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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 46 (1986), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: In an effort to gain a more complete understanding of the regulation of myelin basic protein phosphorylation, we have been interested in defining further the mode of regulation of the myelin protein kinase involved in this posttranslational modification. Here we report the partial purification of a protein kinase from rat brain myelin. By gel filtration, it was determined that the molecular weight of this enzyme was in the range of 70–80 × 103 daltons. Furthermore, it was established that at low calcium concentrations, this enzyme was markedly activated by phosphatidylserine in combination with either 4β-phorbol 12-myristate 13-acetate or diolein. The enzyme was not affected by cyclic AMP or by calcium, alone or in combination with calmodulin. On the basis of these findings this enzyme can be identified as a protein kinase C-like enzyme.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 41 (1983), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The regulation of the state of phosphorylation of myelin basic protein has been studied in intact rat optic nerves incubated in vitro. For this purpose the endogenous state of phosphorylation was preserved and the “back-phosphorylation” technique was used to determine the amount of dephosphorylated protein present in extracts of the nerves. Our results indicate that when nerves were incubated in the presence of depolarizing agents, the state of phosphorylation of myelin basic protein was increased. This effect was calcium-dependent and was partly inhibited by chlorpromazine.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 43 (1984), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The influence of action potential conduction in myelinated axons on the state of phosphorylation of myelin basic protein was studied in rat optic nerve incubated in vitro. For this purpose we used a technique that permits continuous recording of the responses of nerves to electrical stimulation together with the “back-phosphorylation” assay. Our results indicate that action potential conduction, but not electrical stimulation, increased the state of phosphorylation of myelin basic protein. The increment in basic protein phosphorylation was related to the number of impulses conducted, up to a maximal change which occurred after 12 × 103 impulses. Also, the effect of action potential conduction was reversible, since the state of myelin basic protein phosphorylation returned to control levels within 5 min of stopping stimulation. These findings raise the interesting possibility that myelin basic protein phosphorylation plays a role in some dynamic function of myelin, perhaps related to ion transport or to the process of recovery of ionic gradients.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Astronomy and Astrophysics 39 (2001), S. 581-631 
    ISSN: 0066-4146
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Physics
    Notes: Abstract The physical basis of chaos in the solar system is now better understood: In all cases investigated so far, chaotic orbits result from overlapping resonances. Perhaps the clearest examples are found in the asteroid belt. Overlapping resonances account for its Kirkwood gaps and were used to predict and find evidence for very narrow gaps in the outer belt. Further afield, about one new "short-period" comet is discovered each year. They are believed to come from the "Kuiper Belt" (at 40 AU or more) via chaotic orbits produced by mean-motion and secular resonances with Neptune. Finally, the planetary system itself is not immune from chaos. In the inner solar system, overlapping secular resonances have been identified as the possible source of chaos. For example, Mercury, in 1012 years, may suffer a close encounter with Venus or plunge into the Sun. In the outer solar system, three-body resonances have been identified as a source of chaos, but on an even longer time scale of 109 times the age of the solar system. On the human time scale, the planets do follow their orbits in a stately procession, and we can predict their trajectories for hundreds of thousands of years. That is because the mavericks, with shorter instability times, have long since been ejected. The solar system is not stable; it is just old!
    Type of Medium: Electronic Resource
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  • 5
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    Unknown
    New York : Periodicals Archive Online (PAO)
    Current history and Forum. 5:1 (1916:Oct.) 93 
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  • 6
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    Unknown
    New York : Periodicals Archive Online (PAO)
    Current history and Forum. 5:1 (1916:Oct.) 93 
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Springer seminars in immunopathology 8 (1985), S. 29-43 
    ISSN: 1432-2196
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Solar physics 138 (1992), S. 419-422 
    ISSN: 1573-093X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We use Kitt Peak magnetograms to measure polar magnetic fields. The polar mean absolute field increases at the same time as the polar mean field decreases. That is, the polar mean absolute field varies in phase with solar activity, in contrast to the out of phase variation of the mean polar field. We find that the polar fields have a large bipolar component even at solar minimum, with a magnitude equal to that found at low latitudes outside the active latitude bands.
    Type of Medium: Electronic Resource
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