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  • 1
    ISSN: 0022-2828
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Die Verteilung von ChE im menschlichen Hypothalamus wurde mitKoelles histochemischer Methode untersucht. 2. Die Ganglienzellen der Nuclei paraventriculares und supraoptici zeigen starke ChE-Aktivität. Die Zellen des Nucleus mamillo-infundibularis und des Nucleus tuberis haben starke ChE-Aktivität, doch eine etwas schwächere als die vorher erwähnten. 3. Die kleinen autonomen Zellen der Nuclei ventromedialis und dorsomedialis haben wesentlich schwächere ChE-Aktivität als jene der vorher erwähnten Kerngebiete. 4. ChE-Aktivität findet man im Protoplasma und im Nucleolus der Ganglienzellen. Der Nucleus der Ganglienzellen zeigt keine ChE-Aktivität. 5. Gliazellen haben im allgemeinen verhältnismäßig starke ChE-Aktivität. 6. Die Aktivität von ChE in der Grundsubstanz der einzelnen Teile des Hypothalamus ist verschieden. 7. Die ChE-Aktivität des Corpus mamillare ist so stark wie die des Putamen und des Nucleus caudatus. ChE ist nicht nur in den Ganglienzellen, sondern auch in der Grundsubstanz reichlich vorhanden.
    Abstract: Résumé 1. La distribution du ChE dans l'hypothalamus humain a été étudiée par la méthode histochimique deKoelle. 2. Dans les cellules ganglionnaires des noyaux paraventriculaires et supraoptiques on constate une forte activité de ChE, qui a été observée, si ce n'était qu'à un moindre degré, aussi dans les cellules des noyaux mamillo-infundibulaires et tubériens. 3. L'activité ChE est encore moins marquée dans les petites cellules autonomes des noyaux ventromédians et dorsomédians. 4. Cette activité se trouve dans le protoplasme et le nucléole des cellules ganglionnaires, elle est absente dans le noyau de ces cellules. 5. Les cellules gliales sont de même caractérisées par une activité ChE très marquée. 6. L'activité ChE de la matière de base provenant de l'hypothalamus varie selon la région. 7. L'activité ChE du corps mamillaire est aussi grande que celle des noyaux du putamen et du nucleus caudatus. ChE se présente non seulement dans les cellules ganglionnaires mais aussi en abondance dans la matière de base du corps mamillaire.
    Notes: Summary 1. The distribution of ChE in human hypothalamus was investigated withKoelle's histochemical method. 2. Ganglionic cells of the paraventricular and supraoptic nuclei have strong ChE activity. Cells of the mamillo-infundibular nucleus and of the tuber nucleus have also strong ChE activity, though somewhat weaker than those of the former nuclei. 3. The small autonomic cells of the ventromedian and dorsomedian nuclei have markedly weaker ChE activity than those of the aforementioned nuclei. 4. ChE activity is found in protoplasm and nucleolus of ganglionic cells. However, nucleus of ganglionic cells shows no ChE activity. 5. Glial cells also have usually rather strong ChE activity. 6. The activity of ChE in the ground substance of various portions of hypothalamus is variable. 7. ChE activity of the corpus mamillare is as strong as those of putamen and caudate nucleus. ChE is present not only in ganglionic cells but also abundantly in the ground substance in the corpus mamillare.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 232 (1985), S. 15-19 
    ISSN: 1432-1459
    Keywords: Motor neuron disease ; Liver biopsy ; Abnormal mitochondria ; Intralysosomal copper deposition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In routine liver function tests, 23 of 44 patients with motor neuron disease (MND) had abnormal findings, and there was disturbance of unconjugated bilirubin metabolism in 10 of the 33 patients tested. Liver-biopsy specimens from 10 MND patients were compared by electron microscopic examination with specimens from age-matched controls who had chronic persistent hepatitis. The MND patients had a higher incidence of intramitochondrial inclusions, less abundant mitochondria in a given area of cytoplasm and enlarged mitochondria. Electron-probe X-ray microanalysis of hepatocytic lysosomes found copper in 8 of 13 MND patients, but not in the controls. These findings suggest that the pathogenetic processes in MND may involve not only motor neurons but also hepatic cells.
    Type of Medium: Electronic Resource
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