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  • 1
    Electronic Resource
    Electronic Resource
    Salivary gland tumours studied by means of the AgNOR technique (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 13 (1988), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Difficulty is sometimes encountered in distinguishing between pleomorphic adenoma, adenoid cystic carcinoma and adenocarcinoma, especially in small biopsies from salivary glands. The argyrophil (AgNOR) staining technique for nucleolar organizer regions (NORs) has been applied to a series of benign and malignant salivary gland tumours. We studied 35 salivary gland tumours, 13 benign and 22 malignant. In all specimens clearly defined silver-stained intranuclear AgNOR dots were visible. The differences between the numbers of AgNORs in the benign and malignant groups, notably pleomorphic adenomas, adenoid cystic carcinoma and adenocarcinoma, were highly significant. In view of this difference we propose that the AgNOR staining technique is of diagnostic help in distinguishing between these salivary gland tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1988.tb02079.x
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  • 2
    Electronic Resource
    Electronic Resource
    ABT-491, a highly potent and selective PAF antagonist, inhibits nasal vascular permeability associated with experimental allergic rhinitis in Brown Norway rats (1997)
    Springer
    Inflammation research 46 (1997), S. 133-134 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050141
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  • 3
    Electronic Resource
    Electronic Resource
    Ex vivo inhibition of β-thromboglobulin release following administration to man of ABT-299, a novel prodrug of a potent platelet activating factor antagonist (1997)
    Springer
    Inflammation research 46 (1997), S. 272-277 
    Details
    ISSN: 1420-908X
    Keywords: Key words: ABT-299 — Platelet activating factor (PAF) —β-thromboglobulin — Platelet — Degranulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: ABT-299 is a prodrug that is converted by serum esterase to a potent platelet activating factor (PAF) antagonist (A-85783). In order to evaluate the pharmacological activity of this antagonist in man the effect of ABT-299 given to healthy volunteers on ex vivo PAF-induced β-thromboglobulin (β-TG) release in blood was assessed.¶Subjects: 37 healthy male volunteers, age 18 to 40 (mean age of 23.6 years) and free of medication, participated in the study.¶Treatment: Subjects were administered intravenously 0.8 mg, 2 mg, or 70 mg doses of ABT-299 (6–7 subjects per group) or placebo (9 subjects, pooled).¶Methods: Peripheral blood taken over 12 h after dosing was used for ex vivo β-TG release and, in the case of the 70 mg dose, measurement of plasma drug concentration. Data were compared by Student's t-test.¶Results: All three doses produced highly significant inhibition (p 〈0.005 compared to predose values) of PAF-induced β-TG release (units/ml plasma±SEM) 12 h after drug administration (54±14 vs. 405±51, n=8; 79±23 vs. 480±127, n=7; 21±10 vs. 327±72, n=6, respectively) whereas there was no significant difference in β-TG release in the placebo group (449±90 vs. 307±49, n=9). Inhibition was associated with the rapid appearance in plasma of A-85783 and the pyridine N-oxide metabolite of A-85783. Within 2 h, the plasma concentration of the metabolite exceeded that of the parent drug. Both the parent drug and the metabolite exhibited potent in vitro inhibition of PAF-induced β-TG release (A2 values of 4 and 1 nM respectively).¶Conclusions: These studies are the first to illustrate the utility of the β-TG release assay for assessing ex vivo activity of PAF antagonists. These studies also demonstrate that the administration of ABT-299 to man results in potent, long lasting inhibition of PAF-mediated platelet activation, due in part to the pyridine-N-oxide metabolite, and support the potential therapeutic utility of this prodrug in treating PAF-mediated diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050186
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  • 4
    Electronic Resource
    Electronic Resource
    Eicosanoid production and phospholipase A2 secretion by peritoneal macrophages from rats with adjuvant-induced arthritis (1991)
    Springer
    Inflammation research 34 (1991), S. 81-83 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of adjuvant-induced arthritis on rat peritoneal macrophage (RPM) function with respect to [14C]arachidonic acid (AA) release, leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) production, and secreted phospholipase A2 (PLA2) activity was investigated. Twice as many cells were lavaged from the peritoneal cavity of arthritic rats 21 days post-adjuvant injection than were lavaged from normal rats. PGE2 production was increased two-fold in Ca++ ionophore-stimulated RPM from the adjuvant animals as compared with RPM from control animals. However, PLA2 secretion, LTB4 production and [14C]AA release were unchanged. These results suggest that PGE2 production, rather than LTB4 production or PLA2 secretion, is preferentially enhanced in Ca++ ionophore-stimulated RPM from arthritic rats and may, therefore, reflect a major role for PGE2 in adjuvant-induced arthritis. However, the presence of increase numbers of macrophages and their associated products, including PLA2 and LTB4, may also contribute to the inflammatory process in this disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01993244
