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  • 1
    Electronic Resource
    Electronic Resource
    Longitudinally orientated smooth muscle cells in rabbit arteries (1993)
    Springer
    Virchows Archiv 422 (1993), S. 293-299 
    Details
    ISSN: 1432-2307
    Keywords: Smooth muscle cells ; Intima ; Arteries
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intima formation in vessels, spontaneous or experimentally induced, is generally characterized by the presence of longitudinally orientated smooth muscle cells (LSMC). During an experiment of neo-intima induction in carotid arteries in rabbits, by application of a nonconstrictive silastic cuff, a study was performed to investigate the presence of LSMC in the systemic and pulmonary circulations, in both elastic and muscular arteries. Three patterns could be distinguished: intimai cushions in muscular arteries, single or small groups of LSMC in the intima in elastic and larger muscular arteries, and intra-medially located layers or columns of LSMC in the aorta, the pulmonary artery, at the bifurcation of the aorta and around orifices of branches. In order to understand this peculiar orientation a biomechanical approach was used: this showed that near the lumen the circumferential stress is 4.5 times higher than the longitudinal. Because the cell surface of the smooth muscle cells exposed to this stress per unit vessel length is much less in the longitudinal than in the circular direction we conclude that the LSMC align in the direction which allows them to cope most effectively with the mechanical stresses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01608338
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The modulation of smooth muscle cell phenotype is an early event in human aorto-coronary saphenous vein grafts (1992)
    Springer
    Virchows Archiv 420 (1992), S. 155-162 
    Details
    ISSN: 1432-2307
    Keywords: Coronary artery bypass ; Saphenous vein ; Smooth muscle cells ; Synthetic phenotype
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The morphological changes in human vein grafts occurring in the first days after a coronary bypass operation (CBP) are rarely reported in the literature. Sections of aorto-coronary vein grafts from 11 patients who died during the first 10 days after a CBP were obtained at autopsy. The number of vein grafts per patient ranged from 1 to 4, yielding a total of 28 vein grafts. The early changes in the vein grafts have been studied by light microscopy, immunohistochemistry, transmission and scanning electron microscopy. The study demonstrates that soon after grafting, the vein wall is infiltrated by polymorphonuclear leucocytes (PMN). At 24 h the endothelium shows extensive desquamation. The massive migration of PMN through the venous wall occurs simultaneously with the endothelial damage. The circular layer of the media is severely damaged, resulting in a loss of smooth muscle cells (SMC). The remaining SMC in this layer show a change toward the synthetic phenotype and a reduced expression of α-smooth muscle actin. These early changes in the SMC function may initiate the process of fibrosis in the intima and the media of the vein grafts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02358807
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Die Anfänge des Gerontoxon (1927)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 119 (1927), S. 41-59 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01870264
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Über Anilidochinone aus Benzochinon und den Nitranilinen (1918)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 416 (1918), S. 181-188 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19184160204
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    Paper (German National Licenses)
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