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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 37 (1997), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 39 (1998), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the European Academy of Dermatology and Venereology 12 (1999), S. 0 
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 270 (1981), S. 325-331 
    ISSN: 1432-069X
    Keywords: Rat preputial gland ; Sebaceous glands ; Intracellular secretion ; Sexual hormones ; Hormonal control ; Preputiale Rattendrüsen ; Talgdrüsen ; interzelluläre Sekretion ; Sexualhormone ; hormonale Kontrolle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Durchmesser, der mit Sudanschwarz B gefärbten Talgtropfen und mit saurem Hämatin gefärbten perinukleären Granula und deren zahlenmäßige Dichte wurde in reifen preputialen Talgzellen normaler und mit Testosteron behandelter weiblicher Ratten sowie mit Östradial behandelter männlicher Ratten bestimmt. Mit Hilfe einer statistischen Analyse durch den Student-Test zeigte sich, daß der Durchmesser der Fetttröpfchen bei männlichen Tieren signifikant größer war als in den weiblichen Kontrollen, und daß Testosteron die weiblichen Werte zu der von normalen männlichen Kontrollen anhoben. Östradiolbehandlung verminderte die Werte unter den normaler weiblicher und männlicher Kontrollen und Testosteron-behandelter weiblicher Ratten. Der Durchmesser der perinukleären Granula veränderte sich innerhalb der verschiedenen Tiergruppen nicht, doch war die nunmehrige Dichtheit in den mit Testosteron behandelten Tieren größer als bei den normalen weiblichen oder mit Östradiol behandelten männlichen Ratten. Die Fetttröpfchen und die Fetttröpfchengröße sowie die Zahl der perinukleären Granula werden somit durch Androgene erhöht und durch Östrogene vermindert. Dies besagt, daß Sexualhormone nicht allein auf die Multiplikation der Talgdrüsenzellen oder auf die Umwandlungszeit, wie früher bereits berichtet, einwirken, sondern auch die Produktion der Lipide und die Freisetzung der β-Glucuronidase enthaltenden Granula in diesen Drüsen beeinflussen.
    Notes: Summary The diameters of Sudan Black B stained sebum vesicles and acid hematein stained perinuclear granules, and the numerical density of the latter, were determined in mature sebaceous preputial cells from normal male and female rats, testosterone-treated female rats and estradiol-treated male rats. Statistical analysis by Student's t-test showed that the diameter of lipid droplets was significantly higher in male than in female controls and that testosterone increased female values up to male control levels. Estradiol treatment decreased male values to levels below those of normal male and female controls and of testosterone-treated female rats. Diameters of perinuclear granules did not vary among animal groups but their numerical density was larger in testosterone treated than in normal female rats or estradiol treated male rats. Lipid droplet sizes and perinuclear granule numbers are thus increased by androgens and decreased by estrogens, which was interpreted as meaning that sexual hormones do not only act on sebaceous cell multiplication or turnover time as previously known, but also on the production of lipid and the output of beta-glucuronidase containing granules in this gland.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Synopsis Four acid hydrolases in the secretory cells and the sebum of the preputial sebaceous gland of the rat were incestigated cytochemically. A strong β-glucuronidase activity was found to occur in the matrix of the perinuclear secretion granules, whereas the granule crystalloids were unreactive. The distribution of acid phosphatase at the light microscope level was similar, though the intensity of the reaction was lower and the number of positive granules smaller. By electron microscopy, the final reaction product of acid phosphatase occurred in patches at the periphery of the granule matrix, as well as in the vesicles adjoining the Golgi stacks, from which the perinuclear granules seemed to arise. In the sebum, the two hydrolases occurred in the background material between the unstained crystalloid masses. There was noN-acetyl-β-glucosaminidase or aryl sulphatase activity in the gland. The perinuclear granules appear to be secretory lysosomes which, after discharge from the disaggregating cell, release their acid hydrolases into the sebum.
    Type of Medium: Electronic Resource
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