacroiliitis. The SI index of each joint was considered separately. The mean SI index values in patients with grade I radiographic sacroiliitis (1.54) and HLA-B27 positive patients with low back pain (1.50) were significantly (P〈0.01) higher than the mean SI index of controls (1.22); but more than 50% of their SI index values were within the 97.5% confidence limits of the control range. The mean SI index values of patients with grade II (1.38) and grade III (1.34) radiographic sacroiliitis did not differ significantly from the mean SI index of controls (P〉0.05). Thus a large overlap between the normal and abnormal ranges of sacroiliac ratios limits the utility of quantitative sacroiliac scintigraphy for the early diagnosis of sacroiliac joint disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00251615
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  • 6
    Electronic Resource
    Electronic Resource
    A Seasonal Assessment of the Impact of Coal Fly Ash Disposal on the River Yamuna, Delhi, II. Biology (1998)
    Springer
    Water, air & soil pollution 103 (1998), S. 315-339 
    Details
    ISSN: 1573-2932
    Keywords: fly ash ; heavy metals ; phytoplankton ; species diversity ; zooplankton ; water chemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The impact of fly ash on the biology of the Yamuna River, Delhi, was studied. Effluents come from a 200 MW capacity I.P. thermal power station. Seasonal variations in the biological features in the non-impacted (Y-1) and the impacted (Y-2) segments of the river receiving fly ash effluents were studied. 60 genera of phytoplankton including 29 Chlorophyceae, 19 Bacillariophyceae, 8 Cyanobacteria, and 4 Euglenophyceae were recorded. Phytoplankton diversity was reduced at the impacted site in comparison to the non-impacted site of the river and substantial changes in the composition of various groups inhabiting these areas were observed. Zooplankton were also reduced at Y-2 compared to Y-1, especially rotifers and protozoans, while copepods and nauplii larvae were not affected to the same degree. Species diversity was not significantly different at Y-2 and Y-1 but similarity index varied from low to high between the two stations. Thus, not only was the density, number of genera and diversity reduced, even the generic composition of the plankton was markedly affected in the impacted waters. The observed perturbations could be due to sedimentation of ash particles, pH or elevated metal or salt concentration. A change in the concentration of one or more constituents disturbs the relationship between biota and could be the possible cause of reduced densities in the impacted waters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1004991131709
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  • 7
    Electronic Resource
    Electronic Resource
    A Seasonal Assessment of the Impact of Coal Fly Ash Disposal on the River Yamuna, Delhi. I. Chemistry (1998)
    Springer
    Water, air & soil pollution 103 (1998), S. 277-314 
    Details
    ISSN: 1573-2932
    Keywords: fly ash ; elements ; water chemistry ; coal ash ; heavy metals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The impact of fly ash on the chemistry of the River Yamuna was studied. By-products from a 200 MW capacity I.P. thermal power station on the west bank of the River Yamuna, Delhi are largely from coal combustion (fly ash) and are disposed of as a slurry to off-site ash ponds. Many elements associated with fly ash are soluble and become available to the biota. A two-year survey was made of the seasonal variations in limnochemical features in the non-impacted and the impacted segments of the river receiving fly ash effluent and the ash treatment ponds. Conductivity, TDS, DO, hardness, sulphate and nitrate increased significantly in the receiving waters over background values. The reverse was noticed for free CO2, alkalinity and phosphate. Changes in some other parameters were insignificant. Fly ash effluents from the ash ponds significantly increased the concentration of some elements, viz., Al, Sb, Bi, Cd, Cr, Co, Li, Mn, Mo, K, Si, and Zn in river water. Generally, the highest concentration of most parameters were recorded in the ash ponds. This investigation was helpful in assessing the effect of wet ash disposal on the river limnology and understanding the solubility of various elements in the ash ponds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1004953715779
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