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  • 1
    Electronic Resource
    Electronic Resource
    An evaluation of motor function in transverse colon transplants after total gastrectomy (1998)
    Springer
    Surgery today 28 (1998), S. 10-17 
    Details
    ISSN: 1436-2813
    Keywords: colon motility ; transverse colon transplant ; total gastrectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The motor activity of the isolated colon is under-stood less than that of any other part of the gastrointestinal viscus. Thus, the aim of the present study was to evaluate the motor activity of the interposed transverse colon following total gastrectomy through a study of 21 patients. Manometric studies were carried out with a 5-lumen, open-tipped catheter in the resting state, in response to dry swallows, and swallowing distilled water and a liquid meal. Contractile waves in the interposed colon grafts were divided into three types, namely, high-amplitude propagated contractions (HAPCs), low-amplitude propagated contractions (LAPCs), and low-amplitude nonpropagated contractions (LANPCs). No retrograde contractions were observed during the entire recording. Motor activity in the interposed colon increased to a greater extent after swallowing distilled water or liquid meals than during the resting period or after dry swallows; however, there was no significant difference between the effect of distilled water and liquid meals. The motor activity of the interposed colon was lower in patients with symptoms than in asymptomatic patients. These results suggest that the volume, rather than the composition, of the lumen contents is an important factor for inducing interposed colon graft contractions, and that contractions of the interposed colon can help to propel the contents of the colon into the duodenum and clear any duodenal juice if reflux should occur.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02483602
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    An Evaluation of Motor Function in Transverse Colon Transplants After Total Gastrectomy (1998)
    Springer
    Surgery today 28 (1998), S. 10-17 
    Details
    ISSN: 1436-2813
    Keywords: Key Words: colon motility ; transverse colon transplant ; total gastrectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005950050070
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Mechanism of inhibitory effect of glucagon on gastrointestinal motility and cause of side effects of glucagon (1998)
    Springer
    Journal of gastroenterology 33 (1998), S. 835-841 
    Details
    ISSN: 1435-5922
    Keywords: Key words: glucagon ; motility ; side effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Glucagon is commonly used during gastrointestinal examinations for the temporary inhibition of gastroduodenal movements. Three preparations of glucagon are now clinically available: those prepared by extraction from the pancreas (GL-P), by chemical synthesis (GL-S), and by genetic recombination (GL-G). The aim of this study was examine the mechanism of the inhibitory effect of glucagon on gastrointestinal motility and the cause of its side effects by comparing three glucagon preparations. In four conscious dogs, gastrointestinal contractions were monitored by means of chronically implanted force transducers. Each glucagon preparation (GL-P [15 μg/kg], GL-S [5, 15, 45 μg/kg], GL-G [15 μg/kg]), scopolamine butylbromide (0.4 mg/kg), or saline was administered intravenously 20 min after the termination of spontaneous phase III contractions, and blood samples were taken at 5- to 10-min intervals. Barium was administered into the stomach 10 min after the infusion of each drug. The arrival of a barium meal in the stomach immediately stimulated gastrointestinal contractions, and the barium meal was expelled into the duodenum and jejunum from the stomach. Intravenous injection of 15 μg GL-S first stimulated duodenal contractions that propagated to the jejunum, followed by strong inhibition of the barium-induced gastrointestinal contractions. This inhibitory effect of glucagon and the activity of the glucagon-induced duodenal contractions were dose-related. The inhibitory effects of GL-G and GL-S were stronger than that of GL-P. Blood glucose and plasma insulin concentrations were raised after intravenous injection of each glucagon preparation, but there was no difference among the three preparations and no dose relationship. The inhibitory effects of glucagon depend on the material purity and dose, and the inhibitory mechanism was independent of any effect on carbohydrate metabolism. Glucagon administration caused phase III-like contractions in the duodenum and jejunum, which may be responsible for the side effects of glucagon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005350050184
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of EM574 on Postprandial Pancreaticobiliary Secretion, Gastric Motor Activity, and Emptying in Conscious Dogs (1999)
