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  • 1
    Electronic Resource
    Electronic Resource
    Oxidative damage increases with age in a canine model of human brain aging (2002)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 82 (2002), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We assayed levels of lipid peroxidation, protein carbonyl formation, glutamine synthetase (GS) activity and both oxidized and reduced glutathione to study the link between oxidative damage, aging and β-amyloid (Aβ) in the canine brain. The aged canine brain, a model of human brain aging, naturally develops extensive diffuse deposits of human-type Aβ. Aβ was measured in immunostained prefrontal cortex from 19 beagle dogs (4–15 years). Increased malondialdehyde (MDA), which indicates increased lipid peroxidation, was observed in the prefrontal cortex and serum but not in cerebrospinal fluid (CSF). Oxidative damage to proteins (carbonyl formation) also increased in brain. An age-dependent decline in GS activity, an enzyme vulnerable to oxidative damage, and in the level of glutathione (GSH) was observed in the prefrontal cortex. MDA level in serum correlated with MDA accumulation in the prefrontal cortex. Although 11/19 animals exhibited Aβ, the extent of deposition did not correlate with any of the oxidative damage measures, suggesting that each form of neuropathology accumulates in parallel with age. This evidence of widespread oxidative damage and Aβ deposition is further justification for using the canine model for studying human brain aging and neurodegenerative diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2002.00969.x
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  • 2
    Electronic Resource
    Electronic Resource
    DESTRUCTION OF TRICHINELLA SPIRALIS BY LOW-DOSE IRRADIATION OF INFECTED PORK (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food safety 7 (1985), S. 0 
    Details
    ISSN: 1745-4565
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Gamma irradiation of Trichinella spiralis-infected pork with a dose of 15 to 30 krad blocks maturation of ingested larvae in the host gut and prevents production of larval progeny. Experiments with freshly-slaughtered (prerigor) hog carcasses indicate that larvae distributed throughout the skeletal muscles have similar radiosensitivities. Neither the age of the encysted muscle larvae nor vacuum packaging of the meat significantly affected this radiosensitivity. Postirradiation holding of irradiated meat leads to little if any recovery of trichina viability. The data indicate that 30 krad cesium-137 gamma radiation can be delivered to split market-weight hog carcasses with acceptable uniformity, and that under all conditions tested such a dose can provide a substantial margin of safety for human consumption of heavily infected meat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-4565.1985.tb00536.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Comparative morphology and morphometry of alveolar macrophages from six species (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 191 (1991), S. 401-407 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Pulmonary alveolar macrophages (PAM) were collected from normal, healthy mice, rats, dogs, cynomolgus monkeys, chimpanzees, and humans and evaluated for morphologic and morphometric characteristics. The PAM of mice, rats, and dogs were morphologically similar and had statistically similar frequency distributions for size. The cell size distribution or these three species was relatively homogeneous. The PAM of nonhuman primates and humans were morphologically heterogenous with sometimes prominent cytoplasmic vacuolation, irregular cell outlines, and increased numbers of multinucleated cells as compared to the PAM of rodents and dogs. The mean size of human PAM was statistically greater than that for all other species evaluated, including nonhuman primates. These data indicate that significant differences in PAM morphology and size exist among species.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001910407
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    Paper (German National Licenses)
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