ISSN:
1432-1041
Keywords:
liver cirrhosis
;
coumarin metabolism
;
mono-oxygenase activity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary 1. The activities of the two kinetic components (high and low affinity) of the microsomal 0-deethylation of 7-ethoxycoumarin have been measured in liver from patients with alcoholic cirrhosis and in normals. 2. The activity (expressed as pmol 7-OH coumarin formed/mg microsomal protein/min) of both components of the enzyme was significantly lower in alcoholic cirrhosis (high affinity=3.27±1.18, low affinity 60.9±11.6) than in normals (high affinity 9.43±2.37, low affinity 111.3±9.2). 3. These results are further evidence that there is a broad impairment of hepatic microsomal mono-oxygenase activity in alcoholic cirrhosis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00546710
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