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  • 1
    Electronic Resource
    Electronic Resource
    Expression of transforming growth factor-α in the normal cervix and in benign and malignant lesions of the uterine cervix (1994)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 101 (1994), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To investigate the expression and distribution of transforming growth factor-α (TGF-α) in the normal cervix and in benign and malignant lesions of the uterine cervix.Subjects and methods Immuno-histochemical reactivity with a monoclonal antibody against TGF-α was examined in tissue specimens from 15 normal cervices, six cervical polyps, four cervical condylomata acuminata, 34 cervical intra-epithelial neoplasias, 35 invasive squamous cell carcinomas, five adenocarcinomas, and three mixed adenosquamous carcinomas.Results Normal squamous cells of the exocervix were found to be negative for TGF-α immuno-reactivity, whereas reserve cells and metaplastic squamous cells in the transformation zone were positive for TGF-α. Although TGF-α immuno-reactivity was variable in the cervical condylomas, most cases of cervical intra-epithelial neoplasia with or without koilocytotic atypia were negative for TGF-α. In the invasive carcinomas, however, TGF-α immunoreactivity was observed in 17 out of the 35 cases of squamous carcinoma, and in all cases of adeno- and adenosquamous carcinomas. In addition, intense TGF-α immuno-reactivity was found in clinically advanced tumours.Conclusion These results suggest that the expression of TGF-α is associated with squamous metaplasia in the normal cervix, and that TGF-α may play an important role in cervical carcinogenesis, especially in its progression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1994.tb13619.x
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  • 2
    Electronic Resource
    Electronic Resource
    Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans (1997)
    [s.l.] : Nature Publishing Group
    Nature medicine 3 (1997), S. 1029-1033 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Leptin is a circulating hormone that is expressed abundantly and specifically in the adipose tissue1–5. It is involved in the regulation of energy homeostasis, as well as the neuroendocrine and reproductive systems6–11. Here, we demonstrate production of leptin by nonadipose tissue, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm0997-1029
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  • 3
    Electronic Resource
    Electronic Resource
    Immunohistochemical localization of c-erbB-2 protein and epidermal growth factor receptor in normal surface epithelium, surface inclusion cysts, and common epithelial tumours of the ovary (1992)
    Springer
    Virchows Archiv 421 (1992), S. 393-400 
    Details
    ISSN: 1432-2307
    Keywords: c-erbB-2 protein ; Epidermal growth factor receptor ; Ovarian tumour ; Oncogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The c-erbB-2 (HER-2/neu) protein is a membrane glycoprotein growth factor receptor showing molecular homology with the epidermal growth factor receptor (EGFR). We examined the immunohistochemical reactivity of monoclonal antibodies against both of these proteins in normal surface epithelium, surface inclusion cysts, and common epithelial tumours of the ovary. The ovarian tumours were classified as benign (16), borderline malignant (2), and malignant (19). Normal surface ovarian epithelium was weakly positve for both c-erbB-2 protein and EGFR. In surface inclusion cysts, however, the epithelial cells lining the lumen exhibited stronger staining for c-erbB-2 protein, but no staining for EGFR. All 16 benign ovarian tumours and the 2 borderline malignant ovarian tumours were positive for c-erbB-2 protein and negative for EGFR. Of the ovarian carcinomas, 13 of the 19 (68.4%) were positive for c-erbB-2 protein and negative for EGFR, while 4 showed positivity for both c-erbB-2 protein and EGFR. Two cases were negative for both proteins. Expression of both c-erbB-2 protein and EGFR was found in endometrioid carcinoma with squamous differentiation and in clinically advanced poorly differentiated serous carcinomas. Expression of c-erbB-2 protein appears to be increased and that of EGFR is reduced in the early stage of epithelial ovarian oncogenesis. The expression of EGFR with c-erbB-2 protein in ovarian carcinoma is related both to histological differentiation and/or advanced clinical stage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606911
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  • 4
    Electronic Resource
    Electronic Resource
    Immunohistochemical localization of adult T-cell leukaemia-derived factor, a human thioredoxin homologue, in human fetal tissues (1991)
    Springer
    Virchows Archiv 419 (1991), S. 317-326 
    Details
    ISSN: 1432-2307
    Keywords: Adult T-cell leukaemia ; Derived factor ; Immunohistochemistry ; Thioredoxin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An immunohistochemical study of the expression of adult T-cell leukaemia-derived factor (ADF), a human thioredoxin homologue, was performed using a rabbit antibody against the C-terminal peptides of ADF. Tissues were obtained from human fetuses between 9 and 23 weeks of gestation. It was revealed that ADF was widely distributed in different organs and tissues during the fetal period. The ADF antibody reacted selectively with medullary cells of the thymus, lung epithelium, the epithelium of the digestive tract, hepatocytes, bladder epithelium, peripheral nerve cells, hair follicles, sebaceous glands, osteoblasts and the proximal tubules of the kidney. It also reacted with cells destined to differentiate into ciliated cells in the fallopian tube and efferent ductules of the testis, interstitial cells in the ovary, Leydig cells of the testis, and dendritic cells in the spleen and lymph nodes. This is the first report on the thioredoxin system in human cells during the early fetal period. The selectivity of ADF staining in fetal tissues suggests that, during early fetal life, ADF expression correlates well with the cellular function of certain tissues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606523
