ISSN:
1573-2568
Keywords:
GASTROINTESTINAL ULCERATION
;
INDOMETHACIN
;
PASSIVE CIGARETTE SMOKING
;
GASTROINTESTINAL
;
BLOOD FLOW
;
MYELOPEROXIDASE
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Cigarette smoking and nonsteroidalantiinflammatory drugs (NSAIDs) have been associatedwith gastroduodenal ulcers. The present study aimed toclarify the ulcerogenic mechanisms of passive cigarettesmoking on gastrointestinal damage induced byindomethacin in fasted or in fasted and refed rats. Ratswere exposed to cigarette smoke (0%, 1%, 2%, or 4%, v/v)before and/or after indomethacin administration.Cigarette smoke dose-dependently potentiatedindomethacin-induced gastric mucosal lesions in thefasted animals and further lowered gastric blood flow.The gastric myeloperoxidase activity (a marker enzymefor neutrophils) was also potentiated. In addition, passivecigarette smoking increased the mortality and aggravatedduodenal ulceration and also the reduction of duodenalblood flow in the fasted and refed rats afterindomethacin treatment. The results indicated that thepotentiating effect of passive cigarette smoking onindomethacin-induced gastroduodenal lesions is probablydue to the depression of blood flow in thegastroduodenal mucosa and to the aggravation of neutrophilinfiltration in the gastric mucosa.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1026635908920
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