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  • 1
    Electronic Resource
    Electronic Resource
    The course ofPlasmodium berghei infection in mice latently infected withToxoplasma gondii (1982)
    Springer
    Cellular and molecular life sciences 38 (1982), S. 570-571 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The course of infection with 2 different virulent strains ofPlasmodium berghei was investigated in mice latently infected withToxoplasma gondii. When given the highly virulent ANKA strain ofP. berghei all Toxoplasma-infected mice died but the survival time was prolonged. After infection with the less virulent strain K 173 mice could survive the subsequent infection. In these cases levels of parasitemia depended upon the duration of theT. gondii infection. Mice infected for about 6 weeks withT. gondii showed maximum protection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02327054
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    On the nephrotoxicity of α-amanitin and the antagonistic effects of silymarin in rats (1979)
    Springer
    Inflammation research 9 (1979), S. 221-226 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In human beings, poisoning by the deathcup mushroom causes renal lesions in addition to extremely severe liver damage. It is known from animal experiments that silymarin, a polyhydroxyphenylchromanone, is capable of counteracting this α-amanitin-induced liver damage. The purpose of the present work was to ascertain whether renal damage could be induced in rats by giving α-amanitin, and whether silymarin would have any effect on such renal damage. The fact that α-amanitin produces pathological changes in the kidneys and that these lesions can be almost completely prevented by pretreating rats with silymarin has now been amply demonstrated by biochemical and histological techniques alike.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02024739
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    On the histopathogenesis of rat forestomach carcinoma caused by aristolochic acid (1983)
    Springer
    Archives of toxicology 52 (1983), S. 209-220 
    Details
    ISSN: 1432-0738
    Keywords: Aristolochic acid ; Carcinogenesis ; Squamous cell carcinoma ; Forestomach ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The histopathogenesis of rat forestomach carcinoma induced experimentally with aristolochic acid was investigated. The intragastric administration of 10 mg/kg/day caused extensive necrosis of the squamous epithelium, followed by regeneration and hyperplasia, papilloma formation and ultimately by invasive squamous cell carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00333900
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  • 4
    Electronic Resource
    Electronic Resource
    Acute toxicity of aristolochic acid in rodents (1987)
    Springer
    Archives of toxicology 59 (1987), S. 328-331 
    Details
    ISSN: 1432-0738
    Keywords: Aristolochic acid ; Toxicology ; Acute toxicity ; Rat ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The acute toxic effects of aristolochic acid (AA) were tested in rats and mice of both sexes. Oral or intravenous administration in high doses was followed by death from acute renal failure within 15 days. Histologically, the predominant features were severe necrosis affecting the renal tubules, atrophy of the lymphatic organs and large areas of superficial ulceration in the forestomach, followed by hyperplasia and hyperkeratosis of the squamous epithelium. The LD50 ranged from 56 to 203 mg/kg orally or 38 to 83 mg/kg intravenously, depending on species and sex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00295084
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  • 5
    Electronic Resource
    Electronic Resource
    Acute phalloidin poisoning in dogs (1981)
    Springer
    Archives of toxicology 48 (1981), S. 61-67 
    Details
    ISSN: 1432-0738
    Keywords: Amanita phalloides ; Phalloidin ; Toxicity ; Liver ; Dogs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The acute toxic effects of phalloidin, a toxin from the green deathcup, Amanita phalloides, were tested in dogs. No fatalities occured following intravenous injection; however, the biochemical parameters GPT, GOT, alkaline phosphatase, and total bilirubin yielded pathological values. Histologically the liver parenchyma revealed hemorrhagic necrosis and peliosis-like changes with penetration of red blood cells into hepatocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00297076
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  • 6
    Electronic Resource
    Electronic Resource
    The carcinogenic action of aristolochic acid in rats (1982)
    Springer
    Archives of toxicology 51 (1982), S. 107-119 
    Details
    ISSN: 1432-0738
    Keywords: Aristolochic acid ; Toxicology ; Chronic toxicity ; Carcinogenicity ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Male and female Wistar rats treated orally with 0.1, 1.0 or 10.0 mg/kg/day aristolochic acid as its sodium salt (AA) developed a high incidence of tumours dependent on dose and time. After 3 months' treatment 1.0 and 10.0 mg/kg AA led to severe papillomatosis of the forestomach with occasional signs of malignancy. Three to 6 months later without further treatment the rats developed squamous cell carcinomas in the forestomach with formation of metastases. At the same time anaplasia of the tubular epithelium and mainly adenomas appeared in the renal cortex. The transitional epithelium of the renal pelvis and the urinary bladder showed hyperplasia, papillomas or carcinomas. For the low dose (0.1 mg/kg) the treatment with AA varied between 3 and 12 months. No tumours were observed in the first 6 months of the study. After 12 and 16 months, however, papillomas or squamous cell carcinomas also occurred in the forestomach. In addition, hyperplasia of the transitional epithelium of the renal pelvis was found while the renal cortex and the urinary bladder remained normal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00302751
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  • 7
    Electronic Resource
    Electronic Resource
    Tumour induction in mice following exposure to aristolochic acid (1988)
    Springer
    Archives of toxicology 61 (1988), S. 504-505 
    Details
    ISSN: 1432-0738
    Keywords: Aristolochic acid ; Toxicity ; Experimental carcinogenesis ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract After treatment for 3 weeks with aristolochic acid (AA) in daily doses of 5.0 mg/kg mice were kept under observation for approximately 1 year. During this period papillomatous changes occurred in the forestomach. At a later stage, squamous cell carcinomas were observed in all the animals. In one case, an adenocarcinoma was found in the glandular stomach. In addition, malignant lymphomas were found, as well as adenomas of the kidneys, carcinomas of the lungs, and haemangiomas of the uteri.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293699
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  • 8
    Electronic Resource
    Electronic Resource
    Renal toxicity of aristolochic acid in rats as an example of nephrotoxicity testing in routine toxicology (1993)
    Springer
    Archives of toxicology 67 (1993), S. 307-311 
    Details
    ISSN: 1432-0738
    Keywords: Aristolochic acid ; Nephrotoxicity ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The nephrotoxic action of aristolochic acid (AA) was investigated in female Wistar rats given single doses of 10, 50 or 100 mg/kg by gastric tube. Renal lesions developed within 3 days, the effect being dose-dependent. Histologically, there was evidence of necrosis of the epithelium of the renal tubules, and functionally, there were rises in plasma creatinine and urea together with increases in urinary glucose, protein, N-acetyl-β-glucosaminidase, gammaglutamyl transferase and malate dehydrogenase. Taking AA as an example, the aim of the present study was to consider the suitability of this model, based on a combination of histology and laboratory investigations, as a short-term test for the detection of nephrotoxic agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01973700
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