ISSN:
0170-2041
Keywords:
syn-δ-Tosyloxy-γ-lactones
;
anti-N-Boc-δ-amino-γ-lactones
;
Hydroxyethylene dipeptide isosteres
;
δ-Amino-γ-lactone → γ-hydroxy-δ-lactam rearrangement
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Tetrahydrofurans and γ-Lactones, VI. - Optically Active N-Boc-δ-Amino-γ-lactones from Cyclooctyne and FuranThe stereoselective synthesis of the title compounds (-)-(2′R,8S)-2b and (+)-(2′S,8R)-2b from (2′R,8R)1a and (2′S,8S)-1a is described. The unprotected amino lactone 2c undergoes rearrangement to the γ-hydroxy-δ-lactam 3a by treatment with hydrogen chloride.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199319930187
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