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  • 1
    Electronic Resource
    Electronic Resource
    Predictive value of amniotic fluid cystatin C levels for the early identification of fetuses with obstructive uropathies (2002)
    Oxford, UK : Blackwell Science Ltd
    BJOG 109 (2002), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To compare the diagnostic accuracy of cystatin C with that of creatinine in discriminating renal function in fetuses without ultrasononographic evidence of renal malformations from those with obstructive uropathies.Design Prospective, observational cohort study.Setting Prenatal morphologic and functional evaluation of fetal obstructive uropathies throughout pregnancy.Population A total of 96 healthy pregnant women at different stages of pregnancy, without any pregnancy-related maternal disease. Eighty-one pregnant women without clinical and ultrasonographic evidence of any fetal anomaly, confirmed at birth, were defined as controls; 15 pregnant women with various fetal obstructive uropathies, evidenced by repeated ultrasound examinations and confirmed at birth, were defined as cases.Methods Creatinine was measured by a kinetic Jaffe picric acid method and cystatin C by a nephelometric immunoassay. Variables were analysed by applying conventional statistical tests; the non-parametric receiver operating curves (ROC) analysis was used to evaluate the diagnostic efficiencies of the biochemical markers.Main outcome measures Incidence of confirmed, diagnosed, neonatal obstructive uropathy by measuring baseline levels of cystatin C and creatinine in amniotic fluid.Results Baseline levels of cystatin C in amniotic fluid were significantly higher (P= 0.0015) among cases than in controls with comparable gestational age; no significant difference was found for creatinine levels (P= n.s.). The maximum diagnostic accuracy of serum cystatin C in discriminating controls from fetal uropathies was 96%, while that of creatinine was 62%.Conclusion Cystatin C may be considered a sensitive biochemical marker for the early identification of fetuses with obstructive uropathies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.2002.01430.x
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  • 2
    Electronic Resource
    Electronic Resource
    Evaluation of antibiotic-induced nephrotoxicity in preterm neonates by determining urinary α1-microglobulin (1996)
    Springer
    Pediatric nephrology 10 (1996), S. 645-647 
    Details
    ISSN: 1432-198X
    Keywords: Key words:α1-Microglobulin ; Nephrotoxicity ; Neonates ; Antibiotics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. α1-Microglobulin (α1-m, protein HC), a relatively low molecular weight protein of about 31,000 daltons, was measured in urine of three groups of 34 preterm neonates: group A consisted of 9 healthy preterm neonates; groups B (n = 13) and C (n = 12) consisted of preterm neonates with suspected or confirmed bacterial infections. Immediately after birth, all group B neonates were treated with ampicillin and aztreonam in combination, and all group C neonates were treated with oxacillin and amikacin in combination. To optimize amikacin administration, computerized individually tailored doses were administered. Urine samples were obtained from a short collection in sterile bags on the 1st, 4th, and 7th day after delivery in all infants. Urinary α1-m concentrations were measured by a turbidimetric method (latex agglutination photometric immunoassay) and results were expressed as a ratio to urinary creatinine. In group A, urinary α1-m concentrations were stable after birth. In group C, α1-m excretion increased immediately within the 1st day of treatment, and over the 1st week of life urinary α1-m levels were significantly higher than in group A (P = 0.033). These data support the conclusion that amikacin administration was the most important factor inducing renal tubular dysfunction in the neonates of group C.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670050181
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    Paper (German National Licenses)
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