ISSN:
1432-2072
Keywords:
β-Carbolines
;
FG 7142
;
Benzodiazepines
;
Diazepam
;
Ro 15-1788
;
Drug dependence
;
Cat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The β-carbolines, which are potent ligands for benzodiazepine receptors, antagonize the pharmacological actions of benzodiazepines. In the cat, the stable β-carboline derivative methylamide-β-carboline-3-carboxylate, FG 7142, and the specific benzodiazepine antagonist Ro 15-1788 reversed behavioral and electroencephalographic (EEG) changes produced by a single dose of diazepam. Surprisingly, the β-carboline did not elicit signs of withdrawal when given after 22 days of a daily dose regimen of diazepam, while Ro 15-1788 precipitated an acute abstinence syndrome largely characterized by tremors, increased muscle tone, back arching, myoclonic jerks and pupil dilatation. Unlike Ro 15-1788, the β-carboline produced effects of its own such as behavioral states of arousal and fearfulness. These findings indicate that the β-carboline functionally interacts with benzodiazepine receptors in a manner unlike that seen with typical agonists and antagonists.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00431697
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