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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Trauma und Berufskrankheit 2 (2000), S. S268 
    ISSN: 1436-6274
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1440
    Keywords: Key words Calcium ; Liver ; Tumor necrosis factor ; Hemorrhage ; Lipid peroxidation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Tumor necrosis factor-α (TNF-α) is a key mediator of shock-induced cellular and humoral inflammatory cascades. The present study investigated the role of TNF-α in oxidative membrane injury and altered hepatocyte Ca2+ regulation, both of which are critical steps in cellular dysfunction during ischemia/reperfusion events. Hemorrhagic shock was induced by bleeding male Sprague-Dawley rats (200–250 g, n=6/group) to a mean arterial blood pressure of 40 mmHg for 60 min. Rats were resuscitated with 60% of shed blood and twice the shed blood volume as Ringers’ lactate. At the end of hemorrhage and 60 min after resuscitation, hepatocytes were isolated by liver collagenase perfusion. Hepatocyte Ca2+ uptake (Ca2+ up) and Ca2+ membrane flux (Ca2+ flux) were determined by 45Ca2+ incubation techniques. Hepatocyte reduced/oxidized glutathione and lipid peroxidation were determined fluorometrically. Both hemorrhage and hemorrhage/resuscitation significantly increased hepatocyte Ca2+ up and Ca2+ flux. The monoclonal chimeric mouse γ1 TNF-α antibody (TN3γ1.19.12; 20 mg/kg b.w.) given with resuscitation significantly decreased hepatocyte Ca2+ up and Ca2+ flux and prevented hepatocyte lipid peroxidation. These findings suggest that oxidative membrane injury could be the result of TNF-α modulation of hepatocellular Ca2+ regulation during hemorrhage/resuscitation.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Trauma und Berufskrankheit 2 (2000), S. S241 
    ISSN: 1436-6274
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Trauma und Berufskrankheit 2 (2000), S. S258 
    ISSN: 1436-6274
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Trauma und Berufskrankheit 2 (2000), S. S257 
    ISSN: 1436-6274
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Trauma und Berufskrankheit 2 (2000), S. S249 
    ISSN: 1436-6274
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1436-2813
    Keywords: Key Words: right hemidiaphramatic rupture ; diagnosis ; computed tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Archives of orthopaedic and trauma surgery 91 (1978), S. 129-135 
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zwischen Osteosyntheseschraube und -platee treten Reibemomente auf, die zu einer ausgeprägten Oberflächenbeschädigung mit der Gefahr der Reibkorrosion und zu einer Verringerung der Schraubenzugkraft führen. Beschichteten wir die Schraubenköpfe mit PTFE- oder Graphit-Gleitlack, so ließ sich die Reibung signifikant verringern und die Schraubenzugkraft um 40% erhöhen. Rasterelektronenmikroskopisch konnte dabei eine Verminderung der Oberflächenschäden nachgewiesen werden. Zur Überprüfung der Gewebeverträglichkeit wurden Gleitlacke und Lackextrakte mit fötalem Kälber-serum und mit Dimethylsulfoxid Fibroblastenkulturen zugesetzt. Als Maß für die Toxizität diente die DNS-Syntheserate, die autoradiographisch ermittelt wurde. Diese wurde durch Zusatz von Gleitlack und Kälber-serum-Lackextrakt nicht herabgesetzt. Auch bei in-vivo-Versuchen an Ratten, in die gleitlackbeschichtete Teflonplättchen implantiert wurden, konnte eine gute lokale und systemische Gewebeverträglichkeit festgestellt werden.
