ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The functional properties of GABAB receptors were examined in the dorsal raphe nucleus (DRN) and the hippocampus of knock-out mice devoid of the 5-HT transporter (5-HTT–/–) or the 5-HT1A receptor (5-HT1A–/–). Electrophysiological recordings in brain slices showed that the GABAB receptor agonist baclofen caused a lower hyperpolarization and neuronal firing inhibition of DRN 5-HT cells in 5-HTT–/– versus 5-HTT+/+ mice. In addition, [35S]GTP-γ-S binding induced by GABAB receptor stimulation in the DRN was approximately 40% less in these mutants compared with wild-type mice. In contrast, GABAB receptors appeared functionally intact in the hippocampus of 5-HTT–/–, and in both this area and the DRN of 5-HT1A-knock-out mice. The unique functional changes of DRN GABAB receptors closely resembled those of 5-HT1A autoreceptors in 5-HTT–/– mice, further supporting the idea that both receptor types are coupled to a common pool of G-proteins in serotoninergic neurons.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-4159.2004.02367.x
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