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  • 5
    Electronic Resource
    Electronic Resource
    Immunohistochemical analysis of p53 protein over-expression in endometrial carcinomas: Inverse correlation with sex steroid receptor status (1993)
    Springer
    Virchows Archiv 423 (1993), S. 265-271 
    Details
    ISSN: 1432-2307
    Keywords: Endometrial carcinoma ; p53 ; Immunohis tochemistry ; Oestrogen receptor ; Progesterone receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mutations of the tumour suppressor p53 gene have been reported in a variety of human malignant tumours, and are frequently associated with over-expression of p53 protein. To examine the significance of p53 gene alteration in endometrial carcinomas, we studied the immunohistochemical reactivity with a monoclonal antibody against p53 (PAb 1801) in 30 endometrial carcinomas as well as in 64 normal endometria. The presence or absence of correlation of p53 over-expression with the clinicopathological features and with the immunohistochemical expression of sex steroid receptors (oestrogen receptors; ER, progesterone receptors; PR) was also analysed. Expression of p53 was found in none of 64 normal endometria, but was identified in 5 of the 30 (16.7%) endometrial carcinomas. All 5 of the p53-positive tumours developed in women more than 3 years post-menopause, whereas the carcinomas in 5 pre-menopausal women and 3 women less than 3 years post-menopause were p53-negative. None of the 5 p53-positive carcinomas was associated with adjacent endometrial hyperplasia. Two of the 5 p53-positive tumours showed non-endometrioid histology: serous papillary and clear cell carcinomas. In contrast, 6 carcinomas accompanied by adjacent hyperplasia were p53-negative. In addition, ER and/or PR expression was found in none of the 5 p53-positive tumours, but was present in 21 of the 25 p53-negative tumours (p〈0.01). These clinicopathological features of p53-positive carcinomas and the inverse correlation of p53 immunoreactivity with sex steroid receptor status suggest that p53 over-expression is frequent in a specific category of endometrial carcinoma, presumably oestrogen-unrelated tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606889
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  • 6
    Electronic Resource
    Electronic Resource
    Smooth muscle differentiation at endometrio-myometrial junction (1989)
    Springer
    Virchows Archiv 414 (1989), S. 105-112 
    Details
    ISSN: 1432-2307
    Keywords: Emdometrio-myometrial junction ; Myofibroblast ; Smooth muscle ; Differentiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To determine whether myometrial smooth muscle is newly produced at the endometrio-myometrial junction (EMJ) of the adult uterus, we examined the ultrastructure of mesenchymal components at this site during the menstrual cycle and during early pregnancy. Cells having some features of smooth muscle were found among the usual endometrial stromal cells in every specimen examined. In the follicular phase of the menstrual cycle, such cells resembled myofibroblasts, but in the luteal phase and during early pregnancy, they had more distinct cytoplasmic filaments with dense bodies and dense plaques, and other fairly well developed characteristics of smooth muscle. The identification of smooth muscle-like cells at the EMJ in the adult uterus and the finding that their morphology changes into cells having many of the characteristics of smooth muscle cells during the luteal phase and early pregnancy, suggests that smooth muscle differentiation possibly occurs from multi-potential mesenchymal cells in the endometrial stroma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00718589
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  • 7
    Electronic Resource
    Electronic Resource
    Immunohistochemical localization of oestrogen receptors and progesterone receptors in the human ovary throughout the menstrual cycle (1990)
    Springer
    Virchows Archiv 417 (1990), S. 369-375 
    Details
    ISSN: 1432-2307
    Keywords: Oestrogen receptor ; Progesterone receptor ; Human ovary ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Immunohistochemistry was used to determine the distribution of oestrogen receptors (ER) and progesterone receptors (PR) in the human ovary during folliculogenesis. Primordial and preantral follicles did not contain ER or PR. The granulosa cells of antral follicles had ER, but negligible PR, before the LH surge. In contrast, at the time of LH surge, these cells of the dominant follicle contained PR, but not ER. On the other hand, granulosa cells of the non-dominant follicles had ER, but not PR. After ovulation, the PR persisted in the luteinized granulosa cells and in the corpus luteum during early pregnancy. The theca interna and surrounding stromal cells were ER-negative and PR-positive throughout the menstrual cycle. Thus, the results show that ER and PR are not expressed simultaneously in the granulosa cells, the thecal cells, or the stromal cells during folliculogenesis. Mechanisms controlling the expression of steroid receptors during the normal menstrual cycle and in early pregnancy are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606025