    Notes: Summary The screws and plates used in operative treatment of fractures cause moments of friction between the bone screw head and the bone plate hole during the tightening of the screws. This results in hidden damage to the grinding metal surfaces, with the danger of erosion corrosion and in a reduction in the screw force. By covering the screw heads with the lubricating sprays PTFE or graphite friction was significantly reduced, the screw force increased by 40% and extensive damage to the surfaces avoided. Lubricating sprays or their extracts, in fetal calf serum or in dimethylsulfoxide, were added to fibroblast cultures. Toxicity was manifest as changes in the synthesis of DNA, as measured by autoradiography. Sprays or spray extracts in fetal calf serum did not inhibit cell proliferation. In vivo experiments in rats reflected the in vitro results, there being no evidence that toxic substances were released from the sprays by physiological solvents: There was a lack of histopathological changes in the inner organs and a local encapsulation of implants which was essentially like that in a teflon control group.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Operative Orthopädie und Traumatologie 12 (2000), S. 209-219 
    ISSN: 1439-0981
    Keywords: Schlüsselwörter Skapulafraktur ; Dorsaler Zugang ; Zwei-Portal-Zugang ; Glenoidfraktur ; Key Words Fracture of scapula ; Glenoid fracture ; Posterior approach to scapula ; Two-portal approach
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Objectives Wide approach to the posterior aspect of the scapula for internal fixation of unstable fractures of neck of scapula and glenoid. Indications Unstable scapular neck and glenoid fractures of Ideberg types II, III, IV and V. Contraindications Minimally displaced and stable fractures of scapular neck. Immediate intervention in polytrauma patients with respiratory insufficiency. Uncontrolled coagulopathies. Surgical Technique Curvilinear skin incision from acromion to inferior scapular angle. The first portal is made at the cranial border of the infraspinatus muscle avoiding injury to the suprascapular nerve. This allows access to the superior scapular neck and posterior glenoid. The second portal is made between infraspinatus and teres minor to reach the inferior parts of the scapular neck and glenoid. The 2 portals are connected by undermining the infraspinatus, thus exposing the entire posterior surface of the scapular neck and of glenoid fossa. The scapular fractures can then be reduced and stabilized. Results The two-portal approach was used in 19 patients, 6 of whom had an unstable scapular neck fracture. The remaining 13 patients had a glenoid fracture of Ideberg types II to V. The fixation was stable in all patients allowing an early functional treatment. The reduction of glenoid fractures was anatomical in 6, and in 6 a gap of 〈 2 mm remained. No intra- or postoperative complications occurred. All patients were followed up for an average of 26 months (6 to 39 months). The following Constant point count was recorded: pain 12.8/15, activities of daily living 16.6/20 and strength 21.5/25. The overall point score was 79.9/100. One patient had developed a minor arthritis of the acromioclavicular joint.
    Notes: Zusammenfassung Operationsziel Zugang zur dorsalen Skapula (Skapulahals und Schulterpfanne) zur Osteosynthese. Indikationen Instabile Skapulahals- und Schulterpfannenfrakturen des Typs Ideberg, II, III, IV und V. Kontraindikationen Minimal dislozierte und stabile Frakturen des Skapulahalses. Frühphase nach Polytrauma mit respiratorischer Insuffizienz. Persistierende Blutgerinnungsstörung. Operationstechnik Bogenförmige Hautinzision vom Akromion entlang der Spina scapulae bis zum Angulus inferior scapulae. Erstes Portal oberhalb des Musculus infraspinatus unter Rücksichtnahme auf den Nervus suprascapularis; damit können die oberen Anteile des Skapulahalses und der hinteren Gelenkpfanne dargestellt werden. Zweites Portal zwischen Musculus infraspinatus und Musculus teres minor, um die unteren Anteile des Skapulahalses und der Gelenkpfanne zu erreichen. Die beiden Portale werden durch Unterfahren des Musculus infraspinatus verbunden, sodass die gesamte Rückfläche des Skapulahalses und der Gelenkpfanne eingesehen werden kann. Ergebnisse 19 Patienten – 6 mit instabilen Skapulahalsfrakturen, vier davon mit zusätzlichen Klavikulafrakturen – und 13 mit Schulterpfannenfrakturen vom Typ Ideberg II bis V wurden behandelt. Bei allen wurde eine stabile Osteosynthese erreicht. Bei den Schulterpfannenfrakturen gelang die Reposition sechsmal anatomisch. Sechsmal verblieb ein interfragmentärer Spalt von weniger als 2 mm. Keine intra- oder postoperativen Komplikationen. Alle Patienten wurden nach durchschnittlich 26 Monaten (sechs bis 39 Monate) nachuntersucht. Nach dem Constant-Score [1] fanden sich folgende Punktzahlen: für den Schmerz 12,8 von 15, für die Alltagsfunktionen 16,6 von 20 und für die Kraft 21,5 von 25. Die Gesamtpunktzahl lag bei 79,9 von 100 möglichen bei einem Wert für die gesunde Gegenseite von durchschnittlich 94,3 Punkten. Ein Patient wies nach zwei Jahren eine geringgradige AC-Gelenk-Arthrose auf.
    Type of Medium: Electronic Resource
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