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  • 1
    Electronic Resource
    Electronic Resource
    Lymphocytoma cutis involving the lower lip (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 36 (1997), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1997.tb00408.x
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  • 2
    Electronic Resource
    Electronic Resource
    Amperometric determination of sulfur in plutonium sulfide and plutonium-uranium sulfide ceramic fuels (1968)
    s.l. : American Chemical Society
    Analytical chemistry 40 (1968), S. 217-218 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60257a048
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Reaction of Carbon with Steam at Elevated Temperatures (1953)
    s.l. : American Chemical Society
    Industrial & engineering chemistry 45 (1953), S. 677-680 
    Details
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ie50519a054
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Expression of apoptotic signaling proteins in leukoplakia and oral lichen planus: quantitative and topographical studies (2000)
    Copenhagen : Munksgaard International Publishers
    Journal of oral pathology & medicine 29 (2000), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Although the pathogenesis of leukoplakia has been unclear, carcinogenic transformation is postulated to result from alterations of apoptotic signal transduction proteins in epithelial cells. The pathogenesis of oral lichen planus (OLP) has also been unclear, but apoptotic changes of the epithelial cells in OLP have been reported. In the present study, we used a histochemical approach to describe human keratinocyte-expression of several apoptotic signaling proteins in leukoplakia, in OLP, and in normal oral mucosa as a control. Mucosal biopsies from patients with leukoplakia (n=13), OLP (n=10), and normal oral mucosa (n=9) were frozen, sectioned and immunostained with monoclonal antibodies to wild-type (wt) tumor suppressive protein p53, cyclin-dependent kinase inhibitor p21WAF1/CIP1 and the oncoproteins MDM2, and Bcl-2. Apoptosis was assessed in all cases by the TUNEL method. MDM2 and Bcl-2 expression in keratinocytes were quantitatively greater in leukoplakia than in OLP. Wt-p53 and p21WAF1/CIP1 expression was quantitatively greater in keratinocytes in OLP than in leukoplakia. Keratinocyte maturation appeared histologically normal in OLP, even though wt-p53 and p21WAF1/CIP1 were expressed in these cells. Altered keratinocyte maturation was seen in leukoplakia lesions expressing MDM2 and Bcl-2. No significant difference for the number of apoptotic epithelial cells was observed between leukoplakia and OLP, in spite of the divergent outcomes of the apoptotic signaling proteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0714.2000.290804.x
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  • 5
    Electronic Resource
    Electronic Resource
    Anti-cytoplasmic autoantibodies reactive with epithelial cells of the salivary gland in sera from patients with Sjögren's syndrome: their disease- and organ-specificities (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 28 (1999), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To test whether the autoantibodies reactive with epithelial cells of the salivary gland in sera from Sjögren's syndrome (SS) patients are specific for the organ and the disease, tissue reactivities of serum IgG obtained from the patients with SS and oral lichen planus (OLP), another immune-mediated oral mucosal disease, were examined by immunohistochemistry and Western blotting. IgG purified from the sera of SS patients specifically localized not only on the nuclei but also on the cytoplasm of the salivary gland epithelial cells. On the other hand, no convincing staining of the epithelial cells was observed when IgG purified from the sera of OLP patients or those from healthy controls were used for immunohistochemistry. No cytoplasmic staining was observed when sections of kidneys and pancreas were stained with SS patients’IgG. In Western blotting performed by using lysates of a submandibular gland as antigens, all the IgG prepared from the SS patients reacted prominently with several protein bands, including those specific for the disease and the organ. These results suggest that production of autoantibodies reacting with the cytoplasm of salivary gland epithelial cells is a characteristic of SS, and may play a role in the pathogenesis of the sialadenitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1999.tb01989.x
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  • 6
    Electronic Resource
    Electronic Resource
    Electron-microscopic histochemistry of cholinesterases in the rat brain (1964)
    Springer
    Histochemistry and cell biology 4 (1964), S. 65-72 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We modified the histochemical method of cholinesterases at electron microscope level of Barrnett and studied the fine structural localization of these enzymes in the striatum, locus coeruleus and hypothalamus of the rat brain. Important results obtained are summarized as follows: 1. The perfusion fixation of the brain with barbital acetate buffered formolsucrose-calcium followed by cutting into thin sections by the automicrochopper proved important to obtain the constant and uniform results in the histochemical demonstration of AChE at electron microscope level. However, inhibition studies of eserine and DFP upon thiolacetic hydrolysis appeared rather insufficient to exactly differentiate AChE from ChE. 2. AChE in the perikaryon of the nerve cells in the observed regions was demonstrated not only on the endoplasmic reticulum but also within the large vacuoles related to the Golgi apparatus. This finding was especially marked in the locus coeruleus. 3. The synaptic area especially in the striatum (marked cholinergic) showed 2 types of axo-dendritic synapses. The one exhibited the rather clear axoplasm with a few granular deposits and the apposed synaptic membranes, on which a moderate amount of granular deposits was demonstrated. The other type had rather dense axon terminals with contacting dendritic branches, both of which showed moderate numbers of reaction deposits. 4. In the hypothalamus, regarded as non-cholinergic or adrenergic, some axon terminals revealed small number of black deposits due to AChE in addition to the synaptic vesicles and catecholamine-containing granules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304180
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  • 7
    Electronic Resource
    Electronic Resource
    Some observations on the fine structure of the corpus striatum of the rat brain (1966)
    Springer
    Cell & tissue research 70 (1966), S. 461-488 
    Details
    ISSN: 1432-0878
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The rat corpus striatum was perfused vitally with glutaraldehyde, immersed in OsO4 and then observed under an electron microscope. Numerous small cells in the neostriatum show a simple cytoplasmic structure, while the large cells possess a complicated fine structure. These are differentiated under the elctron microscope into two kinds, which seem to have functional differences. The large pallidal cells containing much pale cytoplasm are covered with many varied axonal boutons from the cell body to the dendritic terminal making numerous axo-somatic or axo-dendritic trunk synapses. Numerous axo-dendritic, or spine synapses are recognized in the neostriatal neuropil. These numerous axon terminals, which belong to striatal nerve cells or other nuclei of the brain, are classified morphologically into several types. At least five types of synaptic vesicles are distinguished by their size or by the presence of fine dense granules on their membranes, and seem to be specific to the neostriatum. Many myelin interruptions and several kinds of glial cells in the corpus striatum are observed. Moreover, the ventricular wall of the caudate nucleus, namely, the ependyma, and two kinds of subependymal cells are described and discussed with reference to the subependymal layer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335355
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