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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 28 (1972), S. 1160-1161 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Le pentobarbital provoque un accroissement important de l'activité de la phosphoprotein-phosphatase extramicrosomiale du foie du rat. L'accroissement de l'activité de l'enzyme se produit dejà 20 min après l'administration du médicament (+40%) et dure autant que le traitement (+50–70%). Le niveau de l'induction dépend de la dose du pentobarbital. L'induction est bloquée par l'administration simultanée du cycloheximide ou du SKF 525-A.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 27 (1971), S. 1477-1478 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé On a constaté que l'arginase des reins est plus sensible que l'arginase du foie a l'hydrocortisone injecté. Au contraire, l'adrénalectomie provoque la réduction de l'activité arginasique du foie mais ne modifie pas le niveau de l'arginase rénale.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Research in experimental medicine 157 (1972), S. 317-324 
    ISSN: 1433-8580
    Keywords: Arginase ; Liver Regeneration ; Cell Multiplication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An increase of arginase activity was found in the liver 6 and 12 hrs after partial hepatectomy in saline-treated (11.9 and 20.3%, respectively) and in phenobarbital-treated animals (16.3 and 61.8%, respectively). In both groups the increase of arginase activity was achieved only after the removal of a “threshold” amount of liver tissue. For saline-treated rats the “threshold” amount was two thirds hepatectomy and in phenobarbital treated rats 34% hepatectomy. In both groups of animals the maximal response was obtained at two thirds hepatectomy, which at the same time provokes the maximal proliferative activation of the liver cells. The existence of a positive correlation between the degree of increase of arginase activity during the first hours after partial hepatectomy and the degree of DNA synthesis and mitotic activiation of liver tissue, which followed 12 hrs later, excludes the arginase as a factor which inhibits cells multiplication during the regenerative growth of the liver.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 25 (1969), S. 478-479 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé On a constaté qu'une injection du phénobarbital provoque la diminution de la concentration du glycogène libre de 34% et la diminution du glycogène total de 22,6% seulement 24 h après leur injection. La répétition des injections du phénobarbital diminue le glycogène libre respectivement de 36% et de 28%, le glycogène lié de 46% et de 27%, et le glycogène total de 41% et 24%.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1438-2199
    Keywords: Amino acids ; Glutathione ; Glutathione reductase ; Glutathione S-transferase ; Chronic renal insufficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Reduced glutathione (GSH) levels and glutathione reductase (GR) and glutathione S-transferase (GST) activities were investigated in the erythrocytes and lymphocytes of non-dialyzed patients with varying degrees of chronic renal insufficiency, and also of patients on regular hemodialysis treatment. GSH, GR and GST levels were higher in erythrocytes and lymphocytes of examined patients as compared to their corresponding age-matched healthy controls. A correlation was found between the degree of renal insufficiency and the above parameters tested. A routine hemodialysis did not significantly affect erythrocyte and lymphocyte GSH content and activities of its associated enzymes. The increased GSH levels as well as GSH-linked enzyme activities of blood cells in uremia may be a protective mechanism for the cells due to the accumulation of toxic, oxidizing, wastes in the blood as a result of the uremic state. This view is supported by the results ofin vitro experiments, which have shown that GR and GST activities of normal human lymphocytes are increased when incubated with plasma from uremic patients.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-2277
    Keywords: Key words Renal transplantation ; Oxidative stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An increased degree of oxidative stress (OS) in chronic renal failure (CRF) and a possible role of free radicals in CRF have already been described. However, data on OS after renal transplantation are scarce. The aim of the present study was to estimate the degree of OS in renal transplant patients. The study included four groups: 1) 15 haemodialysis patients (HD group), 2) 11 renal transplant patients with stable function (SF group), 3) 12 renal transplant patients with chronic biopsy-proven rejection (CR group), and 4) 10 healthy controls (C group). Markers of OS (malondialdehyde and thiol group levels) and antioxidant activity (glutathione peroxidase and Cu,Zn-superoxide dismutase) were determined in plasma and in red blood cells of all examined individuals. After successful renal transplantation a significant improvement, but not normalization, of antioxidant enzyme activities accompanied by significantly reduced lipid peroxidation were found. In the CR group the degree of OS was increased, and our results suggest that OS may be a relevant pathophysiological factor for CR development.
    Type of Medium: Electronic Resource
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