    Springer
    Digestive diseases and sciences 44 (1999), S. 1100-1106 
    Details
    ISSN: 1573-2568
    Keywords: ERYTHROMYCIN DERIVATIVE ; POSTPRANDIAL PANCREATICOBILIARYSECRETION ; AMYLASE OUTPUT ; BILE ACID OUTPUT ; FORCE TRANSDUCER ; GASTRIC ANTRAL MOTILITY ; FREEZE-DRYING METHOD ; GASTRIC EMPTYING
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract EM574, an erythromycin derivative and a potentmotilin receptor agonist, is now under clinical trial asa gastroprokinetic drug. The aim of this study was toestimate the effect of EM574 on postprandial pancreaticobiliary secretion, gastric motoractivity, and emptying in conscious dogs. Five mongreldogs were prepared. Indwelling cannulas for bothinfusion of phenolsulfonphthalein and aspiration ofluminal samples were inserted into the proximal anddistal duodenum, respectively. EM574 (3-30 μg/kg) wasgiven intraduodenally through the indwelling distalduodenal cannula at the start of feeding. Postprandial pancreatic and biliary secretions were assessedby measuring the outputs of amylase and bile acid intothe duodenum, respectively. Gastric motor and emptyingactivity were measured by means of a force transducer method and our own freeze-drying method,respectively. One hundred grams of a freeze-driedstandard meal was given as a solid marker after beingmixed with 100 ml of normal saline containing 15 g ofpolyethylene glycol as a liquid marker. EM574 at doses of 10and 30 μg/kg significantly increased the meanintegrated postprandial amylase output into theduodenum, but the mean integrated postprandial bile acidoutput was not significantly increased. EM574increased postprandial gastric antral motor activitydosedependently. EM574 at doses of 10 and 30 μg/kgsignificantly accelerated gastric emptying of liquidsand solids, respectively. EM574 enhances gastricantral motor activity and accelerates gastric emptyingof solids and liquids with a concomitant increase inpostprandial pancreatic amylase, but not bile acid, output in normal dogs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026655619282
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Postprandial Normal Saline Intake Delays Gastric Emptying of Solids in Conscious Dogs (Partial Involvement of CCK in Its Mechanism) (1999)
    Springer
    Digestive diseases and sciences 44 (1999), S. 1516-1524 
    Details
    ISSN: 1573-2568
    Keywords: FREEZE-DRYING METHOD ; FORCE TRANSDUCER ; POSTPRANDIAL AMYLASE OUTPUT ; POSTPRANDIAL ; BILE ACID OUTPUT ; CCK ANTAGONIST
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although it is known that a caloric liquid mealgiven after food intake delays solid gastric emptying,the effect of a noncaloric liquid is not known. The aimsof this study were to determine the effect of normal saline given at 3 hr after feeding ongastric antral motor activity and gastric emptying andto evaluate the role of endogenous cholecystokinin inthe changes in gastric function induced by postprandial saline intake in conscious dogs. Two cannulaswere implanted in each of five mongrel dogs for infusionof phenolsulfonphthalein into the proximal duodenum andfor aspiration of luminal samples from the distal duodenum. Gastric contractile andemptying activity were measured by the force transducermethod and a freeze-drying method newly developed by ourgroup, respectively. Postprandial pancreaticobiliary secretion was assessed from amylase and bileacid outputs into the duodenum. One hundred grams offreeze-dried dog food was given as a solid meal aftermixing it with 100 ml of normal saline. The dogs were given 100 ml of normal saline per os at 3 hrafter feeding. In another study, intravenousadministration of devazepide, a specificcholecystokinin-A receptor antagonist, at a dose of 0.1mg/kg/hr was begun 15 min before postprandial saline intake andcontinued for 1 hr. Gastric antral motility wassignificantly (P 〈 0.01) inhibited for 30 min afterthe dogs had drunk saline at 3 hr after feeding. Themean fractional emptying rate of gastric solids inpercentage per 30 min after postprandial saline intakewas significantly (P 〈 0.05) slower than that in thecontrol study without saline intake at 3 hr after feeding. Amylase output into the duodenum afterpostprandial saline intake showed a gradual increaselasting for about 1 hr, whereas that of bile acidincreased transiently but markedly 15 min after saline intake, in comparison with the control study.Pretreatment with devazepide partially ameliorated thesuppression of gastric antral motility. Postprandialintake of saline inhibited gastric motor activity and delayed solid gastric emptying, whereas itincreased the outputs of amylase and bile acid.Endogenous cholecystokinin may be partially involved inthese phenomena caused by saline intake at 3 hr after feeding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026642422375
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