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  • 8
    Electronic Resource
    Electronic Resource
    Immunohistochemical analysis of oestrogen receptors, progesterone receptors and Ki-67 in leiomyoma and myometrium during the menstrual cycle and pregnancy (1991)
    Springer
    Virchows Archiv 419 (1991), S. 309-315 
    Details
    ISSN: 1432-2307
    Keywords: Oestrogen receptor ; Progesterone receptor ; Ki-67 ; Leiomyoma ; Myometrium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Immunohistochemical distribution of oestrogen receptors (ER), progesterone receptors (PR), and the cell proliferation-associated antigen Ki-67 was investigated in leiomyomas and the myometrium during the menstrual cycle and pregnancy. In the myometrium, ER expression was observed in the proliferative phase, but was suppressed in the secretory phase and during pregnancy. In leiomyomas, ER expression was observed throughout the menstrual cycle, but was suppressed during pregnancy. However, PR was expressed both in the myometrium and leiomyomas throughout the menstrual cycle and pregnancy. In both the myometrium and leiomyomas, a higher number of Ki-67-positive cells was observed during pregnancy than in the secretory phase, and Ki-67 was negative during menopause. The Ki-67-positive cell count in leiomyomas was significantly higher than that in the myometrium throughout the menstrual cycle and pregnancy. Thus both myometrium and leiomyomas have high growth activity under the hormonal milieu of high progesterone levels. The growth potential of leiomyomas is apparently higher than that of myometrium throughout the menstrual cycle and during pregnancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606522
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  • 9
    Electronic Resource
    Electronic Resource
    Expression of c-erbB-2 protein and epidermal growth factor receptor in normal tissues of the female genital tract and in the placenta (1992)
    Springer
    Virchows Archiv 420 (1992), S. 385-393 
    Details
    ISSN: 1432-2307
    Keywords: c-erbB-2 protein ; Epidermal growth factor receptor ; Female genital tract ; Placenta
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The c-erbB-2 (HER-2/neu) protein is a membrane glycoprotein growth factor receptor that has molecular homology with the epidermal growth factor receptor (EGFR). To investigate the relationship between the expression of c-erbB-2 protein and EGFR in the tissues of the human female genital tract and in the placenta, we examined the immunohistochemical reactivity of monoclonal antibodies against both of these proteins. In the müllerian-derived genital tract, epithelial cells of the fallopian tube, endometrium, and endocervix showed reactivity for c-erbB-2 protein, whereas reactivity for EGFR was distributed mainly in the stromal cells throughout the menstrual cycle and during pregnancy. In addition, the staining intensity for EGFR in the endometrial stroma increased with its decidualization. In the exocervical squamous epithelium, basal cells were cerbB-2 protein-negative and EGFR-positive, but the more differentiated squamous cells of the intermediate layer were c-erbB-2 protein-positive and EGFR-negative. In the placental tissues, cytotrophoblasts and syncytiotrophoblasts of the chorionic villi were c-erbB-2 protein-negative and EGFR-positive. In contrast, intermediate trophoblasts in the extravillous space were c-erbB-2 protein-positive and EGFR-negative. Thus, there is an inverse relationship between the expression of c-erbB-2 protein and EGFR in the tissues of the female genital tract and in the placenta. This suggests that there may be a regulatory mechanism(s) for the expression of both proteins that is associated with the differentiation and/or function of cells in the female genital tract and the placenta.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01600509
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  • 10
    Electronic Resource
    Electronic Resource
    Expression of adult T-cell leukaemia-derived factor, a human thioredoxin homologue, in the human ovary throughout the menstrual cycle (1992)
    Springer
    Virchows Archiv 420 (1992), S. 213-217 
    Details
    ISSN: 1432-2307
    Keywords: Adult T-cell leukaemia-derived factor ; Thioredoxin ; Human ovary ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An immunohistochemical study of the expression of adult T-cell leukaemia-derived factor (ADF), a human thioredoxin homologue, was performed in the normal human ovary throughout the menstrual cycle. Primordial follicles were negative for ADF. Both granulosa cells and theca interna cells at the stages of preantral and antral follicles contained ADF. The staining intensity of these cells was very strong in the preovulatory dominant follicle. After ovulation, both granulo-lutein and theca-lutein cells were positive for ADF. During pregnancy, the theca-lutein cells revealed very intense ADF staining. The theca interna cells of the atretic follicles showed ADF staining, while the granulosa cells of such follicles did not. These results suggest that ADF localizes in the ovarian steroidogenic cells which have the binding sites of either luteinizing hormone or folliclestimulating hormone, and that ADF expression is closely associated with the activity of the ovarian steroidogenic cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01600273
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