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  • 1
    Electronic Resource
    Electronic Resource
    Cytotoxic effects of neuroleptic drugs (1987)
    Springer
    Psychopharmacology 91 (1987), S. 182-188 
    Details
    ISSN: 1432-2072
    Keywords: Neuroleptic ; Cytotoxicity ; Agranulocytosis ; Tardive dyskinesia ; Phenothiazine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Agranulocytosis and the release of transaminase enzymes from liver cells are known consequences of neuroleptic drug use. These effects are most common with low potency neuroleptic drugs. It has been hypothesized that these effects are due to the direct toxic action of these drugs on blood and liver cells. The purpose of this study is to compare the cytotoxic effects of eight neuroleptic drugs in five different biological test systems. In all of the test systems, thioridazine, chlorpromazine, trifluoperazine, fluphenazine and thiothixene (group one drugs) were the most toxic drugs and molindone was the least toxic. Thioridazine was between 25 and 84 times more toxic than molindone. Loxapine was significantly more toxic than molindone, but less toxic than the group one drugs. Haloperidol was intermediate in toxicity between the group one drugs and loxapine. We conclude that the difference in cytotoxicity of the neuroleptic drugs observed in these experiments accounts in part for the increase in agranulocytosis and hepatotoxicity with thioridazine and chlorpromazine and for the lower incidence of these side effects with less toxic drugs. The possibility that tardive dyskinesia may be due to the cytotoxic effects of neuroleptic drugs is discussed and an experiment to test this hypothesis is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00217059
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Population dynamics in suspension cultures of an animal cell strainThis work was supported by grants C2539 and C3720, National Cancer Institute, by Parke, Davis and Company, Detroit, Michigan and by grant 383 Rackham Funds, The University of Michigan. (1960)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Biochemical and Microbiological Technology and Engineering 2 (1960), S. 253-265 
    Details
    ISSN: 0368-1467
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A composite of several studies by the authors is presented in an attempt to illustrate the use of the suspension culture method to analyze population dynamics of an animal cell strain. On the basis of these studies the nature of the lag and plateau phases is discussed. More extensive discussions of the various studies in relation to the work of others appear elsewhere.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbmte.390020303
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    Paper (German National Licenses)
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