ISSN:
1573-8221
Keywords:
synthetic polymer
;
colony-forming units
;
bone marrow
;
spleen
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Injection of poly-4-vinylpyridine in the maximal tolerated dose into mice doubles the number of colony-forming units (CFU) in the bone marrow and reduces the number of nucleated cells by 22%. The increase in the CFU pool takes place from the second through the seventh day. The number of bone marrow cells starts to decrease 2 h after injection of the polymer and remains below the initial level for 5 days; after the second day, however, it starts to return gradually to normal, which it reaches by the seventh day. The number of CFU in the spleen increases ninefold, and this is accompanied by the development of marked splenomegaly on account of the increase in the number of cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00807507
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