ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Nitric oxide (NO) produced in the endothelial cells and other tissues has been known toplay a range of physiological roles including vasodilation. Thus, direct in vivo measurement of NO isof great importance for clarification of physiological roles of NO and development of therapeuticsusing NO. It has long been assumed that NO is readily oxidized in blood and cannot be detected;however, some recent reports demonstrated much longer half-life of NO in the blood stream in vivo.Recently, we reported the basic performance of an NO sensor which is applicable to in vivomeasurement. This sensor can detect NO in the blood stream in an anesthetized rat and somebiological samples including a dialysis solution. In these studies we found that NO itself showeddynamic changes different from these of oxidative products of NO (nitrite and nitrate) that areconventionally used as indices of NO level. We have also developed a catheter-type NO sensor anddemonstrated validity of the sensor for in vivo measurement of NO in the aorta and coronary sinus ofanesthetized dogs and rabbits. Both endothelium-dependent and -independent NO productions couldbe detected. In conclusion, the NO sensor and the catheter-type NO sensor are applicable to directmeasurement of NO in biological samples even in vivo and will contribute to clarification ofphysiological roles of NO
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/57/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.381-382.343.pdf
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