ISSN:
1619-7089
Keywords:
Technetium-99m methoxyisobutylisonitrile single photon emission tomography (SPET)
;
Amplitude images
;
Fourier analysis
;
Thallium-201 SPET
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract To determine the role of rest and stress gated technetium-99m methoxyisobutylisonitrile (sestamibi), in the detection of coronary artery disease, routine Fourier analysis of these images was performed with the best septal left anterior oblique (LAO) position of 20 patients (17 men, 3 women; aged 40–75 years) who also underwent rest or redistribution/stress single photon emission tomography (SPET) (99mTc-sestamibi and Thallium-201), gated blood pool imaging and coronary angiogram. There were 6 patients with single-vessel disease, 6 with two-vessel disease, 4 with three-vessel disease, 2 with coronary spasms, 1 with a patent graft and 1 with anginal episodes but a normal angiogram result. Three normal volunteers (2 women, 1 man; aged 24–26 years) also had rest and stress gated blood pool as well as rest and stress gated 99mTc-sestamibi imaging. Rest and stress 99mTc-ses-tamibi amplitude and phase images depicted regional myocardial wall shortening from the outer layer of the myocardium to the center of the left ventricle as follows a high amplitude halo of maximal negative count rate variaton; a circular thinner halo of negligible amplitude; a central region of maximal positive count rate variation, as the images evolved from end-diastole to end-systole. Similar patterns with regional differences represented abnormal myocardial wall shortening. (99mTc-sestamibi and 201T1 SPET) images were in agreement in 90% of the patients and 92% of myocardial regions. 201T1 SPET detected 83% of angiographically proven lesions, as compared with 80% for 99mTc-setamibi SPET and 80% for the amplitude images. The amplitude images demonstrated a larger number of other abnormalities not predicted on the angiogram, probably because they were able to detect regions with a potential for flow improvement and transient regional wall shortening abnormalities. Amplitude and phase analyses of gated rest and stress 99mTc-ses-tamibi images are easy to perform and may become an important adjunct to (99mTc-sestamibi SPET) images for a complete evaluation of both regional myocardial perfusion and regional contractile function using a single tracer.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00185853
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