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  • 1
    Electronic Resource
    Electronic Resource
    In Vitro Activation of Rat Brain Protein Kinase C by Polyenoic Very-Long-Chain Fatty Acids (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 62 (1994), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: A variety of fatty acids including the cis-polyunsaturated very-long-chain fatty acids (VLCFA) (〉22 carbon atoms) common in retina, spermatozoa, and brain were examined for their ability to activate protein kinase C (PKC) purified from rat brain. Arachidonic [20:4(n-6)], eicosapentaenoic [20:5(n-3)], and docosahexaenoic [22:6(n- 3)] acids as well as the VLCFA dotriacontatetraenoic [32:4(n-6)] and tetratriacontahexaenoic [34:6(n-3)] were equally capable of activating PKC in vitro with maximal activity being between 25 and 50 μM. The phorbol ester 12-O-tetradecanoylphorbol 13-acetate further enhanced the in vitro activation of PKC when added to the protein kinase assay system with the fatty acids. The fully saturated arachidic acid (20:0) was inactive in both assay systems. The potential significance of the in vitro activation of PKC by the VLCFA is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1994.62041546.x
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  • 2
    Electronic Resource
    Electronic Resource
    Neurotrophic Factors Prevent Ceramide-Induced Apoptosis Downstream of c-Jun N-Terminal Kinase Activation in PC12 Cells (1998)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 71 (1998), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Neurotrophic factors prevent apoptosis of PC12 cells in serum-free medium. The present study determines whether neurotrophic factors can prevent ceramide-induced apoptosis in PC12 cells and investigates the role that c-Jun N-terminal kinase (JNK) activation may play in this system. Ceramide-induced apoptosis was inhibited by nerve growth factor, basic fibroblast growth factor, pituitary adenylyl cyclase-activating peptide, 4-(8-chlorophenylthio)cyclic AMP, and the caspase inhibitor benzyloxycarbonyl-Val-Ala-dl-Asp fluoromethyl ketone (zVAD-FMK). It was surprising that inhibition of extracellular signal-regulated kinase and/or phosphatidylinositol 3-kinase did not markedly block the protective effects exerted by neurotrophic factors against ceramide-induced apoptosis, suggesting that neurotrophic factors can promote survival independently of these signaling pathways. Treatment of PC12 cells with ceramide resulted in a time-dependent increase in JNK activity. However, neither neurotrophic factors nor zVAD-FMK attenuated ceramide-stimulated JNK activation. Further experiments indicated that ceramide-induced apoptosis in PC12 cells requires new protein synthesis, and that nerve growth factor and zVAD-FMK can prevent apoptosis after JNK activity has been detected. These results indicate that ceramide-induced JNK activation is an early event and may be required for the expression of essential components of the apoptotic machinery. It is anticipated that neurotrophic factors inhibit ceramide-induced apoptosis by affecting signaling events downstream of JNK activation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1998.71010161.x
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  • 3
    Electronic Resource
    Electronic Resource
    5-Phosphoribosyl pyrophosphate synthetase from Ehrlich ascites tumor cells (1969)
    s.l. : American Chemical Society
    Biochemistry 8 (1969), S. 1608-1614 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00832a042
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  • 4
    Electronic Resource
    Electronic Resource
    The spindle checkpoint rescues the meiotic segregation of chromosomes whose crossovers are far from the centromere (2007)
    [s.l.] : Nature Publishing Group
    Nature genetics 39 (2007), S. 1273-1277 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Improper meiotic chromosome segregation causes conditions such as Down's syndrome. Recombination promotes proper chromosome segregation in meiosis I; chromosomes without crossovers near the centromere are more likely to segregate to the same spindle pole (nondisjoin). Here we have used budding ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng2120
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  • 5
    Electronic Resource
    Electronic Resource
    Can sequencing shed light on cell cycling? (2001)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 409 (2001), S. 844-846 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Every organism must have cells that can replicate indefinitely. Can the draft human genome sequence tell us how the cell cycle works and how it evolved? We studied two protein families—the cyclins and their partners the cyclin-dependent kinases (Cdks)—and a conserved regulatory circuit, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35057033
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  • 6
    Electronic Resource
    Electronic Resource
    From molecular to modular cell biology (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 402.1999, 6761supp, C47-, (6 S.) 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Although living systems obey the laws of physics and chemistry, the notion of function or purpose differentiates biology from other natural sciences. Organisms exist to reproduce, whereas, outside religious belief, rocks and stars have no purpose. Selection for function has produced the living ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/402c47a0
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  • 7
    Electronic Resource
    Electronic Resource
    Never-in-mitosis in mitosis (1991)
    [s.l.] : Nature Publishing Group
    Nature 353 (1991), S. 701-702 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE cell cycle may be starting to resemble the Soviet Union: the ruling ideology is being pushed aside by a reformist movement from an unexpected quarter. It has been widely believed1'2 that the central event in the induction of mitosis is the activation of a protein kinase composed of p34cdc2 and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/353701a0
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  • 8
    Electronic Resource
    Electronic Resource
    S-phase feedback control in budding yeast independent of tyrosine phosphorylation of P 34 cdc28 (1992)
    [s.l.] : Nature Publishing Group
    Nature 355 (1992), S. 365-368 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We first established that p34CDC2* in budding yeast and p34cjt2 in fission yeast are phosphorylated on homologous tyrosine residues. We prepared extracts from S. cerevisiae cells arrested in S phase with hydroxyurea, precipitated p34, and analysed it by immunoblotting. When ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/355365a0
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  • 9
    Electronic Resource
    Electronic Resource
    Sunburnt fission yeast (1993)
    [s.l.] : Nature Publishing Group
    Nature 363 (1993), S. 302-302 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ON page 368 of this issue1, Walworth and colleagues offer insights into the feedback control that prevents cells with damaged DNA from entering mitosis. They have identified a gene (termed chkl, for check-point) which interacts both with cdc2, a gene that encodes the protein whose activation ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/363302a0
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  • 10
    Electronic Resource
    Electronic Resource
    Creative blocks: cell-cycle checkpoints and feedback controls (1992)
    [s.l.] : Nature Publishing Group
    Nature 359 (1992), S. 599-604 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Before division, cells must ensure that they finish DNA replication, DMA repair and chromosome segregation. They do so by using feedback controls which can detect the failure to complete replication, repair or spindle assembly to arrest the progress of the cell cycle at one of three checkpoints. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/359599a0
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