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  • 1
    Electronic Resource
    Electronic Resource
    Relationship between plasma concentration and arousal in normal subjects after single oral and parenteral doses of melperone, a butyrophenone neuroleptic (1983)
    Springer
    Psychopharmacology 79 (1983), S. 111-114 
    Details
    ISSN: 1432-2072
    Keywords: Melperone ; CFFF ; Plasma concentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relationship between plasma concentration and effect on arousal was studied in normal subjects after single oral and parenteral doses of melperone. A strong correlation between plasma concentration and effect was found when the effector compartment and central compartment were in equilibrium. The relationship was independent of the route of administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427795
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Sedative effects and prolactin response to single oral doses of melperone (1983)
    Springer
    Psychopharmacology 79 (1983), S. 142-147 
    Details
    ISSN: 1432-2072
    Keywords: Prolactin ; CFFF ; Arousal ; Pharmaco-kinetics ; Melperone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The pharmacokinetics of melperone and the relationship between plasma concentration and the effect on arousal and prolactin secretion after single oral doses (10, 25, 50 and 100 mg) was studied in normal subjects. Dose-dependent kinetics were indicated by the fact that higher plasma concentrations than expected were demonstrated after the 100-mg dose. Melperone decreased arousal and increased prolactin secretion in a dose-dependent manner. The level of arousal was correlated to melperone plasma concentration over the entire dose range. Prolactin secretion was also correlated to melperone plasma concentration, provided the relationship was studied separately for the individual melperone doses. Thus at higher doses, higher plasma concentrations are needed to elicit the same prolactin outflow. The possibility that reduced arousal reactions might contribute in the antipsychotic action of neuroleptic drugs was discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427801
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of melperone, chlorpromazine, haloperidol, and diazepam on experimental anxiety in normal subjects (1982)
    Springer
    Psychopharmacology 77 (1982), S. 109-113 
    Details
    ISSN: 1432-2072
    Keywords: Classical conditioning ; Experimental anxiety ; Neuroleptics ; Anxiolytics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An attempt was made to evaluate tranquilizing effects of three neuroleptic drugs (10 and 50 mg melperone, 1 mg haloperidol, and 50 mg chlorpromazine) and diazepam (10 mg) on experimental anxiety in normal subjects. This was done by studying the effect of the drugs on the anticipatory autonomic (skin conductance) response evoked during aversive classical conditioning. Diazepam, 50 mg melperone, and chlorpromazine completely abolished the anticipatory response, decreased the number of conditioned and unconditioned responses, and decreased skin conductance level. Treatment with 10 mg melperone and haloperidol had no effect on the conditioned and unconditioned responses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431930
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of single oral doses of various neuroleptic drugs on salivary secretion rate, pH, and buffer capacity in healthy subjects (1981)
    Springer
    Psychopharmacology 75 (1981), S. 114-118 
    Details
    ISSN: 1432-2072
    Keywords: Neuroleptics ; Salivary secretion rate ; Salivary pH ; Salivary buffer capacity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of melperone, thioridazine, levomepromazine, and chlorprotixene on salivary secretion rate, pH, and buffer capacity was studied in eight healthy volunteers given single oral doses of placebo or 10, 25, and 50 mg of the drugs in a single-blind crossover design. Both resting and stimulated saliva samples were collected before and every hour for 6 h after administration. All drugs reduced secretion rate and lowered pH and buffer capacity, mostly in a dose-dependent manner. The effects of levomepromazine and chlorprotixene were more pronounced than those of melperone and thioridazine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432171
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Electroencephalographic effects of intravenous nicotine – a dose-response study (1999)
    Springer
    Psychopharmacology 145 (1999), S. 342-350 
    Details
    ISSN: 1432-2072
    Keywords: Key words EEG ; P300 ; Intravenous ; Nicotine ; Dose-response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Rationale: It has often been demonstrated that both tobacco abstinence and nicotine have effects on the EEG power spectrum and components of the event-related potentials. In contrast, few attempts have been made to establish the dose-response relationship between nicotine and EEG parameters. Objectives: The aim of this study was to investigate the dose-response relationship for EEG and auditory oddball P300 parameters over a wide range of intravenously infused nicotine doses. Method: Fourteen regular smokers who had abstained from nicotine for at least 12 h were given intravenous infusions of 0, 3.5, 7, 14 and 28 µg/kg nicotine over 10 min in a single-blind randomised cross-over design. Parallel recordings of spontaneous EEG, auditory P300 and heart rate, as well as venous blood sampling were made before, during and after nicotine administration. Results: Linear dose-related decreases of delta and theta power were found, along with increases in alpha2 power and alpha peak frequency. Alpha1, beta and P300 parameters were unaffected. Conclusion: Our results are consistent with nicotine-dependent changes in EEG measures indicative of arousal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130051067
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of thymoleptics on behaviour associated with changes in brain dopamine (1976)
    Springer
    Psychopharmacology 45 (1976), S. 261-265 
    Details
    ISSN: 1432-2072
    Keywords: Thymoleptics ; Gnawing ; Mice ; Dopa ; Dopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The thymoleptics imipramine, desipramine, protriptyline, nortriptyline, chlorimipramine and amitriptyline all potentiate gnawing of mice induced by Dopa following the decarboxylase inhibitor Ro 4-4602. The gnawing behaviour is probably associated with the increase in brain dopamine resulting from this treatment. Thymoleptics also affect other types of behaviour associated with brain dopamine. The relevance of these effects to clinical antidepressive effect and their possible utilization for preclinical screening tests is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421137
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    An explanation of the apparently increased incidence of moderate mental retardation in Turner's syndrome (1973)
    Springer
    Behavior genetics 3 (1973), S. 37-43 
    Details
    ISSN: 1573-3297
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract The distributions of scores achieved by 44 persons with Turner's syndrome on two tests of intelligence are analyzed. Bimodal trends in these distributions are attributed to the effect on the Full Scale IQ of lower scores on specific, nonverbal subtests. Therefore, the diagnosis of Turner's syndrome does not imply an increased risk of a general if moderate intellectual retardation but does indicate a need for careful evaluation of the range of abilities in affected persons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01067687
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    Paper (German National Licenses)
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