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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 135 (1996), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The term ‘jingry back syndrome’ (ABS) was coined by Mitchell in 197S. It was.stated that a strong positive patch test reaclion could create an ‘angry back’ which becomes hyperretictiye to other patch test challenges. The present study investignled whether the ABS is a generalized state of hyper-reactivity of skin, whether it is a localized hyper-reactivity of skin. i.e. only in lhe close proximity to a strong patcli test reaction, whelhcr it is an individual specilic phenomenon and if ABS is a reproducible phenomenon. The studies failed lo demonstrate any generalized or localized change in the reactivity of the skin. This lell the possibility that ABS might be a rare, and individual-specilic phenomenon. However, even in the subjects who had previously been diagnosed as having ABS we failed to reproduce the angry back.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 144 (2001), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 142 (2000), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study examines the prevalence of sun-related damage to the skin in a caucasian population in north-west England. The importance of constitutional factors (complexion, skin type and age) as well as environmental and occupational exposures for the development of actinic keratosis (AK) and skin cancers was assessed in people over 40 years of age attending outpatient clinics (non-dermatology) at four centres in north-west England (Mersey region). Nine hundred and sixty-eight volunteers (531 men and 437 women) were recruited. The overall prevalence of AK was 15·4% in men and 5·9% in women. The prevalence was strongly related to age in both sexes, being 34·1% and 18·2%, respectively, in men and women aged 70 years and above, and was most strongly related to two objective signs of sun exposure, namely degree of solar elastosis and presence of solar lentigines. The prevalence of AK was higher in subjects with red hair and freckles, particularly women. There was no evidence of an increased prevalence of AK in relation to any occupation. There was a high prevalence of seborrhoeic keratosis and viral warts in both sexes, which was age-related in the case of seborrhoeic keratosis. Ten cases of basal cell carcinoma, eight cases of Bowen’s disease and one case of malignant melanoma were identified. This study shows that the sun exposure received in ‘normal’ life in England is sufficient to cause potentially malignant skin damage in a significant proportion of the population.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Diagnosis of allergic contact dermatitis depends upon the use of epicutaneous patch tests with suspected antigens. It has been claimed that the method is unreliable because of variability. Therefore, we have tested this by comparing responses to various forms of replicate, standardized challenge in nickel-sensitive subjects. Nickel-containing coins applied at 2-4 different sites on the back elicited similar responses in up to 95% of tests. Serial dilutions of nickel sulphate (NiS04) applied, in duplicate, gave highly reproducible responses on the back. However, the forearm skin was clearly less responsive. Examination of the effect of the quantity of nickel-containing vehicle showed that, above a certain minimal level, this had no effect on the reproducibility of the responses. In conclusion, the immune system can give highly reproducible responses when presented with standard eliciting stimuli.
    Type of Medium: Electronic Resource
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