ISSN:
1432-2072
Keywords:
Methamphetamine
;
Septal Stimulation
;
Limbic Seizures
;
Septal after-Discharge
;
Shock Avoidance
;
Cat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract It was predicted that methamphetamine administered to nine adult male cats would counteract the debilitating effects of electrically-induced septal after-discharges (seizures) upon learned shock avoidance. Performance was assessed in terms of number of avoidance responses and their latencies. Septal after-discharges of over five seconds duration resulted in the predicted deterioration of avoidance performance. Under the dosage (1.5 mg/kg) and conditions employed in the present experiment, methamphetamine appeared to enhance, rather than counteract, this effect. Methamphetamine alone had mixed effects upon avoidance behavior: there was less tendency for animals to “freeze” in response to the CS, but subjects appeared confused and disoriented. There was a greater likelihood of occurrence of after-discharges when methamphetamine was used in conjunction with electrical stimulation of the septum.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02419062
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