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  • 5
    Electronic Resource
    Electronic Resource
    Expression, release, and regulation of human TNFα from stable transfectants of HEK-293 cells (1997)
    Springer
    Inflammation research 46 (1997), S. 127-128 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050138
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  • 6
    Electronic Resource
    Electronic Resource
    Experience with the home-care of tracheotomised paediatric patients (1989)
    Springer
    European archives of oto-rhino-laryngology and head & neck 246 (1989), S. 345-348 
    Details
    ISSN: 1434-4726
    Keywords: Paediatric tracheotomy ; Home-care
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Many infants with tracheotomies remain cannulated for prolonged periods while the underlying cause of airway obstruction is either treated or natural resolution is awaited (usually by growth). To enable these children to enjoy a relatively normal family environment despite a tracheotomy, it is desirable that they should be managed at home for at least part of the time. For the past 8 years we have routinely used soft polyvinyl chloride paediatric tracheotomy tubes (Shiley) in our patients. These tubes have proved to be relatively resistant to obstruction with secretions and are changed at 1- to 2-week intervals. They can be modified by making a series of three to four 2-mm through-and-through fenestrations around the shoulder in order to improve speech production and facilitate decannulation. Parents are tutored in tracheotomy care, which includes tube changing, humidification and suction. They are then permitted to take their child home from hospital when they are considered to be competent. Twenty-eight children (13 boys, 15 girls) with a mean age of 14.5 weeks (range 1–525 weeks) at the time of tracheotomy have been managed at home using this system. The median period of hospitalisation was 12 weeks (range 5–75 weeks), and the median duration of home management was 94 weeks (range 13–394 weeks). Sixteen patients have been successfully decannulated, 11 remain cannulated and 1 died at home from sudden infant death syndrome. Despite supportive measures, the majority of the children developed intermittent chest infections. Acute tubal obstruction occurred in 9 cases and the tube displacement occurred in 3 cases; each of these episodes was treated satisfactorily by promptly changing the tube. Our overall experiences have shown that using the system described has resulted in the home-care of our patients being a safe and practical alternative to prolonged hospitalisation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00463591
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  • 7
    Electronic Resource
    Electronic Resource
    Short-term changes in 10-km race pace aerobic demand and gait mechanics following a bout of high-intensity distance running (1996)
    Springer
    European journal of applied physiology 73 (1996), S. 267-272 
    Details
    ISSN: 1439-6327
    Keywords: Oxygen uptake ; Distance running ; Gait ; Fatigue ; Aerobic demand
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Following treadmill accommodation and a 3-day period of tapered running, ten well-trained male distance runners [ $$\bar x$$ maximum oxygen uptake ( $$\dot VO_{2max} $$ ) = 71.3 ml · kg−1 · min−1] performed two 10-min level treadmill runs designed to assess running economy at 90% $$\dot VO_{2max} $$ . Video recordings were obtained during the last minute of each run to quantify selected gait descriptors. Two to 3 days following the second economy run, each subject completed 30 min of high-intensity (HI) running at 90% $$\dot VO_{2max} $$ . One, 2, and 4 days after the HI run, subjects repeated the 10-min economy runs. Compared to pre HI-run values, no significant change (P 〉 0.05) in running economy was observed during the post-HI runs. Biomechanical analyses also revealed that running style remained unaltered after the HI run. These results support earlier findings obtained on moderately trained subjects featuring measurement of running economy and gait mechanics at less-demanding intensities and suggest that among well-trained athletes, 30 min of HI running does not elicit an increase in $$\dot VO_2 $$ or disrupt gait mechanics over the short term in subsequent distance runs performed at near-maximal speeds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02425486
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