ISSN:
1432-1440
Keywords:
Key words Islets of Langerhans
;
Allogeneic transplantation
;
Rejection markers
;
CD44
;
Diabetes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Upon allogeneic transplantation (Tx) of pancreatic islets under the kidney capsule of diabetic rats, cells from draining lymph nodes and, to a minor degree, bone marrow transiently upregulate CD44 splice variants as detected by RT-PCR using CD44 variant exon specific primers. Maximal expression was on day 5 post Tx in lymph nodes and thus precedes islet rejection sufficiently (in this model by 5 days) to still permit establishing rescue by immunosuppressive therapy. CD44 variant exon sequence could therefore serve as early markers of allograft rejection.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s001090050303
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