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  • 1
    Electronic Resource
    Electronic Resource
    Electronic and Geometrical Structure of Bicyclo[8.1.0]undec-1(10)-en-5-yn-11-one and Related Compounds (1995)
    s.l. : American Chemical Society
    The @journal of organic chemistry 60 (1995), S. 4692-4696 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo00120a008
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    [n.n]Cyclopropenyliophanes
    Amsterdam : Elsevier
    Tetrahedron Letters 33 (1992), S. 3473-3476 
    Details
    ISSN: 0040-4039
    Keywords: bis-cyclopropenes ; bis-cyclopropenylium ions ; cyclopropenyliophanes
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0040-4039(00)92666-2
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Modulation by 5-HT3 and 5-HT4 receptors of the release of 5-hydroxytryptamine from the guinea-pig small intestine (1993)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 347 (1993), S. 137-140 
    Details
    ISSN: 1432-1912
    Keywords: Enterochromaffin cells ; 5-Hydroxytryptamine release ; 5-HT3 receptors ; 5-HT4 receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of agonists and antagonists of 5-hydroxytryptamine (5-HT) receptors on the release of endogenous 5-HT from enterochromaffin cells were studied in the vascularly perfused isolated guinea-pig small intestine. The experiments were done in the presence of tetrodotoxin in order to exclude a neuronally mediated influence on 5-HT release. The 5-HT3 receptor agonist 2-methyl-5-HT increased 5-HT release, and this effect was antagonized by 1 nmol/l tropisetron. Nanomolar concentrations of tropisetron, MDL 72 222 and granisetron decreased 5-HT release. Ondansetron (0.1 and 1 μmol/1) did not modify 5-HT release. 5-Methoxytryptamine, BIMU8 and cisapride concentration-dependently inhibited 5-HT release. BIMU8 was more potent than 5-methoxytryptamine. Micromolar concentrations of tropisetron (1 and 10 μmol/1) enhanced the release, whilst methiothepine (0.1 μmol/l) did not affect the release of 5-HT. The results suggest that enterochromaffin cells of the guinea-pig ileum do not contain 5-HT1 and 5-HT2 receptors, but are endowed with 5-HT3 and 5-HT4 autoreceptors. Activation of the 5-HT3 receptors triggers a positive feedback mechanism leading to an increase of 5-HT release. The 5-HT3 receptors on the enterochromaffin cell differ from neuronal 5-HT3 receptors on guinea-pig myenteric plexus by their high affinity for tropisetron and MDL 72 222, and their very low affinity for ondansetron. Stimulation of 5-HT4 receptors causes inhibition of release; the inhibitory 5-HT4 receptor mechanism appears to predominate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169258
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    Paper (German National Licenses)
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